Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Blume T et al. Two syntheses of FF-MAS. 2003 Org. Lett. pmid:12762665
Lemriss S et al. Screening of nonpolyenic antifungal metabolites produced by clinical isolates of actinomycetes. 2003 Can. J. Microbiol. pmid:14735216
Kaur P et al. Effect of 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide isolated from the roots of Withania somnifera on stress indices in Wistar rats. 2003 J Altern Complement Med pmid:14736361
O'Keeffe J et al. Exposure of the yeast Candida albicans to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B. 2003 J. Pharm. Pharmacol. pmid:14738588
Rossard S et al. Characterization of sterol uptake in leaf tissues of sugar beet. 2003 Planta pmid:12920595
Noda H and Koizumi Y Sterol biosynthesis by symbiotes: cytochrome P450 sterol C-22 desaturase genes from yeastlike symbiotes of rice planthoppers and anobiid beetles. 2003 Insect Biochem. Mol. Biol. pmid:12770582
Onyewu C et al. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. 2003 Antimicrob. Agents Chemother. pmid:12604527
Atshaves BP et al. Sterol carrier protein-2 selectively alters lipid composition and cholesterol dynamics of caveolae/lipid raft vs nonraft domains in L-cell fibroblast plasma membranes. 2003 Biochemistry pmid:14661971
Söderström C et al. Use of an electronic tongue to analyze mold growth in liquid media. 2003 Int. J. Food Microbiol. pmid:12745231
Lübbehüsen TL et al. Morphology and physiology of the dimorphic fungus Mucor circinelloides (syn. M. racemosus) during anaerobic growth. 2003 Mycol. Res. pmid:12747334
Subbiah MT and Abplanalp W Ergosterol (major sterol of baker's and brewer's yeast extracts) inhibits the growth of human breast cancer cells in vitro and the potential role of its oxidation products. 2003 Int J Vitam Nutr Res pmid:12690907
Fornairon-Bonnefond C and Salmon JM Impact of oxygen consumption by yeast lees on the autolysis phenomenon during simulation of wine aging on lees. 2003 J. Agric. Food Chem. pmid:12696941
Bahmed K et al. Relation between cell wall chitin content and susceptibility to amphotericin B in Kluyveromyces, Candida and Schizosaccharomyces species. 2003 Res. Microbiol. pmid:12706511
Gudheti MV et al. Interaction of apolipoprotein A-I with lecithin-cholesterol vesicles in the presence of phospholipase C. 2003 Biochim. Biophys. Acta pmid:14729075
Landry J and Sternglanz R Yeast Fms1 is a FAD-utilizing polyamine oxidase. 2003 Biochem. Biophys. Res. Commun. pmid:12670477
Dahlman L et al. Carbon and nitrogen distribution in the green algal lichens Hypogymnia physodes and Platismatia glauca in relation to nutrient supply. 2003 Planta pmid:12721847
Bracher F [Attack point of ergosterol biosynthesis. Drugs and pharmacology]. 2003 Pharm Unserer Zeit pmid:12677964
Maebashi K et al. Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient. 2003 Microbiol. Immunol. pmid:12680714
Hand RA et al. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. 2003 Eukaryotic Cell pmid:12684380
Liebich J et al. Structural and functional approach to studying pesticide side-effects on specific soil functions. 2003 Environ. Toxicol. Chem. pmid:12685713
Nikolcheva LG et al. Determining diversity of freshwater fungi on decaying leaves: comparison of traditional and molecular approaches. 2003 Appl. Environ. Microbiol. pmid:12732520
Gu JQ et al. Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts. 2003 Chem. Pharm. Bull. pmid:12736452
Urbina JA et al. Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. 2003 Antimicrob. Agents Chemother. pmid:12760897
Avrahami D and Shai Y Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: a plausible mode of action. 2003 Biochemistry pmid:14674771
Krska R et al. Zearalenone in maize: stability testing and matrix characterisation of a certified reference material. 2003 Food Addit Contam pmid:14726278
Yang LY et al. H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis, probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL. 2003 J. Lab. Clin. Med. pmid:12518171
Zhao H et al. Definitive structural identities of Pneumocystis jirovecii sterols. 2003 J. Eukaryot. Microbiol. pmid:14736217
Amborabé BE et al. Specific perception of ergosterol by plant cells. 2003 C. R. Biol. pmid:12876888
Sanglard D et al. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. 2003 Antimicrob. Agents Chemother. pmid:12878497
He X et al. Overexpression of a sterol C-24(28) reductase increases ergosterol production in Saccharomyces cerevisiae. 2003 Biotechnol. Lett. pmid:12882006
Young LY et al. Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. 2003 Antimicrob. Agents Chemother. pmid:12936965
Sardari S et al. Modulatory effect of cAMP on fungal ergosterol level and inhibitory activity of azole drugs. 2003 Can. J. Microbiol. pmid:12897828
Hietala AM et al. Multiplex real-time PCR for monitoring Heterobasidion annosum colonization in Norway spruce clones that differ in disease resistance. 2003 Appl. Environ. Microbiol. pmid:12902224
Higgins VJ et al. Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation. 2003 Appl. Environ. Microbiol. pmid:12902271
Bi Y et al. [Studies on chemical constituents of mycelium of fungus Cephalosporium sp. AL031(II)]. 2003 Zhong Yao Cai pmid:12858768
Murtoniemi T et al. Effect of plasterboard composition on Stachybotrys chartarum growth and biological activity of spores. 2003 Appl. Environ. Microbiol. pmid:12839740
Reeslev M et al. Quantifying mold biomass on gypsum board: comparison of ergosterol and beta-N-acetylhexosaminidase as mold biomass parameters. 2003 Appl. Environ. Microbiol. pmid:12839773
Uma Devi P and Kamath R Radiosensitizing effect of withaferin A combined with hyperthermia on mouse fibrosarcoma and melanoma. 2003 J. Radiat. Res. pmid:12841592
Kuo YC et al. Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. 2003 Br. J. Pharmacol. pmid:14504132
Jayaprakasam B et al. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. 2003 Life Sci. pmid:14575818
Nicotra VE et al. 15,21-Cyclowithanolides from Jaborosa bergii. 2003 J. Nat. Prod. pmid:14640521
Song JL et al. Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans. 2003 Med. Mycol. pmid:14653518
Corente Ch and Knülle W Trophic determinants of hypopus induction in the stored-product mite Lepidoglyphus destructor (Acari: Astigmata). 2003 Exp. Appl. Acarol. pmid:14580061
Malmstrøm J et al. Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor. 2002 J. Nat. Prod. pmid:11908979
Hirotani M et al. Blazeispirols B, C, E and F, des-A-ergostane-type compounds, from the cultured mycelia of the fungus Agaricus blazei. 2002 Phytochemistry pmid:11853754
Baran M and Mazerski J Molecular modelling of amphotericin B-ergosterol primary complex in water. 2002 Biophys. Chem. pmid:11897151
Mareggiani G et al. Response of Tribolium castaneum (Coleoptera, Tenebrionidae) to Salpichroa origanifolia Withanolides. 2002 J. Agric. Food Chem. pmid:11754551
Ferber D Infectious disease. New weapons in the battle of the bugs. 2002 Science pmid:11799221
Matsumoto M et al. Strong antifungal activity of SS750, a new triazole derivative, is based on its selective binding affinity to cytochrome P450 of fungi. 2002 Antimicrob. Agents Chemother. pmid:11796335
Lupetti A et al. Molecular basis of resistance to azole antifungals. 2002 Trends Mol Med pmid:11815273
Shen P et al. A new ergostanol saponin from Dioscorea deltoidea Wall var. orbiculata. 2002 J Asian Nat Prod Res pmid:12118511
Blein JP et al. From elicitins to lipid-transfer proteins: a new insight in cell signalling involved in plant defence mechanisms. 2002 Trends Plant Sci. pmid:12119165
Arthington-Skaggs BA et al. Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Candida isolates. 2002 Antimicrob. Agents Chemother. pmid:12121921
Hu JF et al. 26-Nor-25-isopropyl-ergosta-5,7,22E-trien-3beta-ol: a new C(29) sterol from the sponge Agelas sceptrum from Jamaica. 2002 Steroids pmid:12123785
Hongay C et al. Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. 2002 EMBO J. pmid:12145211
Rebsamen MC et al. 1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase. 2002 Circ. Res. pmid:12114317
John K et al. Rapid transbilayer movement of the fluorescent sterol dehydroergosterol in lipid membranes. 2002 Biophys. J. pmid:12202377
Headley JV et al. Mass spectrometric determination of ergosterol in a prairie natural wetland. 2002 J Chromatogr A pmid:12134812
Maebashi K et al. A novel mechanism of fluconazole resistance associated with fluconazole sequestration in Candida albicans isolates from a myelofibrosis patient. 2002 Microbiol. Immunol. pmid:12139391
Hata K et al. Stimulative effects of (22E,24R)-ergosta-7,22-diene-3beta,5alpha,6beta-triol from fruiting bodies of Tricholoma auratum, on a mouse osteoblastic cell line, MC3T3-E1. 2002 Biol. Pharm. Bull. pmid:12186406
Mogensen JE et al. The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands. 2002 J. Biol. Chem. pmid:11953433
Bhattacharya SK et al. Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia. 2002 Phytomedicine pmid:11995951
Gilbert J et al. Comparison of Canadian Fusarium graminearum isolates for aggressiveness, vegetative compatibility, and production of ergosterol and mycotoxins. 2002 Mycopathologia pmid:12014482
Matsumori N et al. Amphotericin B covalent dimers forming sterol-dependent ion-permeable membrane channels. 2002 J. Am. Chem. Soc. pmid:11960425
Eroglu C et al. Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. 2002 EMBO Rep. pmid:11964379
Hao M et al. Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. 2002 J. Biol. Chem. pmid:11682487
Huang D et al. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. 2002 Mol. Cell. Biol. pmid:12077337
Baranova NA et al. [Micromycetes metabolites--inhibitors of growth and sterol biosynthesis in yeasts]. 2002 Antibiot. Khimioter. pmid:12077938
Kuria KA et al. The antiplasmodial activity of isolates from Ajuga remota. 2002 J. Nat. Prod. pmid:12027771
Barajas-Aceves M et al. Effect of pollutants on the ergosterol content as indicator of fungal biomass. 2002 J. Microbiol. Methods pmid:12031573
Igarashi Y et al. Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213. 2002 J. Antibiot. pmid:12061544
Zhao J et al. Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. 2002 Chem. Pharm. Bull. pmid:12045329
Suárez Y et al. Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription. 2002 Eur. J. Biochem. pmid:11895447
Heimark L et al. Mechanism of azole antifungal activity as determined by liquid chromatographic/mass spectrometric monitoring of ergosterol biosynthesis. 2002 J Mass Spectrom pmid:11921367
Shen YX et al. [Studies on the chemical constituents of Shiraia bambusicola]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12776569
Ponce MA et al. A new look into the reaction between ergosterol and singlet oxygen in vitro. 2002 Photochem. Photobiol. Sci. pmid:12656474
Nishiyama Y [Structure of fungi and the action mechanism of antifungal agents]. 2002 Jpn J Antibiot pmid:12664930
Jelen HH et al. Influence of octanoic acid addition to medium on some volatile compounds and PR-toxin biosynthesis by Penicillium roqueforti. 2002 Lett. Appl. Microbiol. pmid:12081547
Kamińska J et al. The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. 2002 FEMS Yeast Res. pmid:12702319
McDonough V et al. Mutations in erg4 affect the sensitivity of Saccharomyces cerevisiae to medium-chain fatty acids. 2002 Biochim. Biophys. Acta pmid:12020638
Barrero AF et al. Sterols in erg mutants of Phycomyces: metabolic pathways and physiological effects. 2002 Steroids pmid:11958798
Nose H et al. PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. 2002 J. Antibiot. pmid:12546418
Gössnitzer E et al. Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. Part I: synthesis and antifungal activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-substituted 2-imidazolinamines. 2002 Arch. Pharm. (Weinheim) pmid:12596218
Czaczyk K et al. Antifungal activity of Bacillus coagulans against Fusarium sp. 2002 Acta Microbiol. Pol. pmid:12588102
Zhang Y et al. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. 2002 J. Agric. Food Chem. pmid:12475274
Eisenkolb M et al. A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast. 2002 Mol. Biol. Cell pmid:12475962
Hart MM and Reader RJ Does percent root length colonization and soil hyphal length reflect the extent of colonization for all AMF? 2002 Mycorrhiza pmid:12466917
Cinato E et al. A DNA microarray-based approach to elucidate the effects of the immunosuppressant SR31747A on gene expression in Saccharomyces cerevisiae. 2002 Gene Expr. pmid:12450214
Kwon HC et al. Cytotoxic ergosterols from Paecilomyces sp. J300. 2002 Arch. Pharm. Res. pmid:12510837
Paquet MJ et al. The effects of amphotericin B on pure and ergosterol- or cholesterol-containing dipalmitoylphosphatidylcholine bilayers as viewed by 2H NMR. 2002 Chem. Phys. Lipids pmid:12270668
Henry KW et al. ROX1 and ERG regulation in Saccharomyces cerevisiae: implications for antifungal susceptibility. 2002 Eukaryotic Cell pmid:12477804
Mukhopadhyay K et al. Drug susceptibilities of yeast cells are affected by membrane lipid composition. 2002 Antimicrob. Agents Chemother. pmid:12435664
Milhaud J et al. Interactions of the drug amphotericin B with phospholipid membranes containing or not ergosterol: new insight into the role of ergosterol. 2002 Biochim. Biophys. Acta pmid:11779560
Baginski M et al. Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. 2002 Biochim. Biophys. Acta pmid:12488039
Olsson J et al. Detection and quantification of ochratoxin A and deoxynivalenol in barley grains by GC-MS and electronic nose. 2002 Int. J. Food Microbiol. pmid:11845819
Endress E et al. Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering. 2002 Biochemistry pmid:12390036
Huang W et al. Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. 2002 Biophys. J. pmid:12496093
Baran M and Mazerski J Molecular modelling of membrane sterols with the use of the GROMOS 96 force field. 2002 Chem. Phys. Lipids pmid:12426073
Clark AJ My hand was on the doorknob to leave. 2002 Biochem. Biophys. Res. Commun. pmid:11969211
Cybulska B et al. Comparative in vitro studies on liposomal formulations of amphotericin B and its derivative, N-methyl-N-D-fructosyl amphotericin B methyl ester (MFAME). 2002 Acta Biochim. Pol. pmid:12136958