Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ergosterol

Download all related citations
Per page 10 20 50 100 | Total 2233
Authors Title Published Journal PubMed Link
Regerat F et al. [Investigation on ergosterol occurence in fruit bodies of some macromycetes]. 1976 May-Jun Ann Pharm Fr pmid:999160
Ronis MJ et al. Cytochrome P450 enzymes in the kidney of the bobwhite quail (Colinus virginianus): induction and inhibition by ergosterol biosynthesis inhibiting fungicides. 1998 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:9972464
Beuchet P et al. Synthesis of 6(alpha, beta)-aminocholestanols as ergosterol biosynthesis inhibitors. 1998 Bioorg. Med. Chem. Lett. pmid:9934483
Abramson D et al. Relationships among deoxynivalenol, ergosterol and Fusarium exoantigens in Canadian hard and soft wheat. 1998 Int. J. Food Microbiol. pmid:9926999
Denter J et al. Changes in the contents of fat-soluble vitamins and provitamins during tempe fermentation. 1998 Int. J. Food Microbiol. pmid:9924943
Woodbury DJ Nystatin/ergosterol method for reconstituting ion channels into planar lipid bilayers. 1999 Meth. Enzymol. pmid:9916236
Sandhoff R et al. Determination of cholesterol at the low picomole level by nano-electrospray ionization tandem mass spectrometry. 1999 J. Lipid Res. pmid:9869658
Qian H and Sheng M Simultaneous determination of fat-soluble vitamins A, D and E and pro-vitamin D2 in animal feeds by one-step extraction and high-performance liquid chromatography analysis. 1998 J Chromatogr A pmid:9867394
el-Mekkawy S et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. 1998 Phytochemistry pmid:9862140
Swan TM and Watson K Stress tolerance in a yeast sterol auxotroph: role of ergosterol, heat shock proteins and trehalose. 1998 FEMS Microbiol. Lett. pmid:9851052
Disch A and Rohmer M On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. 1998 FEMS Microbiol. Lett. pmid:9835029
Penman CS and Duffus JH Accumulation of ergosterol during the cell cycle of the budding yeast Kluyveromyces fragilis. 1976 Z. Allg. Mikrobiol. pmid:983132
Honda M et al. Accurate detection of Smith-Lemli-Opitz syndrome carriers by measurement of the rate of reduction of the ergosterol C-7 double bond in cultured skin fibroblasts. 1998 J. Inherit. Metab. Dis. pmid:9819706
Wangspa R and Takemoto JY Role of ergosterol in growth inhibition of Saccharomyces cerevisiae by syringomycin E. 1998 FEMS Microbiol. Lett. pmid:9809422
Togashi H et al. 4-Hydroxy-17-methylincisterol, an inhibitor of DNA polymerase-alpha activity and the growth of human cancer cells in vitro. 1998 Biochem. Pharmacol. pmid:9783727
Navashin PS [Antifungal chemotherapy. Progress and problems]. 1998 Antibiot. Khimioter. pmid:9777098
Cotero BV et al. On the role of sterol in the formation of the amphotericin B channel. 1998 Biochim. Biophys. Acta pmid:9767100
Luo H et al. Study on kinetics of ergosterol fermentation. 1998 Chin. J. Biotechnol. pmid:9759546
Orozco AS et al. Mechanism of fluconazole resistance in Candida krusei. 1998 Antimicrob. Agents Chemother. pmid:9756770
Marr KA et al. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. 1998 Antimicrob. Agents Chemother. pmid:9756759
Mukherjee S et al. Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. 1998 Biophys. J. pmid:9746532
De Lucca AJ et al. Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1. 1998 Can. J. Microbiol. pmid:9734302
Fournier I et al. The structuring effects of amphotericin B on pure and ergosterol- or cholesterol-containing dipalmitoylphosphatidylcholine bilayers: a differential scanning calorimetry study. 1998 Biochim. Biophys. Acta pmid:9733926
Urbina JA et al. A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. 1998 Biophys. J. pmid:9726938
Crowley JH et al. A calcium-dependent ergosterol mutant of Saccharomyces cerevisiae. 1998 Curr. Genet. pmid:9724410
Wang MM et al. Role of the sterol superlattice in the partitioning of the antifungal drug nystatin into lipid membranes. 1998 Biochemistry pmid:9718302
Launhardt H et al. Drug-induced phenotypes provide a tool for the functional analysis of yeast genes. 1998 Yeast pmid:9717239
Tejada-Simon MV and Pestka JJ Production of polyclonal antibody against ergosterol hemisuccinate using Freund's and Titermax adjuvants. 1998 J. Food Prot. pmid:9713773
Vazquez JA et al. Stable phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azoles. 1998 J. Clin. Microbiol. pmid:9705415
Atta-ur-Rahman A et al. Two new ergostane-type steroidal lactones from Withania coagulans. 1998 J. Nat. Prod. pmid:9644072
Sugawara T et al. YM-170320, a novel lipopeptide antibiotic inducing morphological change of colonies in a mutant of Candida tropicalis pK233. 1998 J. Antibiot. pmid:9630867
Sajbidor J et al. Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. 1998 J. Pharm. Pharmacol. pmid:9600722
Shimonaka H et al. Altered microviscosity of in vivo lipid-manipulated membranes in Tetrahymena pyriformis: a fluorescence study. 1978 Experientia pmid:95966
Leyden J Pharmacokinetics and pharmacology of terbinafine and itraconazole. 1998 J. Am. Acad. Dermatol. pmid:9594936
Miura Y et al. Production of the carotenoids lycopene, beta-carotene, and astaxanthin in the food yeast Candida utilis. 1998 Appl. Environ. Microbiol. pmid:9546156
Ness F et al. Sterol uptake in Saccharomyces cerevisiae heme auxotrophic mutants is affected by ergosterol and oleate but not by palmitoleate or by sterol esterification. 1998 J. Bacteriol. pmid:9537392
Mikes V et al. Elicitins, proteinaceous elicitors of plant defense, are a new class of sterol carrier proteins. 1998 Biochem. Biophys. Res. Commun. pmid:9535796
Sgarbi DB et al. Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii. 1997 Mycopathologia pmid:9511231
Venkateswarlu K et al. The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. 1998 J. Biol. Chem. pmid:9468503
Brynjolffssen J et al. Unsaturated steroids. Part I. Synthesis of 22,23-dihydroergosterol. 1976 J. Chem. Soc. Perkin Trans. I pmid:944710
Barton DH et al. Synthetic use of steroidal ring B diene protection: 22,23-dihydroergosterol. 1976 J. Chem. Soc. Perkin Trans. I pmid:944709
Okeke BC et al. Comparative biotransformation of pentachlorophenol in soils by solid substrate cultures of Lentinula edodes. 1997 Appl. Microbiol. Biotechnol. pmid:9445539
Maiti RN et al. Effect of withafastuosin E on gastric mucosal offensive and defensive factors in rats. 1997 Indian J. Exp. Biol. pmid:9418376
Mikes V et al. The fungal elicitor cryptogein is a sterol carrier protein. 1997 FEBS Lett. pmid:9369212
Bhattacharya SK et al. Antioxidant activity of glycowithanolides from Withania somnifera. 1997 Indian J. Exp. Biol. pmid:9332168
Serra T and Polónia J Isolation of pinastric acid and ergosterol from Parmelia caperata (L.) Arch. 1976 J Pharm Sci pmid:932945
Igbavboa U et al. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. 1997 J. Neurochem. pmid:9326295
Albro PW et al. Photochemical reactions and phototoxicity of sterols: novel self-perpetuating mechanisms for lipid photooxidation. 1997 Photochem. Photobiol. pmid:9297976
Palermo LM et al. Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae. 1997 Curr. Genet. pmid:9294256
Donald KA et al. Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. 1997 Appl. Environ. Microbiol. pmid:9292983
Grebenok RJ et al. Characterization of Zea mays endosperm C-24 sterol methyltransferase: one of two types of sterol methyltransferase in higher plants. 1997 Plant Mol. Biol. pmid:9290641
Leber A et al. The yeast mic2 mutant is defective in the formation of mannosyl-diinositolphosphorylceramide. 1997 FEBS Lett. pmid:9271207
Arami S et al. Reduction of ATPase activity accompanied by photodecomposition of ergosterol by near-UV irradiation in plasma membranes prepared from Saccharomyces cerevisiae. 1997 Microbiology (Reading, Engl.) pmid:9245827
Ganasoundari A et al. Modification of bone marrow radiosensensitivity by medicinal plant extracts. 1997 Br J Radiol pmid:9227253
Venkateswarlu K et al. In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei. 1997 J. Antimicrob. Chemother. pmid:9222042
Baranova NA et al. [The growth of Rhodotorula rubra yeasts and their synthesis of ergosterol on media with lovastatin]. 1996 Antibiot. Khimioter. pmid:9214284
Saraf A et al. Quantification of ergosterol and 3-hydroxy fatty acids in settled house dust by gas chromatography-mass spectrometry: comparison with fungal culture and determination of endotoxin by a Limulus amebocyte lysate assay. 1997 Appl. Environ. Microbiol. pmid:9212406
Lamb DC et al. Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans. 1997 Antimicrob. Agents Chemother. pmid:9210667
Wang Q et al. Binding of vitamin D and cholesterol to beta-lactoglobulin. 1997 J. Dairy Sci. pmid:9201574
Venkateswarlu K and Kelly SL Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus. 1997 J. Antimicrob. Chemother. pmid:9184358
Arami S et al. Near-UV-induced absorbance change and photochemical decomposition of ergosterol in the plasma membrane of the yeast Saccharomyces cerevisiae. 1997 Microbiology (Reading, Engl.) pmid:9168615
Sliwowski JK and Caspi E Synthesis of ergostane derivatives oxygenated in ring D. 1977 J. Steroid Biochem. pmid:916670
Kuchta T et al. Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. 1997 FEMS Microbiol. Lett. pmid:9163904
van Erpecum KJ and Carey MC Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability. 1997 Biochim. Biophys. Acta pmid:9150247
Barwicz J and Tancrède P The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers. 1997 Chem. Phys. Lipids pmid:9138890
Melcion D et al. Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme. 1997 Lett. Appl. Microbiol. pmid:9134779
Liu F et al. Cholesterol and ergosterol superlattices in three-component liquid crystalline lipid bilayers as revealed by dehydroergosterol fluorescence. 1997 Biophys. J. pmid:9129827
Loura LM and Prieto M Dehydroergosterol structural organization in aqueous medium and in a model system of membranes. 1997 Biophys. J. pmid:9129825
Jonsson A et al. Electronic nose for microbial quality classification of grains. 1997 Int. J. Food Microbiol. pmid:9105927
Lopez-Diaz TM and Flannigan B Production of patulin and cytochalasin E by Aspergillus clavatus during malting of barley and wheat. 1997 Int. J. Food Microbiol. pmid:9105920
Kelly SL et al. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. 1997 J. Biol. Chem. pmid:9092539
Smith SJ and Parks LW Requirement of heme to replace the sparking sterol function in the yeast Saccharomyces cerevisiae. 1997 Biochim. Biophys. Acta pmid:9084503
Habtemariam S Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium. 1997 Planta Med. pmid:9063090
Devi PU Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization. 1996 Indian J. Exp. Biol. pmid:9055640
Diak J Investigation on some compounds biosynthesized by fruitbodies of Naematoloma fasciculare/huds. ex fr./p. Karst. 1977 Planta Med. pmid:905436
Leconte O et al. Protective effect of iridals from saponin injury in Candida albicans cells. 1997 Phytochemistry pmid:9041715
DeLucca AJ et al. Fungicidal activity of cecropin A. 1997 Antimicrob. Agents Chemother. pmid:9021214
Wheat J et al. Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum. 1997 Antimicrob. Agents Chemother. pmid:9021199
Miller JD and Young JC The use of ergosterol to measure exposure to fungal propagules in indoor air. 1997 Am Ind Hyg Assoc J pmid:9018836
Abecia LC et al. In vitro activity of fluconazole on Candida albicans. 1996 Microbiologia pmid:9018696
Daum G et al. Lipid metabolism in inositol-deficient yeast, Saccharomyces carlsbergensis. The influence of temperature and anaerobiosis on the cellular lipid composition. 1977 Biochim. Biophys. Acta pmid:901800
Sperry S and Crews P Haliclostanone sulfate and halistanol sulfate from an Indo-Pacific Haliclona sponge. 1997 J. Nat. Prod. pmid:9014348
Moebius FF et al. Yeast sterol C8-C7 isomerase: identification and characterization of a high-affinity binding site for enzyme inhibitors. 1996 Biochemistry pmid:8988026
Goldstein AS and Frye LL Synthesis and bioevaluation of delta 7-5-desaturase inhibitors, an enzyme late in the biosynthesis of the fungal sterol ergosterol. 1996 J. Med. Chem. pmid:8978840
Honda M et al. Measurement of 3 beta-hydroxysteroid delta 7-reductase activity in cultured skin fibroblasts utilizing ergosterol as a substrate: a new method for the diagnosis of the Smith-Lemli-Opitz syndrome. 1996 J. Lipid Res. pmid:8978494
Quail MA and Kelly SL The extraction and analysis of sterols from yeast. 1996 Methods Mol. Biol. pmid:8924974
Harki E et al. Identification and quantification of Tuber melanosporum Vitt. sterols. 1996 Steroids pmid:8910974
Frolov A et al. Fibroblast membrane sterol kinetic domains: modulation by sterol carrier protein-2 and liver fatty acid binding protein. 1996 J. Lipid Res. pmid:8895052
Brosa C et al. New synthetic strategy for the synthesis of 24-epibrassinolide. 1996 Steroids pmid:8883220
Barrett-Bee K and Dixon G Ergosterol biosynthesis inhibition: a target for antifungal agents. 1995 Acta Biochim. Pol. pmid:8852337
Goldman RC et al. Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors. 1996 Antimicrob. Agents Chemother. pmid:8849227
Smith SJ et al. Transcriptional regulation by ergosterol in the yeast Saccharomyces cerevisiae. 1996 Mol. Cell. Biol. pmid:8816455
Arthington-Skaggs BA et al. Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. 1996 FEBS Lett. pmid:8772195
Marcireau C et al. FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast. 1996 Yeast pmid:8771708
Venkateswarlu K et al. Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. 1996 Antimicrob. Agents Chemother. pmid:8726005
Tripathi YB and Shukla S Withaperuvin-E, a new free radical scavenger isolated from Physalis peruviana. 1995 Indian J. Biochem. Biophys. pmid:8713755
Hargreaves JA and Keon JP Isolation of an Ustilago maydis ERG11 gene and its expression in a mutant deficient in sterol 14 alpha-demethylase activity. 1996 FEMS Microbiol. Lett. pmid:8674989
Frolov A et al. Spontaneous and protein-mediated sterol transfer between intracellular membranes. 1996 J. Biol. Chem. pmid:8663152
Saito H et al. Physical states of surface and core lipids in lipid emulsions and apolipoprotein binding to the emulsion surface. 1996 J. Biol. Chem. pmid:8663047
Popp B et al. The role of the N and C termini of recombinant Neurospora mitochondrial porin in channel formation and voltage-dependent gating. 1996 J. Biol. Chem. pmid:8662769