Cucurbitacin D

Cucurbitacin d is a lipid of Sterol Lipids (ST) class. The involved functions are known as Transcription, Genetic. Cucurbitacin d often locates in Membrane.

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Introduction

To understand associated biological information of Cucurbitacin D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cucurbitacin D?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Cucurbitacin D

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cucurbitacin D?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cucurbitacin D?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cucurbitacin D?

There are no associated biomedical information in the current reference collection.

What genes are associated with Cucurbitacin D?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Cucurbitacin D?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cucurbitacin D

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Authors Title Published Journal PubMed Link
Ku JM et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. 2015 Mol. Cell. Biochem. pmid:26169986
Jacquot C et al. Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6). 2014 Anticancer Res. pmid:25202060
Abbas S et al. The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver. 2013 Toxicol. Lett. pmid:23194827
Ishii T et al. Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells. 2013 Tumour Biol. pmid:23150173
Spear SA et al. Natural compounds as potential treatments of NF2-deficient schwannoma and meningioma: cucurbitacin D and goyazensolide. 2013 Otol. Neurotol. pmid:23928514
Song Y et al. Cucurbitacin D is a new inflammasome activator in macrophages. 2013 Int. Immunopharmacol. pmid:24140411
Ding N et al. Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia. 2011 Cancer pmid:21656752
Jung ME and Lui RM Studies toward the total syntheses of cucurbitacins B and D. 2010 J. Org. Chem. pmid:20873743
Sahranavard S et al. New cucurbitane-type triterpenoids from Bryonia aspera. 2010 Planta Med. pmid:20108178
Takahashi N et al. Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro. 2009 Int. Immunopharmacol. pmid:19185617
Abou-Khalil R et al. Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands. 2009 J. Photochem. Photobiol. B, Biol. pmid:19380237
Banzouzi JT et al. Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity. 2008 Planta Med. pmid:18704883
Greige-Gerges H et al. Effect of cucurbitacins on bilirubin-albumin binding in human plasma. 2007 Life Sci. pmid:17097690
Clericuzio M et al. Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus. 2006 J. Nat. Prod. pmid:17190463
Seger C et al. A new cucurbitacin D related 16,23-epoxy derivative and its isomerization products. 2004 Org. Lett. pmid:14961641
Park CS et al. Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages. 2004 J. Pharmacol. Exp. Ther. pmid:14752064
Rodriguez N et al. Cytotoxic cucurbitacin constituents from Sloanea zuliaensis. 2003 J. Nat. Prod. pmid:14640532
Ito A et al. Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. 2002 Phytochemistry pmid:12169311
Oh H et al. Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. 2002 Planta Med. pmid:12357397
Dinan L et al. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. 1997 Biochem. J. pmid:9581538