| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang WD et al. | ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY. | 2017 | Afr J Tradit Complement Altern Med | pmid:28573224 |
| Chawech R et al. | Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad. | 2015 | Molecules | pmid:26437392 |
| Arumuggam N et al. | A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer. | 2015 | Phytother Res | pmid:25787773 |
| Kuo TC et al. | The effect of red light and far-red light conditions on secondary metabolism in agarwood. | 2015 | BMC Plant Biol. | pmid:26067652 |
| Guo J et al. | The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained release carriers: in situ-forming implants. | 2015 | AAPS PharmSciTech | pmid:25609378 |
| Davidovich-Rikanati R et al. | Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.). | 2015 | Yeast | pmid:25308777 |
| Theis N et al. | Attracting mutualists and antagonists: plant trait variation explains the distribution of specialist floral herbivores and pollinators on crops and wild gourds. | 2014 | Am. J. Bot. | pmid:25156980 |
| Chen CH et al. | Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha. | 2014 | BMC Genomics | pmid:25005802 |
| Muchtaridi M et al. | Potential activity of fevicordin-A from Phaleria macrocarpa (Scheff) Boerl. seeds as estrogen receptor antagonist based on cytotoxicity and molecular modelling studies. | 2014 | Int J Mol Sci | pmid:24776765 |
| Wang Y et al. | Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. | 2014 | PLoS ONE | pmid:24587010 |
| Bai M et al. | Development and validation of an LC-ESI-MS/MS method for the quantitation of hemslecin A in rhesus monkey plasma and its application in pharmacokinetics. | 2014 | Biomed. Chromatogr. | pmid:24132644 |
| Lang KL et al. | Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line. | 2014 | J. Mol. Graph. Model. | pmid:24378396 |
| Ahmed MS and Halaweish FT | Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma. | 2014 | J Enzyme Inhib Med Chem | pmid:23368732 |
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| Lang KL et al. | Chemical modification produces species-specific changes in cucurbitacin antifeedant effect. | 2013 | J. Agric. Food Chem. | pmid:23646892 |
| Zhang YT et al. | Formation of cofilin-actin rods following cucurbitacin-B-induced actin aggregation depends on Slingshot homolog 1-mediated cofilin hyperactivation. | 2013 | J. Cell. Biochem. | pmid:23695982 |
| Guo RH et al. | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23385212 |
| He J et al. | Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages. | 2013 | Int. Immunopharmacol. | pmid:23541744 |
| Gabrielsen M et al. | Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target. | 2013 | Cell Commun. Signal | pmid:23945128 |
| Ayyad SE et al. | In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma. | 2012 | Environ. Toxicol. Pharmacol. | pmid:22245841 |
| Pan L et al. | Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis. | 2012 | J. Nat. Prod. | pmid:22239601 |
| Henrich CJ et al. | Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis. | 2012 | Apoptosis | pmid:21928090 |
| Chen X et al. | Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. | 2012 | Anticancer Drugs | pmid:22561419 |
| Ren S et al. | Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation. | 2012 | Cancer Chemother. Pharmacol. | pmid:22814677 |
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| Bartalis J and Halaweish FT | In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. | 2011 | Bioorg. Med. Chem. | pmid:21459003 |
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| Boykin C et al. | Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. | 2011 | Br. J. Cancer | pmid:21304528 |
| Pedersen AB and Godfrey LD | Evaluation of cucurbitacin-based gustatory stimulant to facilitate cucumber beetle (Coleoptera: Chrysomelidae) management with foliar insecticides in melons. | 2011 | J. Econ. Entomol. | pmid:21882695 |
| Lee DH et al. | Cucurbitacin: ancient compound shedding new light on cancer treatment. | 2010 | ScientificWorldJournal | pmid:20209387 |
| Patel SK et al. | Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation. | 2010 | Biomaterials | pmid:19796808 |
| Patel SK et al. | Molecular dynamics study of the encapsulation capability of a PCL-PEO based block copolymer for hydrophobic drugs with different spatial distributions of hydrogen bond donors and acceptors. | 2010 | Biomaterials | pmid:19962756 |
| Ramalhete C et al. | New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells. | 2009 | Bioorg. Med. Chem. | pmid:19733087 |
| Patel SK et al. | Roles of nonpolar and polar intermolecular interactions in the improvement of the drug loading capacity of PEO-b-PCL with increasing PCL content for two hydrophobic Cucurbitacin drugs. | 2009 | Biomacromolecules | pmid:19655789 |
| Abou-Khalil R et al. | Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands. | 2009 | J. Photochem. Photobiol. B, Biol. | pmid:19380237 |
| Maloney KN et al. | Actin-aggregating cucurbitacins from Physocarpus capitatus. | 2008 | J. Nat. Prod. | pmid:18959442 |
| Chen J et al. | Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. | 2008 | Phytochemistry | pmid:18045630 |
| Beurel E and Jope RS | Differential regulation of STAT family members by glycogen synthase kinase-3. | 2008 | J. Biol. Chem. | pmid:18550525 |
| Molavi O et al. | Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. | 2008 | Int J Pharm | pmid:17681440 |
| Chaves DC et al. | Cucurbitacins from Cayaponia racemosa: isolation and total assignment of 1H and 13C NMR spectra. | 2007 | Magn Reson Chem | pmid:17372957 |
| Bhandari P et al. | Cucurbitacins from Bacopa monnieri. | 2007 | Phytochemistry | pmid:17442350 |
| Zheng CH et al. | A new cucurbitacin from Bolbostemma paniculatum Franguent. | 2007 | J Asian Nat Prod Res | pmid:17454317 |
| Zhang JF et al. | [Comparison of preparing two polylactide nanoparticles loaded lipophilic anti-cancer herb drug by nanoprecipitation method]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17455462 |
| Tannin-Spitz T et al. | Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17942079 |
| Escandell JM et al. | Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17065367 |
| Allen JG et al. | The bioactivity-guided isolation and structural identification of toxic cucurbitacin steroidal glucosides from stemodia kingii. | 2006 Jul-Aug | Phytochem Anal | pmid:16910038 |
| Zou JM et al. | A new cucurbitacin from Picria fel-terrae. | 2006 | J Asian Nat Prod Res | pmid:16864449 |
| Kim IH et al. | Iridoid glycosides and cucurbitacin glycoside from Neopicrorhiza scrophulariiflora. | 2006 | Phytochemistry | pmid:17070880 |
| Nayab D et al. | Cucurbitacin glucosides from Citrullus colocynthis. | 2006 | Nat. Prod. Res. | pmid:16644537 |
| Sun J et al. | Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. | 2005 | Oncogene | pmid:15735720 |
| Seger C et al. | 1H and 13C NMR signal assignment of cucurbitacin derivatives from Citrullus colocynthis (L.) Schrader and Ecballium elaterium L. (Cucurbitaceae). | 2005 | Magn Reson Chem | pmid:15772995 |
| Zhang JF et al. | [The preparation of the polylacticacid nanoparticles of cucurbitacin and their drug loading]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15810448 |
| Yang X et al. | [Relationships of Aulacophora beetles feeding behavior with cucurbitacin types in host crops]. | 2005 | Ying Yong Sheng Tai Xue Bao | pmid:16252877 |
| Bartalis J and Halaweish FT | Relationship between cucurbitacins reversed-phase high-performance liquid chromatography hydrophobicity index and basal cytotoxicity on HepG2 cells. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15734155 |
| Recio MC et al. | Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots. | 2004 | Planta Med. | pmid:15124085 |
| Kawahara N et al. | Two new cucurbitacin glucosides, opercurins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata). | 2004 | Chem. Pharm. Bull. | pmid:15305007 |
| Siegfried BD et al. | Monitoring western corn rootworm (Coleoptera: Chrysomelidae) susceptibility to carbaryl and cucurbitacin baits in the areawide management pilot program. | 2004 | J. Econ. Entomol. | pmid:15568365 |
| Gillespie JJ et al. | Convergent evolution of cucurbitacin feeding in spatially isolated rootworm taxa (Coleoptera: Chrysomelidae; Galerucinae, Luperini). | 2003 | Mol. Phylogenet. Evol. | pmid:12967617 |
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| Shaw JT and Hummel HE | A monitoring trap for Diabrotica virgifera virgifera and D. barberi adults lured with a poisoned cucurbitacin bait. | 2003 | Commun. Agric. Appl. Biol. Sci. | pmid:15149093 |
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Cucurbitacin S
Cucurbitacin s is a lipid of Sterol Lipids (ST) class. The involved functions are known as establishment and maintenance of localization and nitric oxide biosynthetic process.
Cross Reference
Introduction
To understand associated biological information of Cucurbitacin S, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cucurbitacin S?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Cucurbitacin S
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cucurbitacin S?
There are no associated biomedical information in the current reference collection.
What functions are associated with Cucurbitacin S?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cucurbitacin S?
There are no associated biomedical information in the current reference collection.
What genes are associated with Cucurbitacin S?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Cucurbitacin S?
There are no associated biomedical information in the current reference collection.