| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Tinea | D014005 | 5 associated lipids |
| Mycoses | D009181 | 18 associated lipids |
Total
4
Ergosterol
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ergosterol?
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ergosterol
PubChem Associated disorders and diseases
What pathways are associated with Ergosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ergosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ergosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ergosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ergosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ergosterol?
Knock-out
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ergosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakanishi T | [Search for and structural elucidation of medicinal products from the vegetable kingdom (crude drugs and plant materials)]. | 2007 | Yakugaku Zasshi | pmid:18057787 |
| Li P et al. | [Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurized solvent extraction and high performance liquid chromatography]. | 2004 | Yao Xue Xue Bao | pmid:15696933 |
| Li YH and Li XL | [Determination of ergosterol in Cordyceps sinensis and Cordyceps black-bone chicken capsules by HPLC]. | 1991 | Yao Xue Xue Bao | pmid:1823719 |
| Marisco G et al. | Low ergosterol content in yeast adh1 mutant enhances chitin maldistribution and sensitivity to paraquat-induced oxidative stress. | 2011 | Yeast | pmid:21360751 |
| Šimová Z et al. | The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. | 2013 | Yeast | pmid:23606207 |
| Ahmad A et al. | Antifungal activity of Coriaria nepalensis essential oil by disrupting ergosterol biosynthesis and membrane integrity against Candida. | 2011 | Yeast | pmid:21755533 |
| Lewis TL et al. | Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism. | 1988 | Yeast | pmid:3059715 |
| Jiang B et al. | A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. | 1994 | Yeast | pmid:8017104 |
| Warringer J and Blomberg A | Involvement of yeast YOL151W/GRE2 in ergosterol metabolism. | 2006 | Yeast | pmid:16598690 |
| Rautio JJ et al. | Monitoring yeast physiology during very high gravity wort fermentations by frequent analysis of gene expression. | 2007 | Yeast | pmid:17605133 |
| Konecna A et al. | ERG6 gene deletion modifies Kluyveromyces lactis susceptibility to various growth inhibitors. | 2016 | Yeast | pmid:27668979 |
| Smith SJ and Parks LW | The ERG3 gene in Saccharomyces cerevisiae is required for the utilization of respiratory substrates and in heme-deficient cells. | 1993 | Yeast | pmid:8109167 |
| Arneborg N et al. | The effect of ethanol and specific growth rate on the lipid content and composition of Saccharomyces cerevisiae grown anaerobically in a chemostat. | 1995 | Yeast | pmid:8533470 |
| Daum G et al. | Systematic analysis of yeast strains with possible defects in lipid metabolism. | 1999 | Yeast | pmid:10341423 |
| Jung WH et al. | Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans. | 2005 | Yeast | pmid:15789349 |
| Launhardt H et al. | Drug-induced phenotypes provide a tool for the functional analysis of yeast genes. | 1998 | Yeast | pmid:9717239 |
| Marcireau C et al. | FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast. | 1996 | Yeast | pmid:8771708 |
| Tomeo ME et al. | Effect of sterol alterations on conjugation in Saccharomyces cerevisiae. | 1992 | Yeast | pmid:1293881 |
| Penman CS and Duffus JH | Accumulation of ergosterol during the cell cycle of the budding yeast Kluyveromyces fragilis. | 1976 | Z. Allg. Mikrobiol. | pmid:983132 |
| Müller H and Voigt B | [Determination of free and bound ergosterol in microorganisms]. | 1984 | Z. Allg. Mikrobiol. | pmid:6719940 |