Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Penman CS and Duffus JH Accumulation of ergosterol during the cell cycle of the budding yeast Kluyveromyces fragilis. 1976 Z. Allg. Mikrobiol. pmid:983132
Müller H and Voigt B [Determination of free and bound ergosterol in microorganisms]. 1984 Z. Allg. Mikrobiol. pmid:6719940
Liu DZ et al. A new ergostane triterpenoid from a solid culture of the basidiomycete Inocybe lilacina. 2014 Mar-Apr Z. Naturforsch., C, J. Biosci. pmid:24873028
Sabir F et al. In vitro withanolide production by Withania somnifera L. cultures. 2008 May-Jun Z. Naturforsch., C, J. Biosci. pmid:18669028
Tabakova S et al. Anticandidial effect of phenylbutene derivatives and their interaction with ergosterol. 1999 Jan-Feb Z. Naturforsch., C, J. Biosci. pmid:10097407
Shimizu B et al. Phytotoxic components produced by pathogenic Fusarium against morning glory. 2005 Nov-Dec Z. Naturforsch., C, J. Biosci. pmid:16402546
KEINING E and BRETT R [Not Available]. 1949 Zentralbl Haut Geschlechtskr Grenzgeb pmid:18128414
Müller HM and Boley A [Effects of autoclaving and surface disinfection of wheat (Triticum aestivum) on the production of ergosterol, ochratoxin A and citrinin by Penicillium verrucosum]. 1991 Zentralbl. Mikrobiol. pmid:1950201
Müller HM and Boley A Studies on the refrigerated storage of wheat (Triticum aestivum). 2. Ergosterol, xanthomegnin, viomellein and brevianamide A after inoculation with Penicillium viridicatum. 1993 Zentralbl. Mikrobiol. pmid:8237145
Yang RY et al. [Study on the sterols from a brown alga endophytic fungus (NO. ZZF36) from the South China Sea]. 2006 Zhong Yao Cai pmid:17212043