| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tinea | D014005 | 5 associated lipids |
| Mycoses | D009181 | 18 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Total
4
Ergosterol
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ergosterol?
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ergosterol
PubChem Associated disorders and diseases
What pathways are associated with Ergosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ergosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ergosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ergosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ergosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ergosterol?
Knock-out
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ergosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ye M et al. | (24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells. | 2013 | Nat. Prod. Res. | pmid:22889249 |
| Fan J et al. | Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. | 2013 | New Phytol. | pmid:23442154 |
| Dadakova K et al. | Elucidation of signaling molecules involved in ergosterol perception in tobacco. | 2013 | Plant Physiol. Biochem. | pmid:24095918 |
| Elschner T et al. | Syntheses and detailed structure characterization of dextran carbonates. | 2013 | Carbohydr Polym | pmid:23465922 |
| Chen YL et al. | Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. | 2013 | PLoS ONE | pmid:23472097 |
| Tanaka AR et al. | p38MAPK and Rho-dependent kinase are involved in anoikis induced by anicequol or 25-hydroxycholesterol in DLD-1 colon cancer cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23266613 |
| Zavrel M et al. | Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. | 2013 | Eukaryotic Cell | pmid:23475705 |
| Hirz M et al. | A novel cholesterol-producing Pichia pastoris strain is an ideal host for functional expression of human Na,K-ATPase α3β1 isoform. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23955473 |
| ValentÃn L et al. | Mycoremediation of wood and soil from an old sawmill area contaminated for decades. | 2013 | J. Hazard. Mater. | pmid:23832059 |
| Brilhante RS et al. | Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii. | 2013 | Antimicrob. Agents Chemother. | pmid:23459491 |
| Wu SH et al. | Two new steroids from an endophytic fungus Phomopsis sp. | 2013 | Chem. Biodivers. | pmid:23847072 |
| Robalo JR et al. | Behavior of fluorescent cholesterol analogues dehydroergosterol and cholestatrienol in lipid bilayers: a molecular dynamics study. | 2013 | J Phys Chem B | pmid:23597397 |
| Šimová Z et al. | The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. | 2013 | Yeast | pmid:23606207 |
| Eddouzi J et al. | Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. | 2013 | Antimicrob. Agents Chemother. | pmid:23629718 |
| Chiu YF et al. | In vivo probing of the temperature responses of intracellular biomolecules in yeast cells by label-free Raman microspectroscopy. | 2013 | Chembiochem | pmid:23630156 |
| Österlund T et al. | Mapping condition-dependent regulation of metabolism in yeast through genome-scale modeling. | 2013 | BMC Syst Biol | pmid:23631471 |
| Pinto E et al. | Antifungal activity of Ferulago capillaris essential oil against Candida, Cryptococcus, Aspergillus and dermatophyte species. | 2013 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:23619574 |
| Lafleur MD et al. | Potentiation of azole antifungals by 2-adamantanamine. | 2013 | Antimicrob. Agents Chemother. | pmid:23689724 |
| Campos-Bermudez VA et al. | Transcriptional and metabolic changes associated to the infection by Fusarium verticillioides in maize inbreds with contrasting ear rot resistance. | 2013 | PLoS ONE | pmid:23637860 |
| Iwaki A et al. | Vanillin inhibits translation and induces messenger ribonucleoprotein (mRNP) granule formation in saccharomyces cerevisiae: application and validation of high-content, image-based profiling. | 2013 | PLoS ONE | pmid:23637899 |
| Tesnière C et al. | Impact of nutrient imbalance on wine alcoholic fermentations: nitrogen excess enhances yeast cell death in lipid-limited must. | 2013 | PLoS ONE | pmid:23658613 |
| Georgiev AG et al. | Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport. | 2013 | Traffic | pmid:23668914 |
| Cvelbar D et al. | Steroid toxicity and detoxification in ascomycetous fungi. | 2013 | Chem. Biol. Interact. | pmid:23257178 |
| Jiang C et al. | Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. | 2013 | J. Antimicrob. Chemother. | pmid:23221625 |
| Pacheco A et al. | C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. | 2013 | PLoS ONE | pmid:24040213 |
| South PF et al. | H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23382196 |
| Tung NT et al. | Inhibitory effect on NO production of triterpenes from the fruiting bodies of Ganoderma lucidum. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23357630 |
| Wu SJ et al. | Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. | 2013 | Am. J. Chin. Med. | pmid:23336512 |
| Davey ML et al. | Amplicon-pyrosequencing-based detection of compositional shifts in bryophyte-associated fungal communities along an elevation gradient. | 2013 | Mol. Ecol. | pmid:23190367 |
| Sun N et al. | Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants. | 2013 | Antimicrob. Agents Chemother. | pmid:23147730 |
| Bitencourt TA et al. | Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. | 2013 | BMC Complement Altern Med | pmid:24044691 |
| Liu X et al. | Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum. | 2013 | Mol. Plant Pathol. | pmid:22947191 |
| Henderson CM et al. | Fermentation temperature modulates phosphatidylethanolamine and phosphatidylinositol levels in the cell membrane of Saccharomyces cerevisiae. | 2013 | Appl. Environ. Microbiol. | pmid:23811519 |
| Cabral ME et al. | Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification. | 2013 | Rev Iberoam Micol | pmid:23069981 |
| Clemmensen KE et al. | Roots and associated fungi drive long-term carbon sequestration in boreal forest. | 2013 | Science | pmid:23539604 |
| Irshad M et al. | Composition of Cassia fistula oil and its antifungal activity by disrupting ergosterol biosynthesis. | 2013 | Nat Prod Commun | pmid:23513744 |
| Jost DI et al. | Microbial biomass in faeces of dairy cows affected by a nitrogen deficient diet. | 2013 | Arch Anim Nutr | pmid:23521691 |
| Yasuda K et al. | UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23548573 |
| Razzaghi-Abyaneh M et al. | Effects of Heracleum persicum ethyl acetate extract on the growth, hyphal ultrastructure and aflatoxin biosynthesis in Aspergillus parasiticus. | 2013 | Mycotoxin Res | pmid:23780853 |
| Shinde RB et al. | An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans. | 2013 | J. Gen. Appl. Microbiol. | pmid:23759870 |
| Rodrigues C et al. | Effect of forced aeration on citric acid production by Aspergillus sp. mutants in SSF. | 2013 | World J. Microbiol. Biotechnol. | pmid:23760557 |
| MikhaÄlova EV et al. | [The effects of RH 421 on the activity of amphotericin B in cell and model membranes]. | 2013 | Tsitologiia | pmid:23718076 |
| Fangkrathok N et al. | Bioactive ergostanoids and a new polyhydroxyoctane from Lentinus polychrous mycelia and their inhibitory effects on E2-enhanced cell proliferation of T47D cells. | 2013 | Nat. Prod. Res. | pmid:23163256 |
| Chen Y et al. | Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. | 2013 | J. Med. Microbiol. | pmid:23657528 |
| Thomas E et al. | Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans. | 2013 | Antimicrob. Agents Chemother. | pmid:23979757 |
| Prasad R and Singh A | Lipids of Candida albicans and their role in multidrug resistance. | 2013 | Curr. Genet. | pmid:23974286 |
| Onishi M and Kamimori H | High-throughput and sensitive assay for amphotericin B interaction with lipid membrane on the model membrane systems by surface plasmon resonance. | 2013 | Biol. Pharm. Bull. | pmid:23546296 |
| Vincent BM et al. | Fitness trade-offs restrict the evolution of resistance to amphotericin B. | 2013 | PLoS Biol. | pmid:24204207 |
| Zhang CY et al. | Chemical constituents from an endophytic fungus Chaetomium globosum Z1. | 2013 | Nat Prod Commun | pmid:24273849 |
| Pasricha S et al. | Cell-type-specific transcriptional profiles of the dimorphic pathogen Penicillium marneffei reflect distinct reproductive, morphological, and environmental demands. | 2013 | G3 (Bethesda) | pmid:24062530 |
| Hill JA et al. | Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. | 2013 | PLoS Genet. | pmid:23593013 |
| Morioka S et al. | Effect of sterol composition on the activity of the yeast G-protein-coupled receptor Ste2. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23053114 |
| Su TR et al. | 5alpha,8alpha-epidioxysterols from a Formosan sponge, Axinyssa sp. | 2013 | Nat Prod Commun | pmid:24427934 |
| Clark KE et al. | Ecology- and bioassay-guided drug discovery for treatments of tropical parasitic disease: 5alpha,8alpha-epidioxycholest-6-en-3beta-ol isolated from the mollusk Dolabrifera dolabrifera shows significant activity against Leishmania donovani. | 2013 | Nat Prod Commun | pmid:24427935 |
| Neumann A et al. | The effect of sterols on amphotericin B self-aggregation in a lipid bilayer as revealed by free energy simulations. | 2013 | Biophys. J. | pmid:23561525 |
| Nicotra VE et al. | Withanolides with phytotoxic activity from two species of the genus Salpichroa: S. origanifolia and S. tristis var. lehmannii. | 2013 | J. Nat. Prod. | pmid:24303781 |
| Crabbé A et al. | Spaceflight enhances cell aggregation and random budding in Candida albicans. | 2013 | PLoS ONE | pmid:24324620 |
| Malmierca MG et al. | Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum. | 2013 | Fungal Genet. Biol. | pmid:23454546 |
| Kim N et al. | The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans. | 2013 | Med. Mycol. | pmid:22662760 |
| Semis R et al. | Mechanism of activity and toxicity of Nystatin-Intralipid. | 2013 | Med. Mycol. | pmid:23088298 |
| König M et al. | Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase. | 2013 | Bioorg. Med. Chem. | pmid:23433667 |
| Sørensen JL and Giese H | Influence of carbohydrates on secondary metabolism in Fusarium avenaceum. | 2013 | Toxins (Basel) | pmid:24064720 |
| Cicogna F et al. | Interaction of azole compounds with DOPC and DOPC/ergosterol bilayers by spin probe EPR spectroscopy: implications for antifungal activity. | 2013 | J Phys Chem B | pmid:24032998 |
| Xiao L et al. | Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China. | 2013 | World J. Microbiol. Biotechnol. | pmid:22910972 |
| Wu QP et al. | Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance. | 2012 | PLoS ONE | pmid:22952996 |
| Krumpe K et al. | Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. | 2012 | Mol. Biol. Cell | pmid:22918956 |
| Lee IS et al. | Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus. | 2012 | J. Antibiot. | pmid:22922478 |
| Flowers SA et al. | Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. | 2012 | Eukaryotic Cell | pmid:22923048 |
| Kim J et al. | A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs. | 2012 | Fungal Genet. Biol. | pmid:22975303 |
| Poklepovich TJ et al. | The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. | 2012 | Steroids | pmid:22982564 |
| Dupont S et al. | Ergosterol biosynthesis: a fungal pathway for life on land? | 2012 | Evolution | pmid:22946816 |
| Tagliari L et al. | Membrane microdomain components of Histoplasma capsulatum yeast forms, and their role in alveolar macrophage infectivity. | 2012 | Biochim. Biophys. Acta | pmid:22197503 |
| Toh Choon RL et al. | Ergosterol from the soilborne fungus Ganoderma boninense. | 2012 | J. Basic Microbiol. | pmid:22143962 |
| Ostroumova OS et al. | Probing amphotericin B single channel activity by membrane dipole modifiers. | 2012 | PLoS ONE | pmid:22276169 |
| Haldar S et al. | Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. | 2012 | Biophys. J. | pmid:22500756 |
| Maxfield FR and Wüstner D | Analysis of cholesterol trafficking with fluorescent probes. | 2012 | Methods Cell Biol. | pmid:22325611 |
| Chen C and Tripp CP | A comparison of the behavior of cholesterol, 7-dehydrocholesterol and ergosterol in phospholipid membranes. | 2012 | Biochim. Biophys. Acta | pmid:22465065 |
| Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
| Song MH et al. | A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. | 2012 | Eukaryotic Cell | pmid:22080454 |
| Diezi TA and Kwon G | Amphotericin B/sterol co-loaded PEG-phospholipid micelles: effects of sterols on aggregation state and hemolytic activity of amphotericin B. | 2012 | Pharm. Res. | pmid:22130733 |
| Wang Y et al. | Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. | 2012 | Phytomedicine | pmid:22112725 |
| Wilcock BC et al. | Electronic tuning of site-selectivity. | 2012 | Nat Chem | pmid:23174979 |
| Zhang BY et al. | Chemical constituents of Euphorbia tangutica. | 2012 | Nat. Prod. Res. | pmid:22424102 |
| Jiang JS et al. | [Study on the chemical constituents from Cyathea spinulosa]. | 2012 | Zhong Yao Cai | pmid:23019903 |
| Szponar B et al. | Bacterial and fungal markers in tobacco smoke. | 2012 | Sci. Total Environ. | pmid:23026151 |
| Du YC et al. | Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. | 2012 | Phytomedicine | pmid:22516893 |
| Kořený L et al. | Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22355128 |
| Misra L et al. | 1,4-Dioxane and ergosterol derivatives from Withania somnifera roots. | 2012 | J Asian Nat Prod Res | pmid:22263592 |
| de Lira Mota KS et al. | Antifungal activity of Thymus vulgaris L. essential oil and its constituent phytochemicals against Rhizopus oryzae: interaction with ergosterol. | 2012 | Molecules | pmid:23519243 |
| Vanegas JM et al. | Role of unsaturated lipid and ergosterol in ethanol tolerance of model yeast biomembranes. | 2012 | Biophys. J. | pmid:22325273 |
| Umegawa Y et al. | Head-to-tail interaction between amphotericin B and ergosterol occurs in hydrated phospholipid membrane. | 2012 | Biochemistry | pmid:22129239 |
| Hong KK and Nielsen J | Recovery of phenotypes obtained by adaptive evolution through inverse metabolic engineering. | 2012 | Appl. Environ. Microbiol. | pmid:22904057 |
| Kalaras MD et al. | Generation of potentially bioactive ergosterol-derived products following pulsed ultraviolet light exposure of mushrooms (Agaricus bisporus). | 2012 | Food Chem | pmid:22868105 |
| Miller MB et al. | Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. | 2012 | J. Lipid Res. | pmid:22591742 |
| Hull CM et al. | Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B. | 2012 | Antimicrob. Agents Chemother. | pmid:22615281 |
| Gebre S et al. | Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. | 2012 | Cell Cycle | pmid:22622083 |
| Chiu LD et al. | On the origin of the 1602 cm-1 Raman band of yeasts; contribution of ergosterol. | 2012 | J Biophotonics | pmid:22529062 |
| Ta MT et al. | Accumulation of squalene is associated with the clustering of lipid droplets. | 2012 | FEBS J. | pmid:23013491 |
| Kristan K and Rižner TL | Steroid-transforming enzymes in fungi. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:21946531 |
| Tuckey RC et al. | Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol. | 2012 | Drug Metab. Dispos. | pmid:22106170 |