MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Tinea | D014005 | 5 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Tinea | D014005 | 5 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Schneiter R et al. | Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. | 1999 | J. Cell Biol. | pmid:10459010 |
Swan TM and Watson K | Stress tolerance in a yeast lipid mutant: membrane lipids influence tolerance to heat and ethanol independently of heat shock proteins and trehalose. | 1999 | Can. J. Microbiol. | pmid:10453475 |
Kelly SL et al. | The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10448088 |
Wrenn SP et al. | A fluorescence energy transfer study of lecithin-cholesterol vesicles in the presence of phospholipase C. | 1999 | J. Lipid Res. | pmid:10428985 |
Vauthrin S et al. | Elicitins trap and transfer sterols from micelles, liposomes and plant plasma membranes. | 1999 | Biochim. Biophys. Acta | pmid:10407084 |
Siau H and Kerridge D | 5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata. | 1999 | J. Antimicrob. Chemother. | pmid:10404315 |
Boissy G et al. | The 2.1 A structure of an elicitin-ergosterol complex: a recent addition to the Sterol Carrier Protein family. | 1999 | Protein Sci. | pmid:10386869 |
Lin CY et al. | Inhibition of activated human mesangial cell proliferation by the natural product of Cordyceps sinensis (H1-A): an implication for treatment of IgA mesangial nephropathy. | 1999 | J. Lab. Clin. Med. | pmid:10385482 |
Piecková E and Jesenská Z | Microscopic fungi in dwellings and their health implications in humans. | 1999 | Ann Agric Environ Med | pmid:10384209 |
Park KS et al. | Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. | 1999 | J. Antimicrob. Chemother. | pmid:10382888 |