| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Total
2
Cucurbitacin B
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cucurbitacin B?
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
PubChem Associated disorders and diseases
What pathways are associated with Cucurbitacin B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cucurbitacin B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cucurbitacin B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cucurbitacin B?
There are no associated biomedical information in the current reference collection.
What genes are associated with Cucurbitacin B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cucurbitacin B?
Xenograft Model
Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Cucurbitacin B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jung ME and Lui RM | Studies toward the total syntheses of cucurbitacins B and D. | 2010 | J. Org. Chem. | pmid:20873743 |
| Chen W et al. | Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. | 2010 | Int. J. Oncol. | pmid:20664943 |
| Chan KT et al. | Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. | 2010 | Cancer Lett. | pmid:19700240 |
| Iwanski GB et al. | Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. | 2010 | Br. J. Pharmacol. | pmid:20590594 |
| Zhang M et al. | Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling. | 2010 | Pancreas | pmid:20182390 |
| Wang W et al. | Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability. | 2010 | Drug Deliv | pmid:20148709 |
| Duangmano S et al. | Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle. | 2010 | Int J Mol Sci | pmid:21614210 |
| Chen C et al. | Cucurbitane-type triterpenoids from the stems of Cucumis melo. | 2009 | J. Nat. Prod. | pmid:19348465 |
| Kongtun S et al. | Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. | 2009 | Planta Med. | pmid:19288406 |
| Thoennissen NH et al. | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. | 2009 | Cancer Res. | pmid:19605406 |
| Abou-Khalil R et al. | Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands. | 2009 | J. Photochem. Photobiol. B, Biol. | pmid:19380237 |
| Zhang M et al. | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. | 2009 | Cancer Chemother. Pharmacol. | pmid:18521604 |
| Molavi O et al. | Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. | 2008 | Int J Pharm | pmid:17681440 |
| Liu T et al. | Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. | 2008 | Eur Arch Otorhinolaryngol | pmid:18309509 |
| Haritunians T et al. | Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. | 2008 | Leuk. Res. | pmid:18405967 |
| Wakimoto N et al. | Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. | 2008 | Cancer Sci. | pmid:18627377 |
| Liu T et al. | [Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells]. | 2008 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:18652313 |
| Banzouzi JT et al. | Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity. | 2008 | Planta Med. | pmid:18704883 |
| Yin D et al. | Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. | 2008 | Int. J. Cancer | pmid:18561312 |
| Liu T et al. | Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. | 2008 | Eur. J. Pharmacol. | pmid:18442812 |