Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Mitropoulos KA et al. Lanosterol 14alpha-demethylase. Similarity of the enzyme system from yeast and rat liver. 1976 Steroids pmid:781918
Sjöstrand U et al. Minor and trace sterols from marine invertebrates 29. (22E)-ergosta-5,22,25-trien-3 beta-ol and (22E,24R)-24,26-dimethylcholesta-5,22,25(27)-trien-3 beta-ol. Two new marine sterols from the sponge Pseudaxinella lunacharta. 1981 Steroids pmid:7303039
Naumowicz M et al. Chronopotentiometric studies of phosphatidylcholine bilayers modified by ergosterol. 2011 Sep-Oct Steroids pmid:21641920
Hu JF et al. 26-Nor-25-isopropyl-ergosta-5,7,22E-trien-3beta-ol: a new C(29) sterol from the sponge Agelas sceptrum from Jamaica. 2002 Steroids pmid:12123785
Sato S et al. Identification of 23-demethylacanthasterol in an asteroid, Acanthaster planci and its synthesis. 1980 Steroids pmid:6893371
Bortolotto M et al. Chemical studies of marine inverterbrates. XXIX 4 alpha-Methyl-3 beta 8-beta-dihydroxy-5 alpha-ergost-24(28)-en-23-one, a novel polyoxygenated sterol from the soft coral Litophyton viridis. (Coelenterata, Octocorallia, Alcyonacea). 1977 Steroids pmid:22145
Jeong TM et al. Sterols from a species of Pichia, a n-alkane-utilizing yeast. 1975 Steroids pmid:1154452
Morisaki M et al. Nutritional effect of possible intermediates of phytosterol dealkylation in the silkworm, Bombyx mori. 1974 Steroids pmid:4421556
Gebreyesus T et al. Minor and trace sterols in marine invertebrates 55. The isolation, structure elucidation and synthesis of ergosta-5, 24(28), 25-trien-3 beta-ol. 1985 Steroids pmid:2871644
Brosa C et al. New synthetic strategy for the synthesis of 24-epibrassinolide. 1996 Steroids pmid:8883220
Macías FA et al. Bioactive steroids from Oryza sativa L. 2006 Steroids pmid:16620896
Zhang Y et al. Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger. 2007 Steroids pmid:17628622
Harki E et al. Identification and quantification of Tuber melanosporum Vitt. sterols. 1996 Steroids pmid:8910974
Alcazar-Fuoli L et al. Ergosterol biosynthesis pathway in Aspergillus fumigatus. 2008 Steroids pmid:18191972
Mehdi H et al. Sterols of Acanthamoeba culbertsoni strain A-1. 1988 May-Jun Steroids pmid:3242176
Nes WD et al. Evidence for similarities and differences in the biosynthesis of fungal sterols. 1989 Mar-May Steroids pmid:2678609
Fattorusso E et al. 4,4-Dimethyl-5 alpha-ergosta-8,24(28)-dien-3 beta-ol from the fungus Marasmius oreades. 1992 Steroids pmid:1621266
Wang F and Liu JK Two new steryl esters from the basidiomycete Tricholomopsis rutilans. 2005 Steroids pmid:15631869
Fuska J et al. Microbial transformations of natural antitumor agents. 23. Conversion of withaferin-A to 12 beta- and 15 beta-hydroxy derivatives of withaferin-A. 1982 Steroids pmid:7157453
Stonard RJ et al. A new C26 sterol peroxide from the opisthobranch mollusk Adalaria sp. and the sea pen Virgularia sp. 1980 Steroids pmid:7414658