MeSH term | MeSH ID | Detail |
---|---|---|
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang YM et al. | Ergosterols from the Culture Broth of Marine Streptomyces anandii H41-59. | 2016 | Mar Drugs | pmid:27153073 |
Zhang HY et al. | Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability. | 2016 | Acta Pharmacol. Sin. | pmid:27133301 |
Ferrante T et al. | Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells. | 2016 | Acta Biochim. Pol. | pmid:27031513 |
Song J et al. | The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. | 2016 | MBio | pmid:26908577 |
Bojsen R et al. | A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations. | 2016 | Sci Rep | pmid:26903175 |
Warrilow AG et al. | The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. | 2016 | Antimicrob. Agents Chemother. | pmid:27161631 |
Cordeiro Rde A et al. | Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex. | 2016 | Microbiology (Reading, Engl.) | pmid:26645478 |
Najle SR et al. | Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals. | 2016 | Open Biol | pmid:27383626 |
Konecna A et al. | ERG6 gene deletion modifies Kluyveromyces lactis susceptibility to various growth inhibitors. | 2016 | Yeast | pmid:27668979 |
Cordeiro Rde A et al. | Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones against Coccidioides posadasii. | 2016 | Microb. Pathog. | pmid:27334293 |