Cucurbitacin S

Cucurbitacin s is a lipid of Sterol Lipids (ST) class. The involved functions are known as establishment and maintenance of localization and nitric oxide biosynthetic process.

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Introduction

To understand associated biological information of Cucurbitacin S, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cucurbitacin S?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Cucurbitacin S

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cucurbitacin S?

There are no associated biomedical information in the current reference collection.

What functions are associated with Cucurbitacin S?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Cucurbitacin S?

There are no associated biomedical information in the current reference collection.

What genes are associated with Cucurbitacin S?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Cucurbitacin S?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cucurbitacin S

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Authors Title Published Journal PubMed Link
Yang PQ et al. Cucurbitacin contents in Hemsleya dolichocarpa. 1991 Am. J. Chin. Med. pmid:1897490
Chen X et al. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. 2012 Anticancer Drugs pmid:22561419
Henrich CJ et al. Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis. 2012 Apoptosis pmid:21928090
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Witkowski A et al. Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes. 1984 Biochem. Pharmacol. pmid:6546879
Witkowski A and Konopa J Binding of the cytotoxic and antitumor triterpenes, cucurbitacins, to glucocorticoid receptors of HeLa cells. 1981 Biochim. Biophys. Acta pmid:6894552
Patel SK et al. Roles of nonpolar and polar intermolecular interactions in the improvement of the drug loading capacity of PEO-b-PCL with increasing PCL content for two hydrophobic Cucurbitacin drugs. 2009 Biomacromolecules pmid:19655789
Patel SK et al. Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation. 2010 Biomaterials pmid:19796808
Patel SK et al. Molecular dynamics study of the encapsulation capability of a PCL-PEO based block copolymer for hydrophobic drugs with different spatial distributions of hydrogen bond donors and acceptors. 2010 Biomaterials pmid:19962756
Bai M et al. Development and validation of an LC-ESI-MS/MS method for the quantitation of hemslecin A in rhesus monkey plasma and its application in pharmacokinetics. 2014 Biomed. Chromatogr. pmid:24132644
Bartalis J and Halaweish FT In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. 2011 Bioorg. Med. Chem. pmid:21459003
Ramalhete C et al. New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells. 2009 Bioorg. Med. Chem. pmid:19733087
Guo RH et al. Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. 2013 Bioorg. Med. Chem. Lett. pmid:23385212
Chen CH et al. Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha. 2014 BMC Genomics pmid:25005802
Kuo TC et al. The effect of red light and far-red light conditions on secondary metabolism in agarwood. 2015 BMC Plant Biol. pmid:26067652
Boykin C et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. 2011 Br. J. Cancer pmid:21304528
Ren S et al. Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation. 2012 Cancer Chemother. Pharmacol. pmid:22814677
Jayaprakasam B et al. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. 2003 Cancer Lett. pmid:12445672
GALLILY R et al. Further studies on the antitumor effect of cucurbitacins. 1962 Cancer Res. pmid:13946249
Gabrielsen M et al. Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target. 2013 Cell Commun. Signal pmid:23945128