(2e,4e)-deca-2,4-dienal

(2e,4e)-deca-2,4-dienal is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 362 references associated with (2e,4e)-deca-2,4-dienal in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (2e,4e)-deca-2,4-dienal

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2e,4e)-deca-2,4-dienal

MeSH term MeSH ID Detail
Congenital Abnormalities D000013 11 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Lung Neoplasms D008175 171 associated lipids
Total 5

NCBI Entrez Crosslinks

All references with (2e,4e)-deca-2,4-dienal

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Authors Title Published Journal PubMed Link
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Cadet J et al. Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal. 1999 IARC Sci. Publ. pmid:10626212
Carvalho VM et al. Novel 1,N(6)-etheno-2'-deoxyadenosine adducts from lipid peroxidation products. 2000 Chem. Res. Toxicol. pmid:10813657
Loureiro AP et al. trans,trans-2,4-decadienal-induced 1,N(2)-etheno-2'-deoxyguanosine adduct formation. 2000 Chem. Res. Toxicol. pmid:10898592
Spiteller P et al. Aldehydic lipid peroxidation products derived from linoleic acid. 2001 Biochim. Biophys. Acta pmid:11325611
Girona J et al. 2,4-Decadienal downregulates TNF-alpha gene expression in THP-1 human macrophages. 2001 Atherosclerosis pmid:11500179
Lin J et al. Quantification of key odorants formed by autoxidation of arachidonic acid using isotope dilution assay. 2001 Lipids pmid:11521974
Pohnert G Phospholipase A2 activity triggers the wound-activated chemical defense in the diatom Thalassiosira rotula. 2002 Plant Physiol. pmid:12011342
Caldwell GS et al. Inhibition of embryonic development and fertilization in broadcast spawning marine invertebrates by water soluble diatom extracts and the diatom toxin 2-trans,4-trans decadienal. 2002 Aquat. Toxicol. pmid:12204592
Czerny M and Schieberle P Important aroma compounds in freshly ground wholemeal and white wheat flour-identification and quantitative changes during sourdough fermentation. 2002 J. Agric. Food Chem. pmid:12405784
Bezman Y et al. Differential effects of tomato (Lycopersicon esculentum mill) matrix on the volatility of important aroma compounds. 2003 J. Agric. Food Chem. pmid:12537448
Niknahad H et al. Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals. 2003 Chem. Biol. Interact. pmid:12604195
Akakabe Y et al. 2,4-Decadienals are produced via (R)-11-HPITE from arachidonic acid in marine green alga Ulva conglobata. 2003 Bioorg. Med. Chem. pmid:12901905
Cabré A et al. Cytotoxic effects of the lipid peroxidation product 2,4-decadienal in vascular smooth muscle cells. 2003 Atherosclerosis pmid:12921975
Romano G et al. A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos. 2003 J. Exp. Biol. pmid:12939379
Caldwell GS et al. The use of a brine shrimp (Artemia salina) bioassay to assess the toxicity of diatom extracts and short chain aldehydes. 2003 Toxicon pmid:14559082
Loureiro AP et al. Structural characterization of diastereoisomeric ethano adducts derived from the reaction of 2'-deoxyguanosine with trans,trans-2,4-decadienal. 2004 Chem. Res. Toxicol. pmid:15144221
Hansen E et al. Isolation and characterisation of a cytotoxic polyunsaturated aldehyde from the marine phytoplankter Phaeocystis pouchetii (Hariot) Lagerheim. 2004 Toxicology pmid:15147794
pmid:15201434
Wu SC and Yen GC Effects of cooking oil fumes on the genotoxicity and oxidative stress in human lung carcinoma (A-549) cells. 2004 Toxicol In Vitro pmid:15251174
Shirokova E et al. Identification of specific ligands for orphan olfactory receptors. G protein-dependent agonism and antagonism of odorants. 2005 J. Biol. Chem. pmid:15598656
Caldwell GS et al. Exposure to 2,4-decadienal negatively impacts upon marine invertebrate larval fitness. 2005 Mar. Environ. Res. pmid:15603766
Chang LW et al. Trans, trans-2,4-decadienal, a product found in cooking oil fumes, induces cell proliferation and cytokine production due to reactive oxygen species in human bronchial epithelial cells. 2005 Toxicol. Sci. pmid:16014734
Vardi A et al. A stress surveillance system based on calcium and nitric oxide in marine diatoms. 2006 PLoS Biol. pmid:16475869
Yuan Q et al. Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation. 2007 Chem. Res. Toxicol. pmid:17226935
Hung HS et al. Association of cooking oil fumes exposure with lung cancer: involvement of inhibitor of apoptosis proteins in cell survival and proliferation in vitro. 2007 Mutat. Res. pmid:17229588
Zamora R et al. Strecker degradation of phenylalanine initiated by 2,4-decadienal or methyl 13-oxooctadeca-9,11-dienoate in model systems. 2007 J. Agric. Food Chem. pmid:17300152
Chen W et al. Identification of volatile degradants in formulations containing sesame oil using SPME/GC/MS. 2007 J Pharm Biomed Anal pmid:17412547
pmid:17488119
Sigolo CA et al. Covalent modification of cytochrome c exposed to trans,trans-2,4-decadienal. 2007 Chem. Res. Toxicol. pmid:17658762
Ribalet F et al. Growth inhibition of cultured marine phytoplankton by toxic algal-derived polyunsaturated aldehydes. 2007 Aquat. Toxicol. pmid:17942163
Ribalet F et al. Differential effect of three polyunsaturated aldehydes on marine bacterial isolates. 2008 Aquat. Toxicol. pmid:18093670
Chang YC and Lin P Trans, trans-2,4-decadienal induced cell proliferation via p27 pathway in human bronchial epithelial cells. 2008 Toxicol. Appl. Pharmacol. pmid:18187174
Gallardo E et al. Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. 2008 J. Agric. Food Chem. pmid:18386901
Buttino I et al. Aldehyde-encapsulating liposomes impair marine grazer survivorship. 2008 J. Exp. Biol. pmid:18424676
Morita M and Tokita M Hydroxy radical, hexanal, and decadienal generation by autocatalysts in autoxidation of linoleate alone and with eleostearate. 2008 Lipids pmid:18493810
Vardi A et al. A diatom gene regulating nitric-oxide signaling and susceptibility to diatom-derived aldehydes. 2008 Curr. Biol. pmid:18538570
Lin PP et al. Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells. 2008 Biochem. Biophys. Res. Commun. pmid:18796293
Endo S et al. Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. 2009 Chem. Biol. Interact. pmid:18845131
Liu ZX and Liu ZX [Chemical constituents from the seed of Chimonanthus praecox extracted by supercritical carbon dioxide]. 2008 Zhong Yao Cai pmid:18973012
Zamora R et al. Conversion of 3-aminopropionamide and 3-alkylaminopropionamides into acrylamide in model systems. 2009 Mol Nutr Food Res pmid:19746374
Wang CK et al. Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes. 2010 Eur. Respir. J. pmid:19797125
Harispe L et al. Biochemical analysis of a recombinant glutathione transferase from the cestode Echinococcus granulosus. 2010 Acta Trop. pmid:20034460
pmid:20063203
Zhu X et al. Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal. 2010 Chem. Res. Toxicol. pmid:20070074
pmid:20143344
pmid:20371854
pmid:20936405
Chan PC NTP toxicity studies of toxicity studies of 2,4-decadienal (CAS No. 25152-84-5) administered by gavage to F344/N Rats and B6C3F1 mice. 2011 Toxic Rep Ser pmid:21445102
pmid:21570935