Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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What lipids are associated with Ergosterol?

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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
BERGMANN W and KLACSMANN JA Ergosterol F. 1948 J. Org. Chem. pmid:18917704
Abramovitch A and Le Quesne PW Steroidal adducts. VI. Steroids as probes of the relative reactivities of enophiles and dienophiles. Reactions of dicyanoacetylene with ergosterol derivatives. 1974 J. Org. Chem. pmid:4854408
O'Keeffe J et al. Exposure of the yeast Candida albicans to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B. 2003 J. Pharm. Pharmacol. pmid:14738588
Payne NI et al. In-vivo studies of amphotericin B liposomes derived from proliposomes: effect of formulation on toxicity and tissue disposition of the drug in mice. 1987 J. Pharm. Pharmacol. pmid:2880979
Sajbidor J et al. Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. 1998 J. Pharm. Pharmacol. pmid:9600722
Uma Devi P and Kamath R Radiosensitizing effect of withaferin A combined with hyperthermia on mouse fibrosarcoma and melanoma. 2003 J. Radiat. Res. pmid:12841592
Sliwowski JK and Caspi E Synthesis of ergostane derivatives oxygenated in ring D. 1977 J. Steroid Biochem. pmid:916670
Agarwal VK A new procedure for the isomerization of vitamin D and its metabolites. 1990 J. Steroid Biochem. pmid:2155346
Seamark DA et al. A new procedure for the formation of isotachysterol derivatives of subnanomole quantities of ergocalciferol, cholecalciferol and its metabolites prior to gas liquid chromatography. 1980 J. Steroid Biochem. pmid:6252388
Zhao G and Simpson RU Interaction between vitamin D receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin D3 in adult rat cardiomyocytes. 2010 J. Steroid Biochem. Mol. Biol. pmid:20304057
Jacquier N and Schneiter R Mechanisms of sterol uptake and transport in yeast. 2012 J. Steroid Biochem. Mol. Biol. pmid:21145395
Kristan K and Rižner TL Steroid-transforming enzymes in fungi. 2012 J. Steroid Biochem. Mol. Biol. pmid:21946531
Mason RS et al. Photoprotection by 1alpha,25-dihydroxyvitamin D and analogs: further studies on mechanisms and implications for UV-damage. 2010 J. Steroid Biochem. Mol. Biol. pmid:20399269
Porter JR et al. Identifying a static nonlinear structure in a biological system using noisy, sparse data. 2012 J. Theor. Biol. pmid:22310068
DeCaprio AP et al. Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat. 2009 J. Toxicol. Environ. Health Part A pmid:19557614
Jasinghe VJ et al. Vitamin D2 from irradiated mushrooms significantly increases femur bone mineral density in rats. 2006 J. Toxicol. Environ. Health Part A pmid:16982536
Poole JA et al. Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts. 2010 J. Toxicol. Environ. Health Part A pmid:20391112
Sekiya T and Nozawa Y Reorganization of membrane ergosterol during cell fission events of Candida albicans: a freeze-fracture study of distribution of filipin-ergosterol complexes. 1983 J. Ultrastruct. Res. pmid:6343625
Nishiyama Y [Structure of fungi and the action mechanism of antifungal agents]. 2002 Jpn J Antibiot pmid:12664930
Hiratani T and Yamaguchi H [Cross-resistance of Candida albicans to several different families of antifungals with ergosterol biosynthesis-inhibiting activity]. 1994 Jpn J Antibiot pmid:8151906
Zhang X et al. Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism. 2015 Kobe J Med Sci pmid:26628015
Schiffman FJ and Vistica DT Membrane manipulation and cancer chemotherapy. 1977 Lancet pmid:64671
Vanegas JM et al. Influence of ethanol on lipid/sterol membranes: phase diagram construction from AFM imaging. 2010 Langmuir pmid:20518564
Neumann A et al. Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer. 2016 Langmuir pmid:27007267
Foglia F et al. Interaction of amphotericin B with lipid monolayers. 2014 Langmuir pmid:25019324
Melcion D et al. Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme. 1997 Lett. Appl. Microbiol. pmid:9134779
Jelen HH et al. Influence of octanoic acid addition to medium on some volatile compounds and PR-toxin biosynthesis by Penicillium roqueforti. 2002 Lett. Appl. Microbiol. pmid:12081547
Ng HE et al. Estimation of fungal growth using the ergosterol assay: a rapid tool in assessing the microbiological status of grains and feeds. 2008 Lett. Appl. Microbiol. pmid:18086192
Gutarowska B and Zakowska Z Mathematical models of mycelium growth and ergosterol synthesis in stationary mould culture. 2009 Lett. Appl. Microbiol. pmid:19291213
Silva EM et al. Effect of cereal brans on Lentinula edodes growth and enzyme activities during cultivation on forestry waste. 2005 Lett. Appl. Microbiol. pmid:15752219
Nam KS et al. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes. 2001 Life Sci. pmid:11441913
Rocha DD et al. Selective cytotoxicity of withaphysalins in myeloid leukemia cell lines versus peripheral blood mononuclear cells. 2006 Life Sci. pmid:16824549
Jayaprakasam B et al. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. 2003 Life Sci. pmid:14575818
Pierce AM et al. Identification of ergosta-8,24(28)-dien-3 beta,6 alpha-diol in A delta 8 goes to delta 7 sterol isomerase-blocked yeast mutant. 1979 Lipids pmid:388135
Ashman WH et al. Cloning and disruption of the yeast C-8 sterol isomerase gene. 1991 Lipids pmid:1779709
Kircher HW and Rosenstein FU Reaction of ergosteryl acetate with maleic anhydride and preparation of 5,7-ergostadien-3beta-ol1,2. 1975 Lipids pmid:1177664
Adler JH et al. Determination of the absolute configuration at C-20 and C-24 of ergosterol in Ascomycetes and Basidiomycetes by proton magnetic resonance spectroscopy. 1977 Lipids pmid:853879
M'Baya B et al. Regulation of squalene synthetase and squalene epoxidase activities in Saccharomyces cerevisiae. 1989 Lipids pmid:2693869
Safe S and Brewer D Lipid composition of Chaetomium cochliodes: effect of media. 1973 Lipids pmid:4713379
Kircher HW A facile synthesis of ergostanol. 1974 Lipids pmid:4418372
Song Z and Nes WD Sterol biosynthesis inhibitors: potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase. 2007 Lipids pmid:17393207
McIntosh AL et al. Fluorescence techniques using dehydroergosterol to study cholesterol trafficking. 2008 Lipids pmid:18536950
Nes WR et al. Evidence for facilitated transport in the absorption of sterols by Saccharomyces cerevisiae. 1986 Lipids pmid:3515094
Parks LW et al. An essential fungal growth factor derived from ergosterol: a new end product of sterol biosynthesis in fungi? 1986 Lipids pmid:3515097
McIntosh AL et al. Structure of dehydroergosterol monohydrate and interaction with sterol carrier protein-2. 2008 Lipids pmid:19020914
Ladevèze V et al. General resistance to sterol biosynthesis inhibitors in Saccharomyces cerevisiae. 1993 Lipids pmid:8246690
Kanagasabai R et al. Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain. 2004 Lipids pmid:15638241
Valachovic M et al. A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. 2004 Lipids pmid:15638242
Bard M et al. Sterol mutants of Saccharomyces cerevisiae: chromatographic analyses. 1977 Lipids pmid:331007
Hays PR et al. Accumulation of ergosta-8,14-dien-3beta-ol by Saccharomyces cerevisiae cultured with an azasterol antimycotic agent. 1977 Lipids pmid:331008
Greenspan MD and Mackow RC The effct of cerulenin on sterol biosynthesis in Saccharomyces cerevisiae. 1977 Lipids pmid:333217
Gao H et al. New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system. 2010 Magn Reson Chem pmid:19877128
Zhang YM et al. Ergosterols from the Culture Broth of Marine Streptomyces anandii H41-59. 2016 Mar Drugs pmid:27153073
Pereira DM et al. Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells. 2014 Mar Drugs pmid:24368569
May Zin WW et al. New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702. 2016 Mar Drugs pmid:27447650
Song J et al. The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. 2016 MBio pmid:26908577
Qin L et al. Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa. 2017 MBio pmid:28420736
Term 2. 2014 Med Mycol J pmid:24943213
Kametani T and Furuyama H Synthesis of vitamin D3 and related compounds. 1987 Apr-Jun Med Res Rev pmid:3033409
Ferreira ME et al. The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus. 2005 Med. Mycol. pmid:16110826
Favre B et al. Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates. 2004 Med. Mycol. pmid:15682641
de Oliveira Pereira F et al. Investigation on mechanism of antifungal activity of eugenol against Trichophyton rubrum. 2013 Med. Mycol. pmid:23181601
Arikan S Current status of antifungal susceptibility testing methods. 2007 Med. Mycol. pmid:17885947
De Lucca AJ et al. D-cecropin B: proteolytic resistance, lethality for pathogenic fungi and binding properties. 2000 Med. Mycol. pmid:10975698
Pierson CA et al. Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase. 2004 Med. Mycol. pmid:15552648
Niwano Y et al. Inhibition of sterol 14 alpha-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. 1999 Med. Mycol. pmid:10520160
Kim N et al. The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans. 2013 Med. Mycol. pmid:22662760
Semis R et al. Mechanism of activity and toxicity of Nystatin-Intralipid. 2013 Med. Mycol. pmid:23088298
Hata M et al. Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. 2010 Med. Mycol. pmid:20392153
Song JL et al. Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans. 2003 Med. Mycol. pmid:14653518
De Lucca AJ et al. Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin. 1998 Med. Mycol. pmid:10075498
Pierson CA et al. Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans. 2004 Med. Mycol. pmid:15473366
Vinarov A and Sidorenko T Biosynthesis of ergosterol by yeast Candida. 2001 Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet pmid:15954616
Turrens JF et al. [Subcellular distribution of ergosterol and 5,7-diene sterols in Trypanosoma cruzi]. 1980 Medicina (B Aires) pmid:7005595
Urbina JA Ergosterol biosynthesis and drug development for Chagas disease. 2009 Mem. Inst. Oswaldo Cruz pmid:19753490
Souza CM et al. A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance. 2011 Metab. Eng. pmid:21741494
Zuckermann MJ et al. Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts. 2004 Meth. Enzymol. pmid:15063652
Rodriguez RJ and Parks LW High-performance liquid chromatography of sterols: yeast sterols. 1985 Meth. Enzymol. pmid:3897778
Cohen FS and Niles WD Reconstituting channels into planar membranes: a conceptual framework and methods for fusing vesicles to planar bilayer phospholipid membranes. 1993 Meth. Enzymol. pmid:7688845
Woodbury DJ Nystatin/ergosterol method for reconstituting ion channels into planar lipid bilayers. 1999 Meth. Enzymol. pmid:9916236
Maxfield FR and Wüstner D Analysis of cholesterol trafficking with fluorescent probes. 2012 Methods Cell Biol. pmid:22325611
Quail MA and Kelly SL The extraction and analysis of sterols from yeast. 1996 Methods Mol. Biol. pmid:8924974
McIntosh AL et al. Multiphoton laser-scanning microscopy and spatial analysis of dehydroergosterol distributions on plasma membrane of living cells. 2007 Methods Mol. Biol. pmid:18214376
Chong PL and Olsher M Fluorometric assay for detection of sterol oxidation in liposomal membranes. 2007 Methods Mol. Biol. pmid:17951732
Yamamoto K et al. Enhancement of astaxanthin production in Xanthophyllomyces dendrorhous by efficient method for the complete deletion of genes. 2016 Microb. Cell Fact. pmid:27624332
Baumann K et al. Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. 2011 Microb. Cell Fact. pmid:22050768
Matsushika A et al. Transcription analysis of recombinant industrial and laboratory Saccharomyces cerevisiae strains reveals the molecular basis for fermentation of glucose and xylose. 2014 Microb. Cell Fact. pmid:24467867
Trikka FA et al. Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production. 2015 Microb. Cell Fact. pmid:25903744
Fu Z et al. Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. 2014 Microb. Cell Fact. pmid:24593159
Krogerus K et al. Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids. 2017 Microb. Cell Fact. pmid:28431563
Yuan J and Ching CB Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae. 2015 Microb. Cell Fact. pmid:25889168
Park S and Perlin DS Establishing surrogate markers for fluconazole resistance in Candida albicans. 2005 Microb. Drug Resist. pmid:16201925
Kaufman MG et al. Leaf-associated bacterial and fungal taxa shifts in response to larvae of the tree hole mosquito, Ochlerotatus triseriatus. 2008 Microb. Ecol. pmid:17899246
Boëchat IG et al. Sterol composition of freshwater algivorous ciliates does not resemble dietary composition. 2007 Microb. Ecol. pmid:17186159
Bastida F et al. Long-term effect of municipal solid waste amendment on microbial abundance and humus-associated enzyme activities under semiarid conditions. 2008 Microb. Ecol. pmid:17768652
Manerkar MA et al. Q-RT-PCR for assessing archaea, bacteria, and fungi during leaf decomposition in a stream. 2008 Microb. Ecol. pmid:18264658
Tintino SR et al. Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps. 2017 Microb. Pathog. pmid:28088472
Sardi JC et al. Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. 2017 Microb. Pathog. pmid:28259673
Shreaz S et al. Anticandidal activity of cinnamaldehyde, its ligand and Ni(II) complex: effect of increase in ring and side chain. 2010 Microb. Pathog. pmid:20399846
Ahmad A et al. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. 2010 Microb. Pathog. pmid:19835945