MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Regerat F et al. | [Investigation on ergosterol occurence in fruit bodies of some macromycetes]. | 1976 May-Jun | Ann Pharm Fr | pmid:999160 |
Ronis MJ et al. | Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by ergosterol biosynthesis inhibiting fungicides. | 1998 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9972464 |
Beuchet P et al. | Synthesis of 6(alpha, beta)-aminocholestanols as ergosterol biosynthesis inhibitors. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934483 |
Abramson D et al. | Relationships among deoxynivalenol, ergosterol and Fusarium exoantigens in Canadian hard and soft wheat. | 1998 | Int. J. Food Microbiol. | pmid:9926999 |
Denter J et al. | Changes in the contents of fat-soluble vitamins and provitamins during tempe fermentation. | 1998 | Int. J. Food Microbiol. | pmid:9924943 |
Woodbury DJ | Nystatin/ergosterol method for reconstituting ion channels into planar lipid bilayers. | 1999 | Meth. Enzymol. | pmid:9916236 |
Sandhoff R et al. | Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. | 1999 | J. Lipid Res. | pmid:9869658 |
Qian H and Sheng M | Simultaneous determination of fat-soluble vitamins A, D and E and pro-vitamin D2 in animal feeds by one-step extraction and high-performance liquid chromatography analysis. | 1998 | J Chromatogr A | pmid:9867394 |
el-Mekkawy S et al. | Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. | 1998 | Phytochemistry | pmid:9862140 |
Swan TM and Watson K | Stress tolerance in a yeast sterol auxotroph: role of ergosterol, heat shock proteins and trehalose. | 1998 | FEMS Microbiol. Lett. | pmid:9851052 |