Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Wu QP et al. Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance. 2012 PLoS ONE pmid:22952996
Krumpe K et al. Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. 2012 Mol. Biol. Cell pmid:22918956
Cheng Z Interaction of ergosterol with bovine serum albumin and human serum albumin by spectroscopic analysis. 2012 Mol. Biol. Rep. pmid:22733490
te Welscher YM et al. Polyene antibiotic that inhibits membrane transport proteins. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22733749
Müller ME et al. Cocultivation of phytopathogenic Fusarium and Alternaria strains affects fungal growth and mycotoxin production. 2012 J. Appl. Microbiol. pmid:22776416
Davey ML et al. Seasonal trends in the biomass and structure of bryophyte-associated fungal communities explored by 454 pyrosequencing. 2012 New Phytol. pmid:22758207
Zhao YY et al. Ultra performance liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization (ESCi)-quadrupole time-of-flight mass spectrometry with novel mass spectrometry(Elevated Energy) (MS(E)) data collection technique: determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat. 2012 J Sep Sci pmid:22761140
Zhu ZY et al. Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis. 2012 J Asian Nat Prod Res pmid:22428587
Chen YY et al. Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways. 2012 Phytomedicine pmid:22464013
Piérard GE et al. Miconazole, a pharmacological barrier to skin fungal infections. 2012 Expert Opin Pharmacother pmid:22568580
Berner C et al. Long-term effect of apatite on ectomycorrhizal growth and community structure. 2012 Mycorrhiza pmid:22451218
Liu L et al. Solvent effect on the absorption and fluorescence of ergone: determination of ground and excited state dipole moments. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22047993
Virág E et al. In vivo direct interaction of the antibiotic primycin on a Candida albicans clinical isolate and its ergosterol-less mutant. 2012 Acta. Biol. Hung. pmid:22453799
Bastos AE et al. Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. 2012 Chem. Phys. Lipids pmid:22705749
Jacquier N and Schneiter R Mechanisms of sterol uptake and transport in yeast. 2012 J. Steroid Biochem. Mol. Biol. pmid:21145395
Suzuki G et al. A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress. 2012 Science pmid:22517861
Karunakaran S et al. SNAREs, HOPS and regulatory lipids control the dynamics of vacuolar actin during homotypic fusion in S. cerevisiae. 2012 J. Cell. Sci. pmid:22357954
Tao X et al. A novel strategy to construct yeast Saccharomyces cerevisiae strains for very high gravity fermentation. 2012 PLoS ONE pmid:22363590
Lieu MH et al. Mechanisms underlying stage-1 TRPL channel translocation in Drosophila photoreceptors. 2012 PLoS ONE pmid:22363689
Victoria GS et al. Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans. 2012 Biochem. J. pmid:22390164
Liu L et al. Scabronine M, a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells from the fungus Sarcodon scabrosus. 2012 Bioorg. Med. Chem. Lett. pmid:22401866
Rodríguez-Rodríguez CE et al. Removal of pharmaceuticals, polybrominated flame retardants and UV-filters from sludge by the fungus Trametes versicolor in bioslurry reactor. 2012 J. Hazard. Mater. pmid:22840500
Song MH et al. A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 2012 Eukaryotic Cell pmid:22080454
Ramos-Ligonio A et al. Trypanocidal activity of ergosterol peroxide from Pleurotus ostreatus. 2012 Phytother Res pmid:22083593
Rocha DD et al. Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens. 2012 Invest New Drugs pmid:21416228
Yan GL et al. Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae. 2012 Curr. Microbiol. pmid:22086347
Cateni F et al. Bioactive lipids metabolites in Amanita virosa. 2012 Nat Prod Commun pmid:23285815
López P and Martín J Chemosensory exploration of male scent by female rock lizards result from multiple chemical signals of males. 2012 Chem. Senses pmid:21743096
Avtonomova AV et al. [Submerged cultivation and chemical composition of Hericium erinaceus mycelium]. 2012 Antibiot. Khimioter. pmid:23350189
GagoÅ› M and Arczewska M FTIR spectroscopic study of molecular organization of the antibiotic amphotericin B in aqueous solution and in DPPC lipid monolayers containing the sterols cholesterol and ergosterol. 2012 Eur. Biophys. J. pmid:22832948
Wilcock BC et al. Electronic tuning of site-selectivity. 2012 Nat Chem pmid:23174979
Santos JR et al. Dynamic interaction between fluconazole and amphotericin B against Cryptococcus gattii. 2012 Antimicrob. Agents Chemother. pmid:22290956
Zhang BY et al. Chemical constituents of Euphorbia tangutica. 2012 Nat. Prod. Res. pmid:22424102
Szponar B et al. Bacterial and fungal markers in tobacco smoke. 2012 Sci. Total Environ. pmid:23026151
Rodríguez-Rodríguez CE et al. Bioaugmentation of sewage sludge with Trametes versicolor in solid-phase biopiles produces degradation of pharmaceuticals and affects microbial communities. 2012 Environ. Sci. Technol. pmid:23030544
Du YC et al. Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. 2012 Phytomedicine pmid:22516893
Loto I et al. Enhancement of carotenoid production by disrupting the C22-sterol desaturase gene (CYP61) in Xanthophyllomyces dendrorhous. 2012 BMC Microbiol. pmid:23075035
Noël T The cellular and molecular defense mechanisms of the Candida yeasts against azole antifungal drugs. 2012 J Mycol Med pmid:23518020
Yokoyama S et al. Osteoclastogenesis inhibitory effect of ergosterol peroxide isolated from Pleurotus eryngii. 2012 Nat Prod Commun pmid:23074896
Waskiewicz A et al. Kinetics of fumonisin B₁ formation in maize ears inoculated with Fusarium verticillioides. 2012 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:22916862
Koolen HH et al. An antimicrobial diketopiperazine alkaloid and co-metabolites from an endophytic strain of Gliocladium isolated from Strychnos cf. toxifera. 2012 Nat. Prod. Res. pmid:22117164
Kalaras MD et al. Generation of potentially bioactive ergosterol-derived products following pulsed ultraviolet light exposure of mushrooms (Agaricus bisporus). 2012 Food Chem pmid:22868105
Lima IO et al. Anti-Candida albicans effectiveness of citral and investigation of mode of action. 2012 Pharm Biol pmid:23116193
Foglia F et al. Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes. 2012 Sci Rep pmid:23110248
Takami T et al. A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. 2012 PLoS ONE pmid:23145048
Miller MB et al. Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. 2012 J. Lipid Res. pmid:22591742
Hull CM et al. Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B. 2012 Antimicrob. Agents Chemother. pmid:22615281
Ta MT et al. Accumulation of squalene is associated with the clustering of lipid droplets. 2012 FEBS J. pmid:23013491
Kristan K and Rižner TL Steroid-transforming enzymes in fungi. 2012 J. Steroid Biochem. Mol. Biol. pmid:21946531
Du YC et al. Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata. 2012 J Pharm Biomed Anal pmid:21975021
Virág E et al. Direct in vivo interaction of the antibiotic primycin with the plasma membrane of Candida albicans: an EPR study. 2012 Biochim. Biophys. Acta pmid:21978596
Dhamgaye S et al. In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2. 2012 Antimicrob. Agents Chemother. pmid:22006003
Blosser SJ and Cramer RA SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). 2012 Antimicrob. Agents Chemother. pmid:22006005
Yibmantasiri P et al. Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. 2012 Mol Biosyst pmid:22271309
Tian J et al. The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus. 2012 PLoS ONE pmid:22272289
Martins CC et al. Multi-molecular markers and metals as tracers of organic matter inputs and contamination status from an Environmental Protection Area in the SW Atlantic (Laranjeiras Bay, Brazil). 2012 Sci. Total Environ. pmid:22244354
Lewis RE et al. How does antifungal pharmacology differ for mucormycosis versus aspergillosis? 2012 Clin. Infect. Dis. pmid:22247448
Virág E et al. Complex formation between primycin and ergosterol: entropy-driven initiation of modification of the fungal plasma membrane structure. 2012 J. Antibiot. pmid:22274705
Tugizimana F et al. Ergosterol-induced sesquiterpenoid synthesis in tobacco cells. 2012 Molecules pmid:22322447
Nasir MN and Besson F Interactions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers. 2012 Biochim. Biophys. Acta pmid:22306791
Gray KC et al. Amphotericin primarily kills yeast by simply binding ergosterol. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22308411
Barker BM et al. Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. 2012 BMC Genomics pmid:22309491
Porter JR et al. Identifying a static nonlinear structure in a biological system using noisy, sparse data. 2012 J. Theor. Biol. pmid:22310068
Fang Y et al. A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis. 2012 Antimicrob. Agents Chemother. pmid:22252817
Rhee YH et al. Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells. 2012 BMC Cancer pmid:22260501
Carrasco H et al. Antifungal activity of eugenol analogues. Influence of different substituents and studies on mechanism of action. 2012 Molecules pmid:22262200
Tuckey RC et al. Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol. 2012 Drug Metab. Dispos. pmid:22106170
Choi JN et al. Influence of iron regulation on the metabolome of Cryptococcus neoformans. 2012 PLoS ONE pmid:22911836
Martin G et al. Fungi, bacteria and soil pH: the oxalate-carbonate pathway as a model for metabolic interaction. 2012 Environ. Microbiol. pmid:22928486
Dadakova K et al. Elucidation of signaling molecules involved in ergosterol perception in tobacco. 2013 Plant Physiol. Biochem. pmid:24095918
Crahay C et al. Cryopreservation of ectomycorrhizal fungi has minor effects on root colonization of Pinus sylvestris plantlets and their subsequent nutrient uptake capacity. 2013 Mycorrhiza pmid:23455883
Kaneko Y et al. Real-time microscopic observation of Candida biofilm development and effects due to micafungin and fluconazole. 2013 Antimicrob. Agents Chemother. pmid:23459484
Tatsumi Y et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. 2013 Antimicrob. Agents Chemother. pmid:23459486
Petrik S et al. Utilization of hydrothermally pretreated wheat straw for production of bioethanol and carotene-enriched biomass. 2013 Bioresour. Technol. pmid:23434815
Sonego JM et al. Synthesis and antifungal activity of C-21 steroids with an aromatic D ring. 2013 Steroids pmid:23499954
Hirz M et al. A novel cholesterol-producing Pichia pastoris strain is an ideal host for functional expression of human Na,K-ATPase α3β1 isoform. 2013 Appl. Microbiol. Biotechnol. pmid:23955473
Dehedin A et al. The combined effects of water level reduction and an increase in ammonia concentration on organic matter processing by key freshwater shredders in alluvial wetlands. 2013 Glob Chang Biol pmid:23504834
Cardoso DR et al. Riboflavin-photosensitized oxidation is enhanced by conjugation in unsaturated lipids. 2013 J. Agric. Food Chem. pmid:23402498
Kang CK et al. Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae. 2013 Microbiology (Reading, Engl.) pmid:23475946
Valentín L et al. Mycoremediation of wood and soil from an old sawmill area contaminated for decades. 2013 J. Hazard. Mater. pmid:23832059
Wu SH et al. Two new steroids from an endophytic fungus Phomopsis sp. 2013 Chem. Biodivers. pmid:23847072
Šimová Z et al. The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. 2013 Yeast pmid:23606207
Eddouzi J et al. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. 2013 Antimicrob. Agents Chemother. pmid:23629718
Chiu YF et al. In vivo probing of the temperature responses of intracellular biomolecules in yeast cells by label-free Raman microspectroscopy. 2013 Chembiochem pmid:23630156
Österlund T et al. Mapping condition-dependent regulation of metabolism in yeast through genome-scale modeling. 2013 BMC Syst Biol pmid:23631471
Pinto E et al. Antifungal activity of Ferulago capillaris essential oil against Candida, Cryptococcus, Aspergillus and dermatophyte species. 2013 Eur. J. Clin. Microbiol. Infect. Dis. pmid:23619574
Rajput SB and Karuppayil SM β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans. 2013 Phytomedicine pmid:23123225
Zhang BB et al. Cytotoxic cholestane-type and ergostane-type steroids from the aerial parts of Euphorbia altotibetic. 2013 Steroids pmid:23131765
Debieu D et al. Role of sterol 3-ketoreductase sensitivity in susceptibility to the fungicide fenhexamid in Botrytis cinerea and other phytopathogenic fungi. 2013 Pest Manag. Sci. pmid:23139232
Herath HM et al. New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens. 2013 Nat. Prod. Res. pmid:23140424
Layer JV et al. Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway. 2013 Biochim. Biophys. Acta pmid:23022663
Cabral ME et al. Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification. 2013 Rev Iberoam Micol pmid:23069981
Clemmensen KE et al. Roots and associated fungi drive long-term carbon sequestration in boreal forest. 2013 Science pmid:23539604
Irshad M et al. Composition of Cassia fistula oil and its antifungal activity by disrupting ergosterol biosynthesis. 2013 Nat Prod Commun pmid:23513744
Gallo-Ebert C et al. The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression. 2013 J. Biol. Chem. pmid:24163365
Zheng J et al. Antimicrobial ergosteroids and pyrrole derivatives from halotolerant Aspergillus flocculosus PT05-1 cultured in a hypersaline medium. 2013 Extremophiles pmid:24030481
Moretti-Almeida G et al. The essential gene YMR134W from Saccharomyces cerevisiae is important for appropriate mitochondrial iron utilization and the ergosterol biosynthetic pathway. 2013 FEBS Lett. pmid:23892078
Upadhya R et al. Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence. 2013 Mol. Microbiol. pmid:23998805
Souza-Moreira TM et al. Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study. 2013 Molecules pmid:23839114
Cicogna F et al. Interaction of azole compounds with DOPC and DOPC/ergosterol bilayers by spin probe EPR spectroscopy: implications for antifungal activity. 2013 J Phys Chem B pmid:24032998