Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Assato PA et al. Functional analysis of Paracoccidioides brasiliensis 14-3-3 adhesin expressed in Saccharomyces cerevisiae. 2015 BMC Microbiol. pmid:26537993
Leaver DJ et al. Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei. 2015 Chem. Biol. pmid:26496686
Gutiérrez MS et al. Molecular Characterization and Functional Analysis of Cytochrome b5 Reductase (CBR) Encoding Genes from the Carotenogenic Yeast Xanthophyllomyces dendrorhous. 2015 PLoS ONE pmid:26466337
Helliwell SB et al. FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. 2015 Nat Commun pmid:26456460
Paiva Rde O et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. 2015 BMC Microbiol. pmid:25649493
Steudler S et al. Biomass measurement by flow cytometry during solid-state fermentation of basidiomycetes. 2015 Cytometry A pmid:25475642
Haubrich BA et al. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. 2015 J. Lipid Res. pmid:25424002
Noh HJ et al. Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells. 2015 J Enzyme Inhib Med Chem pmid:25676326
Liu DZ et al. A new ergostane triterpenoid from a solid culture of the basidiomycete Inocybe lilacina. 2014 Mar-Apr Z. Naturforsch., C, J. Biosci. pmid:24873028
Wang M et al. Os2 MAP kinase-mediated osmostress tolerance in Penicillium digitatum is associated with its positive regulation on glycerol synthesis and negative regulation on ergosterol synthesis. 2014 Jul-Aug Microbiol. Res. pmid:24439827
Andrade-Pavón D et al. The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: a proposal as a therapeutic target and as a study model. 2014 Jan-Mar Rev Iberoam Micol pmid:24270073
Xu W et al. Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania. 2014 PLoS Pathog. pmid:25340392
Stuper-Szablewska K and Perkowski J Contamination of wheat grain with microscopic fungi and their metabolites in Poland in 2006-2009. 2014 Ann Agric Environ Med pmid:25292118
Markowicz P et al. A study on particles and some microbial markers in waterpipe tobacco smoke. 2014 Sci. Total Environ. pmid:25181042
Kamiński DM Recent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments. 2014 Eur. Biophys. J. pmid:25173562
Villares A et al. Storage temperature and UV-irradiation influence on the ergosterol content in edible mushrooms. 2014 Food Chem pmid:24206714
Liu DZ et al. A new ergostane triterpenoid from cultures of the basidiomycete Inocybe lilacina. 2014 Nat Prod Commun pmid:24689218
Grillitsch K et al. Isolation and characterization of the plasma membrane from the yeast Pichia pastoris. 2014 Biochim. Biophys. Acta pmid:24680652
Liu DZ A review of ergostane and cucurbitane triterpenoids of mushroom origin. 2014 Nat. Prod. Res. pmid:24673284
Kitchawalit S et al. A new benzyl ester and ergosterol derivatives from the fungus Gymnoascus reessii. 2014 Nat. Prod. Res. pmid:24708569