Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ergosterol

Download all related citations
Per page 10 20 50 100 | Total 2233
Authors Title Published Journal PubMed Link
Dai J et al. Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. 2017 Oncotarget pmid:28099150
Cardoso NN et al. Anti-cryptococcal activity of ethanol crude extract and hexane fraction from Ocimum basilicum var. Maria bonita: mechanisms of action and synergism with amphotericin B and Ocimum basilicum essential oil. 2017 Pharm Biol pmid:28317465
Tintino SR et al. Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps. 2017 Microb. Pathog. pmid:28088472
de Sá NP et al. Effects of two 6-quinolinyl chalcones on the integrity of plasma membrane of Paracoccidioides brasiliensis. 2017 J. Antibiot. pmid:28074055
Zulueta Díaz YLM and Fanani ML Crossregulation between the insertion of Hexadecylphosphocholine (miltefosine) into lipid membranes and their rheology and lateral structure. 2017 Biochim. Biophys. Acta pmid:28642044
Zhang DH et al. Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi. 2017 Phytochemistry pmid:27894599
Ono J et al. Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment. 2017 PLoS Biol. pmid:28114370
Manik MK et al. Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction. 2017 Structure pmid:28319008
Favarin BZ et al. Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization. 2017 Colloids Surf B Biointerfaces pmid:28472750
Sardi JC et al. Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp. 2017 Microb. Pathog. pmid:28259673
Peixoto LR et al. Antifungal activity, mode of action and anti-biofilm effects of Laurus nobilis Linnaeus essential oil against Candida spp. 2017 Arch. Oral Biol. pmid:27771586
Gao Y et al. In Vitro and In Vivo Activity of Fomitopsis Pinicola (Sw. Ex Fr.) Karst Chloroform (Fpkc) Extract Against S180 Tumor Cells. 2017 Cell. Physiol. Biochem. pmid:29241162
Miller MB et al. 24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei. 2017 Biochim. Biophys. Acta pmid:27939999
Mwenechanya R et al. Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. 2017 PLoS Negl Trop Dis pmid:28622334
Ruan R et al. Functional analysis of two sterol regulatory element binding proteins in Penicillium digitatum. 2017 PLoS ONE pmid:28467453
Krogerus K et al. Inheritance of brewing-relevant phenotypes in constructed Saccharomyces cerevisiae × Saccharomyces eubayanus hybrids. 2017 Microb. Cell Fact. pmid:28431563
Qin L et al. Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa. 2017 MBio pmid:28420736
Stuper-Szablewska K and Perkowski J Level of contamination with mycobiota and contents of mycotoxins from the group of trichothecenes in grain of wheat , oats, barley, rye and triticale harvested in Poland in 2006- 2008. 2017 Ann Agric Environ Med pmid:28378974
Qi Y et al. Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. 2017 Appl. Environ. Microbiol. pmid:28710262
Lin M et al. Ergosteryl 2-naphthoate, An Ergosterol Derivative, Exhibits Antidepressant Effects Mediated by the Modification of GABAergic and Glutamatergic Systems. 2017 Molecules pmid:28362353
Karaca Gençer H et al. New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation. 2017 Molecules pmid:28346364
Kamthan A et al. Expression of C-5 sterol desaturase from an edible mushroom in fisson yeast enhances its ethanol and thermotolerance. 2017 PLoS ONE pmid:28278249
Iaea DB et al. Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane. 2017 Mol. Biol. Cell pmid:28209730
Sui G et al. Trialkylamine Derivatives Containing a Triazole Moiety as Promising Ergosterol Biosynthesis Inhibitor: Design, Synthesis, and Antifungal Activity. 2017 Chem. Pharm. Bull. pmid:28049918
Brilhante RS et al. Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi. 2016 Oct - Dec Braz. J. Microbiol. pmid:27520529
Feitosa AO et al. Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). 2016 Jul - Sep Rev. Argent. Microbiol. pmid:27567521
Hung WC et al. Comparative Study of the Condensing Effects of Ergosterol and Cholesterol. 2016 Biophys. J. pmid:27166810
Zhang YM et al. Ergosterols from the Culture Broth of Marine Streptomyces anandii H41-59. 2016 Mar Drugs pmid:27153073
Zhang HY et al. Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability. 2016 Acta Pharmacol. Sin. pmid:27133301
Zhuang Z et al. The Master Transcription Factor mtfA Governs Aflatoxin Production, Morphological Development and Pathogenicity in the Fungus Aspergillus flavus. 2016 Toxins (Basel) pmid:26805883
Ferrante T et al. Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells. 2016 Acta Biochim. Pol. pmid:27031513
Song J et al. The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. 2016 MBio pmid:26908577
Bojsen R et al. A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations. 2016 Sci Rep pmid:26903175
Han B et al. Antifungal activity of Rubus chingii extract combined with fluconazole against fluconazole-resistant Candida albicans. 2016 Microbiol. Immunol. pmid:26891940
Sugiura S and Mima J Physiological lipid composition is vital for homotypic ER membrane fusion mediated by the dynamin-related GTPase Sey1p. 2016 Sci Rep pmid:26838333
Bui DC et al. The FgNot3 Subunit of the Ccr4-Not Complex Regulates Vegetative Growth, Sporulation, and Virulence in Fusarium graminearum. 2016 PLoS ONE pmid:26799401
Zielińska J et al. Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail. 2016 Sci Rep pmid:26742886
Song XS et al. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. 2016 New Phytol. pmid:26720747
Cho SJ et al. Observational scores of dampness and mold associated with measurements of microbial agents and moisture in three public schools. 2016 Indoor Air pmid:25650175
Yoshioka M et al. The fungicidal activity of amphotericin B requires autophagy-dependent targeting to the vacuole under a nutrient-starved condition in Saccharomyces cerevisiae. 2016 Microbiology (Reading, Engl.) pmid:26940206
Gao T et al. The Fungicidal Activity of Thymol against Fusarium graminearum via Inducing Lipid Peroxidation and Disrupting Ergosterol Biosynthesis. 2016 Molecules pmid:27322238
Warrilow AG et al. The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. 2016 Antimicrob. Agents Chemother. pmid:27161631
Yamamoto K et al. Enhancement of astaxanthin production in Xanthophyllomyces dendrorhous by efficient method for the complete deletion of genes. 2016 Microb. Cell Fact. pmid:27624332
Neumann A et al. Membrane Sterols Modulate the Binding Mode of Amphotericin B without Affecting Its Affinity for a Lipid Bilayer. 2016 Langmuir pmid:27007267
Cordeiro Rde A et al. Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex. 2016 Microbiology (Reading, Engl.) pmid:26645478
Reis MP et al. Fisetin as a promising antifungal agent against Cryptocococcus neoformans species complex. 2016 J. Appl. Microbiol. pmid:27107205
Najle SR et al. Sterol metabolism in the filasterean Capsaspora owczarzaki has features that resemble both fungi and animals. 2016 Open Biol pmid:27383626
OuYang Q et al. Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral. 2016 BMC Genomics pmid:27514516
Valdez-Morales M et al. Phenolic Compounds, Antioxidant Activity and Lipid Profile of Huitlacoche Mushroom (Ustilago maydis) Produced in Several Maize Genotypes at Different Stages of Development. 2016 Plant Foods Hum Nutr pmid:27605221
May Zin WW et al. New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702. 2016 Mar Drugs pmid:27447650
Konecna A et al. ERG6 gene deletion modifies Kluyveromyces lactis susceptibility to various growth inhibitors. 2016 Yeast pmid:27668979
Adhikari K et al. Factors Affecting Enhanced Permeation of Amphotericin B Across Cell Membranes and Safety of Formulation. 2016 AAPS PharmSciTech pmid:26349688
Kinoshita H et al. Cryptic antifungal compounds active by synergism with polyene antibiotics. 2016 J. Biosci. Bioeng. pmid:26323525
Cordeiro Rde A et al. Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones against Coccidioides posadasii. 2016 Microb. Pathog. pmid:27334293
Nakagawa Y et al. The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores. 2016 Biochemistry pmid:27227740
Oblak E et al. Quaternary ammonium salt N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl ammonium chloride induced alterations in Saccharomyces cerevisiae physiology. 2016 J. Biosci. pmid:27966483
Fernando D et al. Cytotoxic effects of ergone, a compound isolated from Fulviformes fastuosus. 2016 BMC Complement Altern Med pmid:27887609
Dauchy FA et al. Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. 2016 PLoS Negl Trop Dis pmid:27855164
Nóbrega RO et al. Investigation of the antifungal activity of carvacrol against strains of Cryptococcus neoformans. 2016 Pharm Biol pmid:27225838
Taofiq O et al. Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties. 2016 Molecules pmid:27754433
DuBois JC and Smulian AG Sterol Regulatory Element Binding Protein (Srb1) Is Required for Hypoxic Adaptation and Virulence in the Dimorphic Fungus Histoplasma capsulatum. 2016 PLoS ONE pmid:27711233
Kuo YH et al. Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin. 2016 Molecules pmid:27626393
Xu YJ et al. Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway. 2016 Genetics pmid:27585850
Vazquez HM et al. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. 2016 PLoS Genet. pmid:27462707
Nowak R et al. A New Method for the Isolation of Ergosterol and Peroxyergosterol as Active Compounds of Hygrophoropsis aurantiaca and in Vitro Antiproliferative Activity of Isolated Ergosterol Peroxide. 2016 Molecules pmid:27455215
Moselhy SS et al. Possible inhibition of hydroxy methyl glutaryl CoA reductase activity by nicotinic acid and ergosterol: as targeting for hypocholesterolemic action. 2016 Afr Health Sci pmid:27358648
O'Meara TR et al. Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress. 2016 PLoS Genet. pmid:27341673
Lv QZ et al. The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn. 2016 Virulence pmid:27221657
Belaunzarán ML [Chagas disease: Globalization and new hope for its cure]. 2015 Apr-Jun Rev. Argent. Microbiol. pmid:26028584
Deng ZY et al. Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment. 2015 Inflamm. Res. pmid:25833014
Gutiérrez MS et al. Molecular Characterization and Functional Analysis of Cytochrome b5 Reductase (CBR) Encoding Genes from the Carotenogenic Yeast Xanthophyllomyces dendrorhous. 2015 PLoS ONE pmid:26466337
Helliwell SB et al. FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. 2015 Nat Commun pmid:26456460
Kodedová M and Sychrová H Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae. 2015 PLoS ONE pmid:26418026
Keller P et al. An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols. 2015 Antimicrob. Agents Chemother. pmid:26248360
de Macedo-Silva ST et al. Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis. 2015 Antimicrob. Agents Chemother. pmid:26239973
Ahluwalia V et al. Comparative evaluation of two Trichoderma harzianum strains for major secondary metabolite production and antifungal activity. 2015 Nat. Prod. Res. pmid:25248548
Luna-Tapia A et al. ERG2 and ERG24 Are Required for Normal Vacuolar Physiology as Well as Candida albicans Pathogenicity in a Murine Model of Disseminated but Not Vaginal Candidiasis. 2015 Eukaryotic Cell pmid:26231054
Kozajda AI et al. Assessment of exposure to fungi in the heavily contaminated work environment (a solid waste sorting plant) based on the ergosterol analysis. 2015 Int J Occup Med Environ Health pmid:26224493
Mathur R et al. Elevated ergosterol protects Leishmania parasites against antimony-generated stress. 2015 FASEB J. pmid:26116701
Bühler N et al. Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans. 2015 Eukaryotic Cell pmid:26116213
Li X et al. Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors. 2015 Oncotarget pmid:26098777
Pereira MG et al. Trypanosoma cruzi Epimastigotes Are Able to Manage Internal Cholesterol Levels under Nutritional Lipid Stress Conditions. 2015 PLoS ONE pmid:26068009
Davis SA et al. Nontoxic antimicrobials that evade drug resistance. 2015 Nat. Chem. Biol. pmid:26030729
Murley A et al. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. 2015 J. Cell Biol. pmid:25987606
NÃ¥bo LJ et al. Design of new fluorescent cholesterol and ergosterol analogs: Insights from theory. 2015 Biochim. Biophys. Acta pmid:25963993
Malmierca MG et al. Trichodiene Production in a Trichoderma harzianum erg1-Silenced Strain Provides Evidence of the Importance of the Sterol Biosynthetic Pathway in Inducing Plant Defense-Related Gene Expression. 2015 Mol. Plant Microbe Interact. pmid:26168138
Sterkenburg E et al. Changes in fungal communities along a boreal forest soil fertility gradient. 2015 New Phytol. pmid:25952659
Cardoza RE et al. Effects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum. 2015 Appl. Environ. Microbiol. pmid:26150463
Leiva K et al. Identification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesis. 2015 BMC Microbiol. pmid:25906980
McCall LI et al. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. 2015 PLoS Negl Trop Dis pmid:25768284
Ano Y et al. Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum. 2015 PLoS ONE pmid:25760331
Steudler S et al. Biomass measurement by flow cytometry during solid-state fermentation of basidiomycetes. 2015 Cytometry A pmid:25475642
Haubrich BA et al. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. 2015 J. Lipid Res. pmid:25424002
Ma B et al. Interference and Mechanism of Dill Seed Essential Oil and Contribution of Carvone and Limonene in Preventing Sclerotinia Rot of Rapeseed. 2015 PLoS ONE pmid:26133771
Kim SJ et al. Beneficial effects of the traditional medicine Igongsan and its constituent ergosterol on dextran sulfate sodium-induced colitis in mice. 2015 Mol Med Rep pmid:26005209
Trikka FA et al. Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production. 2015 Microb. Cell Fact. pmid:25903744
Su W et al. Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. 2015 PLoS ONE pmid:26098102
Monje-Galvan V and Klauda JB Modeling Yeast Organelle Membranes and How Lipid Diversity Influences Bilayer Properties. 2015 Biochemistry pmid:26497753
Yuan J and Ching CB Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae. 2015 Microb. Cell Fact. pmid:25889168
Ottaviano D et al. Unsaturated fatty acids-dependent linkage between respiration and fermentation revealed by deletion of hypoxic regulatory KlMGA2 gene in the facultative anaerobe-respiratory yeast Kluyveromyces lactis. 2015 FEMS Yeast Res. pmid:26019145