MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Peters RR et al. | Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. | 1999 | Life Sci. | pmid:10403502 |
Raikhlin-Eisenkraft B and Bentur Y | Ecbalium elaterium (squirting cucumber)--remedy or poison? | 2000 | J. Toxicol. Clin. Toxicol. | pmid:10866331 |
Oberlies NH et al. | Bioactive constituents of the roots of Licania intrapetiolaris. | 2001 | J. Nat. Prod. | pmid:11325234 |
Litaudon M et al. | Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill. | 2003 | Nat. Prod. Res. | pmid:12822899 |
Toker G et al. | Callus formation and cucurbitacin B accumulation in Ecballium elaterium callus cultures. | 2003 | Fitoterapia | pmid:14630164 |
Wu PL et al. | Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis. | 2004 | Chem. Pharm. Bull. | pmid:14993759 |
Clericuzio M et al. | Cucurbitane triterpenoids from Leucopaxillus gentianeus. | 2004 | J. Nat. Prod. | pmid:15568769 |
Agil A et al. | Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium. | 1999 | Planta Med. | pmid:15609462 |
Chen JC et al. | Cucurbitacins and cucurbitane glycosides: structures and biological activities. | 2005 | Nat Prod Rep | pmid:16010347 |