Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ergosterol

Download all related citations
Per page 10 20 50 100 | Total 2233
Authors Title Published Journal PubMed Link
Ye M et al. (24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells. 2013 Nat. Prod. Res. pmid:22889249
Fan J et al. Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. 2013 New Phytol. pmid:23442154
Elschner T et al. Syntheses and detailed structure characterization of dextran carbonates. 2013 Carbohydr Polym pmid:23465922
Chen YL et al. Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. 2013 PLoS ONE pmid:23472097
Leefmann T et al. Spectral characterization of ten cyclic lipids using time-of-flight secondary ion mass spectrometry. 2013 Rapid Commun. Mass Spectrom. pmid:23413216
Müller C et al. A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis. 2013 Steroids pmid:23454215
Tanaka AR et al. p38MAPK and Rho-dependent kinase are involved in anoikis induced by anicequol or 25-hydroxycholesterol in DLD-1 colon cancer cells. 2013 Biochem. Biophys. Res. Commun. pmid:23266613
Zavrel M et al. Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. 2013 Eukaryotic Cell pmid:23475705
Brilhante RS et al. Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in Coccidioides posadasii. 2013 Antimicrob. Agents Chemother. pmid:23459491
Robalo JR et al. Behavior of fluorescent cholesterol analogues dehydroergosterol and cholestatrienol in lipid bilayers: a molecular dynamics study. 2013 J Phys Chem B pmid:23597397
Lafleur MD et al. Potentiation of azole antifungals by 2-adamantanamine. 2013 Antimicrob. Agents Chemother. pmid:23689724
Campos-Bermudez VA et al. Transcriptional and metabolic changes associated to the infection by Fusarium verticillioides in maize inbreds with contrasting ear rot resistance. 2013 PLoS ONE pmid:23637860
Iwaki A et al. Vanillin inhibits translation and induces messenger ribonucleoprotein (mRNP) granule formation in saccharomyces cerevisiae: application and validation of high-content, image-based profiling. 2013 PLoS ONE pmid:23637899
Tesnière C et al. Impact of nutrient imbalance on wine alcoholic fermentations: nitrogen excess enhances yeast cell death in lipid-limited must. 2013 PLoS ONE pmid:23658613
Georgiev AG et al. Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport. 2013 Traffic pmid:23668914
Cvelbar D et al. Steroid toxicity and detoxification in ascomycetous fungi. 2013 Chem. Biol. Interact. pmid:23257178
Jiang C et al. Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. 2013 J. Antimicrob. Chemother. pmid:23221625
Pacheco A et al. C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. 2013 PLoS ONE pmid:24040213
South PF et al. H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23382196
Tung NT et al. Inhibitory effect on NO production of triterpenes from the fruiting bodies of Ganoderma lucidum. 2013 Bioorg. Med. Chem. Lett. pmid:23357630
Wu SJ et al. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. 2013 Am. J. Chin. Med. pmid:23336512
Davey ML et al. Amplicon-pyrosequencing-based detection of compositional shifts in bryophyte-associated fungal communities along an elevation gradient. 2013 Mol. Ecol. pmid:23190367
Sun N et al. Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants. 2013 Antimicrob. Agents Chemother. pmid:23147730
de Oliveira Pereira F et al. Investigation on mechanism of antifungal activity of eugenol against Trichophyton rubrum. 2013 Med. Mycol. pmid:23181601
Bitencourt TA et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. 2013 BMC Complement Altern Med pmid:24044691
Liu X et al. Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum. 2013 Mol. Plant Pathol. pmid:22947191
Henderson CM et al. Fermentation temperature modulates phosphatidylethanolamine and phosphatidylinositol levels in the cell membrane of Saccharomyces cerevisiae. 2013 Appl. Environ. Microbiol. pmid:23811519
Jost DI et al. Microbial biomass in faeces of dairy cows affected by a nitrogen deficient diet. 2013 Arch Anim Nutr pmid:23521691
Yasuda K et al. UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1. 2013 Biochem. Biophys. Res. Commun. pmid:23548573
Razzaghi-Abyaneh M et al. Effects of Heracleum persicum ethyl acetate extract on the growth, hyphal ultrastructure and aflatoxin biosynthesis in Aspergillus parasiticus. 2013 Mycotoxin Res pmid:23780853
Shinde RB et al. An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans. 2013 J. Gen. Appl. Microbiol. pmid:23759870
Rodrigues C et al. Effect of forced aeration on citric acid production by Aspergillus sp. mutants in SSF. 2013 World J. Microbiol. Biotechnol. pmid:23760557
MikhaÄ­lova EV et al. [The effects of RH 421 on the activity of amphotericin B in cell and model membranes]. 2013 Tsitologiia pmid:23718076
Fangkrathok N et al. Bioactive ergostanoids and a new polyhydroxyoctane from Lentinus polychrous mycelia and their inhibitory effects on E2-enhanced cell proliferation of T47D cells. 2013 Nat. Prod. Res. pmid:23163256
Chen Y et al. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. 2013 J. Med. Microbiol. pmid:23657528
Thomas E et al. Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans. 2013 Antimicrob. Agents Chemother. pmid:23979757
Prasad R and Singh A Lipids of Candida albicans and their role in multidrug resistance. 2013 Curr. Genet. pmid:23974286
Onishi M and Kamimori H High-throughput and sensitive assay for amphotericin B interaction with lipid membrane on the model membrane systems by surface plasmon resonance. 2013 Biol. Pharm. Bull. pmid:23546296
Vincent BM et al. Fitness trade-offs restrict the evolution of resistance to amphotericin B. 2013 PLoS Biol. pmid:24204207
Zhang CY et al. Chemical constituents from an endophytic fungus Chaetomium globosum Z1. 2013 Nat Prod Commun pmid:24273849
Pasricha S et al. Cell-type-specific transcriptional profiles of the dimorphic pathogen Penicillium marneffei reflect distinct reproductive, morphological, and environmental demands. 2013 G3 (Bethesda) pmid:24062530
Chang J et al. The molecular mechanism of a cis-regulatory adaptation in yeast. 2013 PLoS Genet. pmid:24068973
Cao CM et al. Withanolide artifacts formed in methanol. 2013 J. Nat. Prod. pmid:24152046
Hill JA et al. Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. 2013 PLoS Genet. pmid:23593013
Morioka S et al. Effect of sterol composition on the activity of the yeast G-protein-coupled receptor Ste2. 2013 Appl. Microbiol. Biotechnol. pmid:23053114
Su TR et al. 5alpha,8alpha-epidioxysterols from a Formosan sponge, Axinyssa sp. 2013 Nat Prod Commun pmid:24427934
Clark KE et al. Ecology- and bioassay-guided drug discovery for treatments of tropical parasitic disease: 5alpha,8alpha-epidioxycholest-6-en-3beta-ol isolated from the mollusk Dolabrifera dolabrifera shows significant activity against Leishmania donovani. 2013 Nat Prod Commun pmid:24427935
Neumann A et al. The effect of sterols on amphotericin B self-aggregation in a lipid bilayer as revealed by free energy simulations. 2013 Biophys. J. pmid:23561525
Nicotra VE et al. Withanolides with phytotoxic activity from two species of the genus Salpichroa: S. origanifolia and S. tristis var. lehmannii. 2013 J. Nat. Prod. pmid:24303781
Crabbé A et al. Spaceflight enhances cell aggregation and random budding in Candida albicans. 2013 PLoS ONE pmid:24324620
Malmierca MG et al. Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum. 2013 Fungal Genet. Biol. pmid:23454546
Kim N et al. The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans. 2013 Med. Mycol. pmid:22662760
Semis R et al. Mechanism of activity and toxicity of Nystatin-Intralipid. 2013 Med. Mycol. pmid:23088298
König M et al. Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase. 2013 Bioorg. Med. Chem. pmid:23433667
Sørensen JL and Giese H Influence of carbohydrates on secondary metabolism in Fusarium avenaceum. 2013 Toxins (Basel) pmid:24064720
Liu J et al. Exogenous ergosterol protects Saccharomyces cerevisiae from D-limonene stress. 2013 J. Appl. Microbiol. pmid:23082823
Xiao L et al. Characterization of the high cytochalasin E and rosellichalasin producing-Aspergillus sp. nov. F1 isolated from marine solar saltern in China. 2013 World J. Microbiol. Biotechnol. pmid:22910972
Cirlini M et al. Durum wheat (Triticum Durum Desf.) lines show different abilities to form masked mycotoxins under greenhouse conditions. 2014 Toxins (Basel) pmid:24368326
Blosser SJ et al. Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. 2014 Microbiology (Reading, Engl.) pmid:25107308
Dinesh N et al. Exploring Leishmania donovani 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) as a potential drug target by biochemical, biophysical and inhibition studies. 2014 Microb. Pathog. pmid:24239940
Van Hauwenhuyse F et al. Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2. 2014 Eukaryotic Cell pmid:25084864
Wang Y et al. Investigating migration inhibition and apoptotic effects of Fomitopsis pinicola chloroform extract on human colorectal cancer SW-480 cells. 2014 PLoS ONE pmid:24992193
Term 2. 2014 Med Mycol J pmid:24943213
Cardoza RE et al. Overexpression of erg1 gene in Trichoderma harzianum CECT 2413: effect on the induction of tomato defence-related genes. 2014 J. Appl. Microbiol. pmid:24925373
Freires Ide A et al. Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression. 2014 PLoS ONE pmid:24901768
Whaley SG et al. UPC2A is required for high-level azole antifungal resistance in Candida glabrata. 2014 Antimicrob. Agents Chemother. pmid:24867980
Mpofu LT and McLaren NW Ergosterol concentration and variability in genotype-by-pathogen interaction for grain mold resistance in sorghum. 2014 Planta pmid:24817586
Nagy G et al. Transcription of the three HMG-CoA reductase genes of Mucor circinelloides. 2014 BMC Microbiol. pmid:24731286
Fügi MA et al. Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. 2014 J. Lipid Res. pmid:24627128
Ghelardi E et al. Potential of Ergosterol synthesis inhibitors to cause resistance or cross-resistance in Trichophyton rubrum. 2014 Antimicrob. Agents Chemother. pmid:24614379
Choi H et al. Residential culturable fungi, (1-3, 1-6)-β-d-glucan, and ergosterol concentrations in dust are not associated with asthma, rhinitis, or eczema diagnoses in children. 2014 Indoor Air pmid:24016225
Gu M et al. Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells. 2014 Invest New Drugs pmid:23887853
Ruiz M et al. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. 2014 FASEB J. pmid:24361577
He WS et al. Efficient synthesis and characterization of ergosterol laurate in a solvent-free system. 2014 J. Agric. Food Chem. pmid:25405492
Licursi V et al. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. 2014 FEBS J. pmid:24164706
Tong S et al. Simultaneous HPLC determination of ergosterol and 22,23-dihydroergosterol in Flammulina velutipes sterol-loaded microemulsion. 2014 Biomed. Chromatogr. pmid:23996456
Piłsyk S et al. Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei. 2014 Gene pmid:24793581
Dinesh N et al. Mianserin, an antidepressant kills Leishmania donovani by depleting ergosterol levels. 2014 Exp. Parasitol. pmid:24950381
Hu X et al. Ergosterol reverses multidrug resistance in SGC7901/Adr cells. 2014 Pharmazie pmid:24855835
Zhang X et al. Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours. 2014 Br. J. Cancer pmid:24983364
Tugizimana F et al. Multi-platform metabolomic analyses of ergosterol-induced dynamic changes in Nicotiana tabacum cells. 2014 PLoS ONE pmid:24498209
Qiao X et al. Separation of 25R/S-ergostane triterpenoids in the medicinal mushroom Antrodia camphorata using analytical supercritical-fluid chromatography. 2014 J Chromatogr A pmid:25017395
Ren B et al. ABC transporters coupled with the elevated ergosterol contents contribute to the azole resistance and amphotericin B susceptibility. 2014 Appl. Microbiol. Biotechnol. pmid:24435642
Caspeta L et al. Biofuels. Altered sterol composition renders yeast thermotolerant. 2014 Science pmid:25278608
Cheng C and Kao KC Microbiology. How to survive being hot and inebriated. 2014 Science pmid:25278598
Benaim G et al. Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy. 2014 Antimicrob. Agents Chemother. pmid:24492373
Pereira DM et al. Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells. 2014 Mar Drugs pmid:24368569
Yadav B et al. First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans. 2014 J. Biol. Chem. pmid:24356967
Nakagawa Y et al. Effect of sterol side chain on ion channel formation by amphotericin B in lipid bilayers. 2014 Biochemistry pmid:24762132
Ueda Y et al. Anti-HCV activity of the Chinese medicinal fungus Cordyceps militaris. 2014 Biochem. Biophys. Res. Commun. pmid:24726408
McCulley A et al. Chemical suppression of defects in mitotic spindle assembly, redox control, and sterol biosynthesis by hydroxyurea. 2014 G3 (Bethesda) pmid:24192836
Kuml D et al. Spiculisporic acid E, a new spiculisporic acid derivative and ergosterol derivatives from the marine-sponge associated fungus Talaromyces trachyspermus (KUFA 0021). 2014 Nat Prod Commun pmid:25233594
Norbäck D et al. Endotoxin, ergosterol, fungal DNA and allergens in dust from schools in Johor Bahru, Malaysia- associations with asthma and respiratory infections in pupils. 2014 PLoS ONE pmid:24523884
Chen YF et al. Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis. 2014 Biochem. Pharmacol. pmid:25076381
Fu Z et al. Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process. 2014 Microb. Cell Fact. pmid:24593159
Waśkiewicz A et al. Deoxynivalenol and oxidative stress indicators in winter wheat inoculated with Fusarium graminearum. 2014 Toxins (Basel) pmid:24514944
Pereira DM et al. Anti-inflammatory effect of unsaturated fatty acids and Ergosta-7,22-dien-3-ol from Marthasterias glacialis: prevention of CHOP-mediated ER-stress and NF-κB activation. 2014 PLoS ONE pmid:24551093
Cheng SM et al. Two new compounds from Bombyx batryticatus. 2014 J Asian Nat Prod Res pmid:24827605
Ostroumova OS et al. The interaction of dipole modifiers with amphotericin-ergosterol complexes. Effects of phospholipid and sphingolipid membrane composition. 2014 Eur. Biophys. J. pmid:24563224
Foglia F et al. Interaction of amphotericin B with lipid monolayers. 2014 Langmuir pmid:25019324