MeSH term | MeSH ID | Detail |
---|---|---|
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Song S et al. | [Conditions for extraction of ergosterol from fruits of Ganoderma lucidum using supercritical fluid extration]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19894506 |
Yu J et al. | [Steroidal constituents from Saussurea gossypiphora D. Don]. | 1991 | Zhongguo Zhong Yao Za Zhi | pmid:1786098 |
Liu JM et al. | [Chemical constituents of Cordyceps mililaris (L.) Link]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2597325 |
Chao JF et al. | [Chemical constituents from branch of Broussonetia papyrifera]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048607 |
Li JL et al. | [A comparative study on sterols of ethanol extract and water extract from Hericium erinaceus]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776329 |
Shen YX et al. | [Studies on the chemical constituents of Shiraia bambusicola]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776569 |
Xiao SY et al. | [Secondary metabolites of Gliocladium sp., a growth accelerating fungus for Anoectochilus roxburghii (Wall.) Lindl]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12528522 |
Cui D et al. | [Chemical constituents of Bulgaria inquinans (Fries)]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038915 |
Chai H et al. | [Constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038948 |
Guo S et al. | [Determination of sugar components in wild and cultured sclerotia of Grifola umbellata (pers. ex Fr.) Pilat at different ages]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1418531 |