Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ergosterol

Download all related citations
Per page 10 20 50 100 | Total 2233
Authors Title Published Journal PubMed Link
Blume T et al. Two syntheses of FF-MAS. 2003 Org. Lett. pmid:12762665
Gallucci E et al. Magainin 2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol. 2003 Eur. Biophys. J. pmid:12632203
O'Keeffe J et al. Exposure of the yeast Candida albicans to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B. 2003 J. Pharm. Pharmacol. pmid:14738588
Gomès E et al. Nonspecific lipid-transfer protein genes expression in grape (Vitis sp.) cells in response to fungal elicitor treatments. 2003 Mol. Plant Microbe Interact. pmid:12744517
Duport C et al. Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast. 2003 Eur. J. Biochem. pmid:12654006
Rossard S et al. Characterization of sterol uptake in leaf tissues of sugar beet. 2003 Planta pmid:12920595
Onda M et al. Susceptibilities of phospholipid vesicles containing different sterols to amphotericin B-loaded lysophosphatidylcholine micelles. 2003 J. Biochem. pmid:12944378
Wright AD et al. Oxygenated analogues of gorgosterol and ergosterol from the soft coral Capnella lacertiliensis. 2003 J. Nat. Prod. pmid:12608844
Noda H and Koizumi Y Sterol biosynthesis by symbiotes: cytochrome P450 sterol C-22 desaturase genes from yeastlike symbiotes of rice planthoppers and anobiid beetles. 2003 Insect Biochem. Mol. Biol. pmid:12770582
ur-Rahman A et al. Withanolides from Withania coagulans. 2003 Phytochemistry pmid:12770585
Geraghty P and Kavanagh K Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B. 2003 Arch. Microbiol. pmid:12640519
Umebayashi K and Nakano A Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. 2003 J. Cell Biol. pmid:12810702
Ganzera M et al. Quantitative HPLC analysis of withanolides in Withania somnifera. 2003 Fitoterapia pmid:12628397
Onyewu C et al. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. 2003 Antimicrob. Agents Chemother. pmid:12604527
Atshaves BP et al. Sterol carrier protein-2 selectively alters lipid composition and cholesterol dynamics of caveolae/lipid raft vs nonraft domains in L-cell fibroblast plasma membranes. 2003 Biochemistry pmid:14661971
Sebastian A and Larsson L Characterization of the microbial community in indoor environments: a chemical-analytical approach. 2003 Appl. Environ. Microbiol. pmid:12788704
Gössnitzer E et al. Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis. III. Synthesis and antifungal activity of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine salts. 2003 Eur J Pharm Sci pmid:12791418
Klobucníková V et al. Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene. 2003 Biochem. Biophys. Res. Commun. pmid:12963042
Nasir H and Noda H Yeast-like symbiotes as a sterol source in anobiid beetles (Coleoptera, Anobiidae): possible metabolic pathways from fungal sterols to 7-dehydrocholesterol. 2003 Arch. Insect Biochem. Physiol. pmid:12655605
Nicol RW et al. Ginsenosides stimulate the growth of soilborne pathogens of American ginseng. 2003 Phytochemistry pmid:12946424
Gössnitzer E et al. Novel high energy intermediate analogues with a triazasterol structure as potential ergosterol biosynthesis inhibitors IV: antimicrobial activity of mono-, bi-, and tricyclic 8, 13, 15-triazasteroid analogues including the synthesis of novel 4-alkylamino- and 4-alkenylamino-9-hydroxypyrimidoisoquinolines. 2003 Arch. Pharm. (Weinheim) pmid:12953221
Matheson MC et al. Residential characteristics predict changes in Der p 1, Fel d 1 and ergosterol but not fungi over time. 2003 Clin. Exp. Allergy pmid:12956751
Thevissen K et al. DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. 2003 FEMS Microbiol. Lett. pmid:13129623
Söderström C et al. Use of an electronic tongue to analyze mold growth in liquid media. 2003 Int. J. Food Microbiol. pmid:12745231
Lübbehüsen TL et al. Morphology and physiology of the dimorphic fungus Mucor circinelloides (syn. M. racemosus) during anaerobic growth. 2003 Mycol. Res. pmid:12747334
Subbiah MT and Abplanalp W Ergosterol (major sterol of baker's and brewer's yeast extracts) inhibits the growth of human breast cancer cells in vitro and the potential role of its oxidation products. 2003 Int J Vitam Nutr Res pmid:12690907
Fornairon-Bonnefond C and Salmon JM Impact of oxygen consumption by yeast lees on the autolysis phenomenon during simulation of wine aging on lees. 2003 J. Agric. Food Chem. pmid:12696941
Gudheti MV et al. Interaction of apolipoprotein A-I with lecithin-cholesterol vesicles in the presence of phospholipase C. 2003 Biochim. Biophys. Acta pmid:14729075
Bracher F [Attack point of ergosterol biosynthesis. Drugs and pharmacology]. 2003 Pharm Unserer Zeit pmid:12677964
Maebashi K et al. Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient. 2003 Microbiol. Immunol. pmid:12680714
Hand RA et al. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. 2003 Eukaryotic Cell pmid:12684380
Liebich J et al. Structural and functional approach to studying pesticide side-effects on specific soil functions. 2003 Environ. Toxicol. Chem. pmid:12685713
Nikolcheva LG et al. Determining diversity of freshwater fungi on decaying leaves: comparison of traditional and molecular approaches. 2003 Appl. Environ. Microbiol. pmid:12732520
Gu JQ et al. Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts. 2003 Chem. Pharm. Bull. pmid:12736452
Urbina JA et al. Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. 2003 Antimicrob. Agents Chemother. pmid:12760897
Avrahami D and Shai Y Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: a plausible mode of action. 2003 Biochemistry pmid:14674771
Coyle B et al. Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes. 2003 Biometals pmid:12572690
Cherkaoui S et al. Analysis of selected withanolides in plant extract by capillary electrochromatography and microemulsion electrokinetic chromatography. 2003 Electrophoresis pmid:12569525
Krska R et al. Zearalenone in maize: stability testing and matrix characterisation of a certified reference material. 2003 Food Addit Contam pmid:14726278
Rahman A et al. Argyroside from Argyreia nervosa seeds. 2003 Pharmazie pmid:12622256
Rosenfeld E et al. Oxygen consumption by anaerobic Saccharomyces cerevisiae under enological conditions: effect on fermentation kinetics. 2003 Appl. Environ. Microbiol. pmid:12513985
Loeffler J and Stevens DA Antifungal drug resistance. 2003 Clin. Infect. Dis. pmid:12516028
McIntosh AL et al. Fluorescence and multiphoton imaging resolve unique structural forms of sterol in membranes of living cells. 2003 J. Biol. Chem. pmid:12456684
Yang LY et al. H1-A extracted from Cordyceps sinensis suppresses the proliferation of human mesangial cells and promotes apoptosis, probably by inhibiting the tyrosine phosphorylation of Bcl-2 and Bcl-XL. 2003 J. Lab. Clin. Med. pmid:12518171
Zhao H et al. Definitive structural identities of Pneumocystis jirovecii sterols. 2003 J. Eukaryot. Microbiol. pmid:14736217
Amborabé BE et al. Specific perception of ergosterol by plant cells. 2003 C. R. Biol. pmid:12876888
Sanglard D et al. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. 2003 Antimicrob. Agents Chemother. pmid:12878497
He X et al. Overexpression of a sterol C-24(28) reductase increases ergosterol production in Saccharomyces cerevisiae. 2003 Biotechnol. Lett. pmid:12882006
Young LY et al. Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. 2003 Antimicrob. Agents Chemother. pmid:12936965
Veen M et al. Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. 2003 FEMS Yeast Res. pmid:14554200
Murtoniemi T et al. Effect of plasterboard composition on Stachybotrys chartarum growth and biological activity of spores. 2003 Appl. Environ. Microbiol. pmid:12839740
Reeslev M et al. Quantifying mold biomass on gypsum board: comparison of ergosterol and beta-N-acetylhexosaminidase as mold biomass parameters. 2003 Appl. Environ. Microbiol. pmid:12839773
Uma Devi P and Kamath R Radiosensitizing effect of withaferin A combined with hyperthermia on mouse fibrosarcoma and melanoma. 2003 J. Radiat. Res. pmid:12841592
Kaneko E et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. 2003 J. Biol. Chem. pmid:12847102
Kuo YC et al. Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. 2003 Br. J. Pharmacol. pmid:14504132
Nicotra VE et al. 15,21-Cyclowithanolides from Jaborosa bergii. 2003 J. Nat. Prod. pmid:14640521
Song JL et al. Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans. 2003 Med. Mycol. pmid:14653518
Corente Ch and Knülle W Trophic determinants of hypopus induction in the stored-product mite Lepidoglyphus destructor (Acari: Astigmata). 2003 Exp. Appl. Acarol. pmid:14580061
Puglisi E et al. Cholesterol, beta-sitosterol, ergosterol, and coprostanol in agricultural soils. 2003 Mar-Apr J. Environ. Qual. pmid:12708669
Zheng SZ et al. Two new polyporusterones from Polyorus umbellatus. 2004 Nat. Prod. Res. pmid:15248606
Wady L et al. Heterogeneity in microbial exposure in schools in Sweden, Poland and Jordan revealed by analysis of chemical markers. 2004 J Expo Anal Environ Epidemiol pmid:15254476
El-Gamal AA et al. New nardosinanes and 19-oxygenated ergosterols from the soft coral Nephthea armata collected in Taiwan. 2004 J. Nat. Prod. pmid:15387641
Pietri A et al. Occurrence of mycotoxins and ergosterol in maize harvested over 5 years in Northern Italy. 2004 Food Addit Contam pmid:15204549
Munayyer HK et al. Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds. 2004 Antimicrob. Agents Chemother. pmid:15388421
Eshwika A et al. Metal complexes of 1,10-phenanthroline-5,6-dione alter the susceptibility of the yeast Candida albicans to amphotericin B and miconazole. 2004 Biometals pmid:15259362
Markovich S et al. Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. 2004 Antimicrob. Agents Chemother. pmid:15388447
Veras ML et al. Cytotoxic epimeric withaphysalins from leaves of Acnistus arborescens. 2004 Planta Med. pmid:15241891
Fujimoto H et al. Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity. 2004 Chem. Pharm. Bull. pmid:15305003
Li P et al. [Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurized solvent extraction and high performance liquid chromatography]. 2004 Yao Xue Xue Bao pmid:15696933
Larsen T et al. Simplified and rapid method for extraction of ergosterol from natural samples and detection with quantitative and semi-quantitative methods using thin-layer chromatography. 2004 J Chromatogr A pmid:14763758
Maldonado E et al. 18-Acetoxywithanolides from Physalis chenopodifolia1. 2004 Planta Med. pmid:14765295
Krivtsov V et al. Some aspects of interrelations between fungi and other biota in forest soil. 2004 Mycol. Res. pmid:15449599
Silver PM et al. Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. 2004 Eukaryotic Cell pmid:15590814
Wang MM et al. Cholesterol superlattice modulates the activity of cholesterol oxidase in lipid membranes. 2004 Biochemistry pmid:14979712
Mongrand S et al. Lipid rafts in higher plant cells: purification and characterization of Triton X-100-insoluble microdomains from tobacco plasma membrane. 2004 J. Biol. Chem. pmid:15190066
Vanden Bossche H et al. The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. 2004 Antimicrob. Agents Chemother. pmid:15328084
Wang J et al. Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function. 2004 Biochemistry pmid:14744146
Zuckermann MJ et al. Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts. 2004 Meth. Enzymol. pmid:15063652
Coutinho A et al. Cholesterol and ergosterol influence nystatin surface aggregation: relation to pore formation. 2004 Biophys. J. pmid:15315952
Arora A et al. Influence of cholesterol and ergosterol on membrane dynamics: a fluorescence approach. 2004 Biochem. Biophys. Res. Commun. pmid:15147960
Edqvist J et al. Plants express a lipid transfer protein with high similarity to mammalian sterol carrier protein-2. 2004 J. Biol. Chem. pmid:15456765
Radhika P et al. An acetoxygenated analogue of ergosterol from a soft coral of the genus Lobophytum. 2004 Nat. Prod. Res. pmid:15595617
Kanagasabai R et al. Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain. 2004 Lipids pmid:15638241
Valachovic M et al. A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. 2004 Lipids pmid:15638242
Pierson CA et al. Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase. 2004 Med. Mycol. pmid:15552648
Kamai Y et al. Characterization of mechanisms of fluconazole resistance in a Candida albicans isolate from a Japanese patient with chronic mucocutaneous candidiasis. 2004 Microbiol. Immunol. pmid:15611610
Belviso S et al. Lipid nutrition of Saccharomyces cerevisiae in winemaking. 2004 Can. J. Microbiol. pmid:15644919
Batrakov SG et al. Lipids of the zygomycete Absidia corymbifera F-965. 2004 Phytochemistry pmid:15184008
Martin SW and Konopka JB Lipid raft polarization contributes to hyphal growth in Candida albicans. 2004 Eukaryotic Cell pmid:15189988
Kasparovsky T et al. Ergosterol elicits oxidative burst in tobacco cells via phospholipase A2 and protein kinase C signal pathway. 2004 Plant Physiol. Biochem. pmid:15191747
Guarino AJ et al. Cholesterol crystal nucleation from enzymatically modified low-density lipoproteins: combined effect of sphingomyelinase and cholesterol esterase. 2004 Biochemistry pmid:14769046
Branco MR et al. Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. 2004 J. Biol. Chem. pmid:14645222
Khajuria RK et al. Separation, identification, and quantification of selected withanolides in plant extracts of Withania somnifera by HPLC-UV(DAD)--positive ion electrospray ionisation-mass spectrometry. 2004 J Sep Sci pmid:15335037
Mohan R et al. Withaferin A is a potent inhibitor of angiogenesis. 2004 Angiogenesis pmid:15516832
Choudhary MI et al. Cholinesterase inhibiting withanolides from Withania somnifera. 2004 Chem. Pharm. Bull. pmid:15520512
Mille-Lindblom C et al. Ergosterol as a measure of living fungal biomass: persistence in environmental samples after fungal death. 2004 J. Microbiol. Methods pmid:15369861
Hippelein M and Rügamer M Ergosterol as an indicator of mould growth on building materials. 2004 Int J Hyg Environ Health pmid:15471102
Pierson CA et al. Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans. 2004 Med. Mycol. pmid:15473366
Mathur S et al. The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5beta, 6beta-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model. 2004 Phytomedicine pmid:15330502
Cornelius ML et al. Effect of a lignin-degrading fungus on feeding preferences of Formosan subterranean termite (Isoptera: Rhinotermitidae) for different commercial lumber. 2004 J. Econ. Entomol. pmid:15279287