MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Liu T et al. | [Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells]. | 2008 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:18652313 |
Banzouzi JT et al. | Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity. | 2008 | Planta Med. | pmid:18704883 |
Yin D et al. | Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. | 2008 | Int. J. Cancer | pmid:18561312 |
Chen C et al. | Cucurbitane-type triterpenoids from the stems of Cucumis melo. | 2009 | J. Nat. Prod. | pmid:19348465 |
Kongtun S et al. | Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. | 2009 | Planta Med. | pmid:19288406 |
Thoennissen NH et al. | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. | 2009 | Cancer Res. | pmid:19605406 |
Abou-Khalil R et al. | Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands. | 2009 | J. Photochem. Photobiol. B, Biol. | pmid:19380237 |
Zhang M et al. | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. | 2009 | Cancer Chemother. Pharmacol. | pmid:18521604 |
Wang W et al. | Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability. | 2010 | Drug Deliv | pmid:20148709 |
Duangmano S et al. | Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle. | 2010 | Int J Mol Sci | pmid:21614210 |