Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Barton DH and Patin H Chemistry of the tricarbonyliron complexes of calciferol and ergosterol. 1976 J. Chem. Soc. Perkin Trans. I pmid:1083856
Ohnuma N et al. Sterol constituents from two edible mushrooms, Lentinula edodes and Tricholoma matsutake. 2000 Chem. Pharm. Bull. pmid:10823718
Ohvo-Rekilä H et al. Cyclodextrin-catalyzed extraction of fluorescent sterols from monolayer membranes and small unilamellar vesicles. 2000 Chem. Phys. Lipids pmid:10823464
Wu SH et al. Two novel secoergosterols from the fungus Tylopilus plumbeoviolaceus. 2000 J. Nat. Prod. pmid:10785434
Habtemariam S et al. 17-Epiacnistin-A, a further withanolide from the leaves of Discopodium penninervium. 2000 J. Nat. Prod. pmid:10785427
Frolov A et al. High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single- and multiphoton fluorescence approach. 2000 J. Biol. Chem. pmid:10777574
Bammert GF and Fostel JM Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. 2000 Antimicrob. Agents Chemother. pmid:10770760
Inoue T et al. Cloning and characterization of a gene complementing the mutation of an ethanol-sensitive mutant of sake yeast. 2000 Biosci. Biotechnol. Biochem. pmid:10737174
Soustre I et al. Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. 2000 FEBS Lett. pmid:10734216
Löffler J et al. Phospholipid and sterol analysis of plasma membranes of azole-resistant Candida albicans strains. 2000 FEMS Microbiol. Lett. pmid:10731607