Cucurbitacin B

Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.

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Introduction

To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cucurbitacin B?

Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cucurbitacin B

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Cucurbitacin B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cucurbitacin B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cucurbitacin B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cucurbitacin B?

There are no associated biomedical information in the current reference collection.

What genes are associated with Cucurbitacin B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cucurbitacin B?

Xenograft Model

Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Cucurbitacin B

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Authors Title Published Journal PubMed Link
Guo J et al. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. 2014 PLoS ONE pmid:24505404
Kongtun S et al. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. 2009 Planta Med. pmid:19288406
Agil A et al. Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium. 1999 Planta Med. pmid:15609462
Banzouzi JT et al. Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity. 2008 Planta Med. pmid:18704883
Zhu JS et al. Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells. 2012 Pharmacology pmid:22699368
Zhang M et al. Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. 2010 Pancreas pmid:20182390
Niu Y et al. PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells. 2016 Oxid Med Cell Longev pmid:28042385
Gupta P and Srivastava SK Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. 2014 Oncotarget pmid:24729020
Cai F et al. Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells. 2016 Oncol. Rep. pmid:27350399
Litaudon M et al. Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill. 2003 Nat. Prod. Res. pmid:12822899