| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tinea | D014005 | 5 associated lipids |
| Mycoses | D009181 | 18 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Total
4
Ergosterol
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ergosterol?
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ergosterol
PubChem Associated disorders and diseases
What pathways are associated with Ergosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ergosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ergosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ergosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ergosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ergosterol?
Knock-out
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ergosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shingu K et al. | Ergostane glycosides from Petunia hybrida. | 1994 | Phytochemistry | pmid:7765367 |
| Yamano S et al. | Metabolic engineering for production of beta-carotene and lycopene in Saccharomyces cerevisiae. | 1994 | Biosci. Biotechnol. Biochem. | pmid:7765036 |
| Kirsch DR and DiDomenico BJ | Mechanism-based screening for the discovery of novel antifungals. | 1994 | Biotechnology | pmid:7749303 |
| Nikawa H et al. | The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin. | 1994 | Arch. Oral Biol. | pmid:7741664 |
| Klebe G et al. | Different approaches toward an automatic structural alignment of drug molecules: applications to sterol mimics, thrombin and thermolysin inhibitors. | 1994 | J. Comput. Aided Mol. Des. | pmid:7738608 |
| Hammond SM and Kliger BN | Mode of action of the polyene antibiotic candicidin: binding factors in the wall of Candida albicans. | 1976 | Antimicrob. Agents Chemother. | pmid:773298 |
| Bĕhalová B et al. | Regulation of sterol biosynthesis in Saccharomyces cerevisiae. | 1994 | Folia Microbiol. (Praha) | pmid:7729765 |
| Bailey RB et al. | Enzymatic analysis of C27 sterol-accumulating yeast strains. | 1976 | J. Bacteriol. | pmid:770446 |
| Kerwin JL et al. | Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. | 1995 | Microbiology (Reading, Engl.) | pmid:7704271 |
| Kaya K et al. | Astasin, a novel cytotoxic carbohydrate-conjugated ergosterol from the colorless euglenoid, Astasia longa. | 1995 | Biochim. Biophys. Acta | pmid:7696335 |
| Cohen FS and Niles WD | Reconstituting channels into planar membranes: a conceptual framework and methods for fusing vesicles to planar bilayer phospholipid membranes. | 1993 | Meth. Enzymol. | pmid:7688845 |
| De Luca C et al. | Ergosterol oxidation may be considered a signal for fungal growth and aflatoxin production in Aspergillus parasiticus. | 1995 May-Jun | Food Addit Contam | pmid:7664941 |
| Devi PU et al. | In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. | 1995 | Cancer Lett. | pmid:7656229 |
| Axelsson BO et al. | Determination of ergosterol in organic dust by gas chromatography-mass spectrometry. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:7655624 |
| Lamb DC et al. | Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients. | 1995 | FEBS Lett. | pmid:7628631 |
| Vannier-Santos MA et al. | Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania. | 1995 Jul-Aug | J. Eukaryot. Microbiol. | pmid:7620457 |
| Fanelli C et al. | Effect of different inhibitors of sterol biosynthesis on both fungal growth and aflatoxin production. | 1995 | Nat. Toxins | pmid:7613735 |
| Venkateswarlu K et al. | Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. | 1995 | FEMS Microbiol. Lett. | pmid:7557345 |
| Tuller G and Daum G | Import of sterols into mitochondria of the yeast Saccharomyces cerevisiae. | 1995 | FEBS Lett. | pmid:7556637 |
| Urbina JA et al. | Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7548131 |