Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ergosterol

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Authors Title Published Journal PubMed Link
Ferber D Infectious disease. New weapons in the battle of the bugs. 2002 Science pmid:11799221
Zhang N et al. [Preparative isolation and purification of ergosterol from a strain of Paecilomyces hepialid by high-speed counter-current chromatography]. 2010 Se Pu pmid:20458924
Gao H and Tan TW [Analysis of parameters for optimum of ergosterol fermentation]. 2001 Sheng Wu Gong Cheng Xue Bao pmid:11910767
Fan N et al. [Enhanced ergosterol production by recombinant Saccharomyces cerevisiae 1190 harboring Vitreoscilla hemoglobin gene (vgb)]. 2004 Sheng Wu Gong Cheng Xue Bao pmid:15971621
Lei J et al. [Influence of floc size distribution on the ethanol tolerance of a self-flocculating yeast strain SPSC01]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:18464618
Liu L et al. Solvent effect on the absorption and fluorescence of ergone: determination of ground and excited state dipole moments. 2012 Spectrochim Acta A Mol Biomol Spectrosc pmid:22047993
Marxer MA and Studer-Stäheli C [Clinical study on the effectiveness of Insadol]. 1978 SSO Schweiz Monatsschr Zahnheilkd pmid:349689
Sjöstrand U et al. Minor and trace sterols from marine invertebrates 29. (22E)-ergosta-5,22,25-trien-3 beta-ol and (22E,24R)-24,26-dimethylcholesta-5,22,25(27)-trien-3 beta-ol. Two new marine sterols from the sponge Pseudaxinella lunacharta. 1981 Steroids pmid:7303039
Lees ND et al. Membrane fluidity alterations in a cytochrome P-450-deficient mutant of Candida albicans. 1989 Mar-May Steroids pmid:2552620
Sato S et al. Identification of 23-demethylacanthasterol in an asteroid, Acanthaster planci and its synthesis. 1980 Steroids pmid:6893371
Allevi P et al. Hydroboration of 5 alpha-ergost-8-en-3 beta-ol. 1989 Steroids pmid:2588293
Brosa C et al. New synthetic strategy for the synthesis of 24-epibrassinolide. 1996 Steroids pmid:8883220
Macías FA et al. Bioactive steroids from Oryza sativa L. 2006 Steroids pmid:16620896
Zhang Y et al. Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger. 2007 Steroids pmid:17628622
Mehdi H et al. Sterols of Acanthamoeba culbertsoni strain A-1. 1988 May-Jun Steroids pmid:3242176
Malik S and Djerassi C Minor and trace sterols in marine invertebrates. 61. Isolation and structure elucidation of new A-nor sterols from the marine sponge Phakellia aruensis. 1989 Mar-May Steroids pmid:2799846
Mercer EI et al. Effect of some sterol-biosynthesis-inhibiting fungicides on the biosynthesis of polyisoprenoid compounds in barley seedings. 1989 Mar-May Steroids pmid:2799851
Wang F and Liu JK Two new steryl esters from the basidiomycete Tricholomopsis rutilans. 2005 Steroids pmid:15631869
Fuska J et al. Microbial transformations of natural antitumor agents. 23. Conversion of withaferin-A to 12 beta- and 15 beta-hydroxy derivatives of withaferin-A. 1982 Steroids pmid:7157453
Stonard RJ et al. A new C26 sterol peroxide from the opisthobranch mollusk Adalaria sp. and the sea pen Virgularia sp. 1980 Steroids pmid:7414658