Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

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What functions are associated with Ergosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

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What genes are associated with Ergosterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
pmid:
Georgopapadakou NH Antifungals: mechanism of action and resistance, established and novel drugs. 1998 Curr. Opin. Microbiol. pmid:10066533
De Lucca AJ et al. Fungicidal and binding properties of the natural peptides cecropin B and dermaseptin. 1998 Med. Mycol. pmid:10075498
Tabakova S et al. Anticandidial effect of phenylbutene derivatives and their interaction with ergosterol. 1999 Jan-Feb Z. Naturforsch., C, J. Biosci. pmid:10097407
Kennedy MA et al. Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. 1999 Biochim. Biophys. Acta pmid:10209263
Kaur R and Bachhawat AK The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. 1999 Microbiology (Reading, Engl.) pmid:10220160
Dimster-Denk D et al. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. 1999 J. Lipid Res. pmid:10224154
Smriti SS et al. Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans. 1999 FEMS Microbiol. Lett. pmid:10227177
Opekarová M et al. Expression of eukaryotic plasma membrane transporter HUP1 from Chlorella kessleri in Escherichia coli. 1999 FEMS Microbiol. Lett. pmid:10234823
Daum G et al. Systematic analysis of yeast strains with possible defects in lipid metabolism. 1999 Yeast pmid:10341423