Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ergosterol?

Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ergosterol

PubChem Associated disorders and diseases

What pathways are associated with Ergosterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ergosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ergosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ergosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ergosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ergosterol?

Knock-out

Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ergosterol

Download all related citations
Per page 10 20 50 100 | Total 2233
Authors Title Published Journal PubMed Link
Liu XT et al. Antibacterial compounds from mushrooms II: lanostane triterpenoids and an ergostane steroid with activity against Bacillus cereus isolated from Fomitopsis pinicola. 2010 Planta Med. pmid:19847745
Neumann A et al. How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its membrane targets. 2010 J. Am. Chem. Soc. pmid:21126070
Zhao YY et al. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats. 2010 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19944658
Gao H et al. New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system. 2010 Magn Reson Chem pmid:19877128
Zhang N et al. [Preparative isolation and purification of ergosterol from a strain of Paecilomyces hepialid by high-speed counter-current chromatography]. 2010 Se Pu pmid:20458924
Zhao G and Simpson RU Interaction between vitamin D receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin D3 in adult rat cardiomyocytes. 2010 J. Steroid Biochem. Mol. Biol. pmid:20304057
Prasad T et al. Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. 2010 FEMS Yeast Res. pmid:20491944
Covino S et al. Inoculum carrier and contaminant bioavailability affect fungal degradation performances of PAH-contaminated solid matrices from a wood preservation plant. 2010 Chemosphere pmid:20299070
Landolfo S et al. Oleic acid and ergosterol supplementation mitigates oxidative stress in wine strains of Saccharomyces cerevisiae. 2010 Int. J. Food Microbiol. pmid:20626100
Klose C et al. Yeast lipids can phase-separate into micrometer-scale membrane domains. 2010 J. Biol. Chem. pmid:20647309
Miao L et al. Reduction of fatty acid flux results in enhancement of astaxanthin synthesis in a mutant strain of Phaffia rhodozyma. 2010 J. Ind. Microbiol. Biotechnol. pmid:20229332
Vanegas JM et al. Influence of ethanol on lipid/sterol membranes: phase diagram construction from AFM imaging. 2010 Langmuir pmid:20518564
Moliné M et al. Photoprotection by carotenoid pigments in the yeast Rhodotorula mucilaginosa: the role of torularhodin. 2010 Photochem. Photobiol. Sci. pmid:20571712
Patil SP et al. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. 2010 J. Nat. Prod. pmid:20553006
Wallander H et al. Production of ectomycorrhizal mycelium peaks during canopy closure in Norway spruce forests. 2010 New Phytol. pmid:20561206
Day JP et al. Label-free imaging of lipophilic bioactive molecules during lipid digestion by multiplex coherent anti-Stokes Raman scattering microspectroscopy. 2010 J. Am. Chem. Soc. pmid:20507119
Tejada M et al. Application of MCPA herbicide on soils amended with biostimulants: short-time effects on soil biological properties. 2010 Chemosphere pmid:20510432
Zhang YQ et al. Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. 2010 PLoS Pathog. pmid:20532216
Parkinson DR et al. Analysis of ergosterol for the detection of mold in soils by automated on-fiber derivatization headspace extraction-SPME-GC/MS. 2010 Anal. Chim. Acta pmid:20113733
Aguilar PS et al. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20150508
Nussbaum K et al. Trypanosomatid parasites causing neglected diseases. 2010 Curr. Med. Chem. pmid:20166934
Hata M et al. In vitro and in vivo antifungal activities of aminopiperidine derivatives, novel ergosterol synthesis inhibitors. 2010 Biol. Pharm. Bull. pmid:20190412
Kumar R et al. Drawida willsi Michalsen activates cellulolysis in pressmud vermireactor. 2010 Bioresour. Technol. pmid:20675126
Gamarra S et al. Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans. 2010 Antimicrob. Agents Chemother. pmid:20194694
Martel CM et al. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. 2010 Antimicrob. Agents Chemother. pmid:20733039
Hoehamer CF et al. Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents. 2010 Antimicrob. Agents Chemother. pmid:20145080
Martel CM et al. Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. 2010 Antimicrob. Agents Chemother. pmid:20733045
Stefani FO et al. Impact of endochitinase-transformed white spruce on soil fungal biomass and ectendomycorrhizal symbiosis. 2010 Appl. Environ. Microbiol. pmid:20173071
Szwajkowska-Michalek L et al. Contents of microscopic fungi in dusts coming from cereal analysis laboratories. 2010 Ann Agric Environ Med pmid:20684486
Rice C et al. A role for MGA2, but not SPT23, in activation of transcription of ERG1 in Saccharomyces cerevisiae. 2010 Biochem. Biophys. Res. Commun. pmid:21075079
Wu SJ et al. Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. 2010 J. Nat. Prod. pmid:21028898
Li X et al. Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses. 2010 Cell pmid:21035178
Becker JM et al. Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:21135205
Song YX et al. [Secondary metabolites of mangrove endophytic fungus BL321 in the South China Sea]. 2010 Zhong Yao Cai pmid:21049610
Wüstner D et al. Selective visualization of fluorescent sterols in Caenorhabditis elegans by bleach-rate-based image segmentation. 2010 Traffic pmid:20070610
Pramanik P Changes in microbial properties and nutrient dynamics in bagasse and coir during vermicomposting: quantification of fungal biomass through ergosterol estimation in vermicompost. 2010 Waste Manag pmid:20061132
Qiao MF et al. Asporyergosterol, a new steroid from an algicolous isolate of Aspergillus oryzae. 2010 Nat Prod Commun pmid:21121251
Brumfield KM et al. Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. 2010 PLoS ONE pmid:20084111
Kim SD Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum. 2010 J. Microbiol. Biotechnol. pmid:21124056
Chi F et al. Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells. 2010 Biochem. J. pmid:20088823
Grover A et al. Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A. 2010 BMC Genomics pmid:21143809
Kageyama-Yahara N et al. The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells. 2010 Biol. Pharm. Bull. pmid:20045953
Zhao J et al. Antimicrobial metabolites from the endophytic fungus Pichia guilliermondii isolated from Paris polyphylla var. yunnanensis. 2010 Molecules pmid:21060302
Xia XK et al. [Study on the second metabolisms from fungus HS-1 Epicoccum spp. from the sea cucumber in Yellow Sea]. 2010 Zhong Yao Cai pmid:21355195
Cui YJ et al. Cytotoxicity of 9,11-dehydroergosterol peroxide isolated from Ganoderma lucidum and its target-related proteins. 2010 Nat Prod Commun pmid:20839614
Porter JR et al. Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. 2010 J. Biol. Chem. pmid:20959444
Shao S et al. Ergosterol profiles, fatty acid composition, and antioxidant activities of button mushrooms as affected by tissue part and developmental stage. 2010 J. Agric. Food Chem. pmid:20961043
Kunoh T et al. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. 2010 Mol. Cancer Ther. pmid:20978158
Khan A et al. Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. 2010 Res. Microbiol. pmid:20868749
Synnott JM et al. Regulation of the hypoxic response in Candida albicans. 2010 Eukaryotic Cell pmid:20870877
Szablewski T et al. Ergosterol as an indicator of the presence of microscopic fungi in eggs for human consumption produced in different husbandry systems. 2010 Poult. Sci. pmid:20952713
Zhou X et al. Dynamic lipidomic insights into the adaptive responses of Saccharomyces cerevisiae to the repeated vacuum fermentation. 2010 OMICS pmid:20955009
te Welscher YM et al. Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. 2010 Antimicrob. Agents Chemother. pmid:20385867
Gallo MB et al. Chemical constituents of Papulaspora immersa, an endophyte from Smallanthus sonchifolius (Asteraceae), and their cytotoxic activity. 2010 Chem. Biodivers. pmid:21162007
Jia L et al. [Studies on the chemical constituents from petroleum ether portion of Abelmoschus esculentus]. 2010 Zhong Yao Cai pmid:21213539
Ogita A et al. Dependence of vacuole disruption and independence of potassium ion efflux in fungicidal activity induced by combination of amphotericin B and allicin against Saccharomyces cerevisiae. 2010 J. Antibiot. pmid:20940723
Weng Y et al. Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. 2010 Bioorg. Med. Chem. pmid:20093034
Suttana W et al. Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. 2010 Mol. Cancer pmid:20438634
Yu Y et al. Withaferin A targets heat shock protein 90 in pancreatic cancer cells. 2010 Biochem. Pharmacol. pmid:19769945
Shimizu K et al. Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane. 2010 J Control Release pmid:19815038
Hsueh YW et al. Deuterium NMR study of the effect of ergosterol on POPE membranes. 2010 Biophys. J. pmid:20371320
Cheng MJ et al. Secondary metabolites from the red mould rice of Monascus purpureus BCRC 38113. 2010 Nat. Prod. Res. pmid:19459082
Mannock DA et al. A calorimetric and spectroscopic comparison of the effects of ergosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. 2010 Biochim. Biophys. Acta pmid:19761759
Xu JW et al. Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum. 2010 Appl. Microbiol. Biotechnol. pmid:19578843
Otero JM et al. Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications. 2010 BMC Genomics pmid:21176163
Baird TD and DeLorenzo ME Descriptive and mechanistic toxicity of conazole fungicides using the model test alga Dunaliella tertiolecta (Chlorophyceae). 2010 Environ. Toxicol. pmid:19382186
Rodríguez-Rodríguez CE et al. Naproxen degradation test to monitor Trametes versicolor activity in solid-state bioremediation processes. 2010 J. Hazard. Mater. pmid:20347219
Nagella P and Murthy HN Establishment of cell suspension cultures of Withania somnifera for the production of withanolide A. 2010 Bioresour. Technol. pmid:20371175
Zhao J et al. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. 2010 Genomics pmid:20206679
Zheng H et al. TOP2 gene disruption reduces drug susceptibility by increasing intracellular ergosterol biosynthesis in Candida albicans. 2010 J. Med. Microbiol. pmid:20223895
Jeon OY and Carreira EM Differential interaction of an AmB analogue and ergosterol in enantiomeric membranes. 2010 Org. Lett. pmid:20337425
Nakase M et al. Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe. 2010 J. Cell. Sci. pmid:20388730
Poole JA et al. Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts. 2010 J. Toxicol. Environ. Health Part A pmid:20391112
Hata M et al. Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. 2010 Med. Mycol. pmid:20392153
Dohnal V et al. Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process. 2010 Anal Bioanal Chem pmid:20225055
Wang H et al. Effects of storage condition factors on fungal invasion of Radix Ophiopogonis. 2010 J. Agric. Food Chem. pmid:20397649
Tewtrakul S et al. Anti-inflammatory principles from Heritiera littoralis bark. 2010 Phytomedicine pmid:20363114
Swasono RT et al. Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance. 2010 Bioorg. Med. Chem. Lett. pmid:20207137
Dovbnya DV et al. Microbial side-chain degradation of ergosterol and its 3-substituted derivatives: a new route for obtaining of deltanoids. 2010 Steroids pmid:20385161
Mason RS et al. Photoprotection by 1alpha,25-dihydroxyvitamin D and analogs: further studies on mechanisms and implications for UV-damage. 2010 J. Steroid Biochem. Mol. Biol. pmid:20399269
Shreaz S et al. Anticandidal activity of cinnamaldehyde, its ligand and Ni(II) complex: effect of increase in ring and side chain. 2010 Microb. Pathog. pmid:20399846
Ahmad A et al. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. 2010 Microb. Pathog. pmid:19835945
Patil D et al. Physicochemical stability and biological activity of Withania somnifera extract under real-time and accelerated storage conditions. 2010 Planta Med. pmid:19844862
Pramanik P Changes in enzymatic activities and microbial properties in vermicompost of water hyacinth as affected by pre-composting and fungal inoculation: a comparative study of ergosterol and chitin for estimating fungal biomass. 2010 Aug-Sep Waste Manag pmid:20303251
Kumar R and Shukla PK Amphotericin B resistance leads to enhanced proteinase and phospholipase activity and reduced germ tube formation in Candida albicans. 2010 Feb-Mar Fungal Biol pmid:20943129
Ferguson GW et al. Voluntary exposure of some western-hemisphere snake and lizard species to ultraviolet-B radiation in the field: how much ultraviolet-B should a lizard or snake receive in captivity? 2010 May-Jun Zoo Biol. pmid:19484753
Zhang YQ and Rao R Beyond ergosterol: linking pH to antifungal mechanisms. 2010 Nov-Dec Virulence pmid:21178501
Ahmad A et al. Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. 2011 Eur. J. Clin. Microbiol. Infect. Dis. pmid:20835742
Spitzer M et al. Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. 2011 Mol. Syst. Biol. pmid:21694716
Alvarez-Rueda N et al. Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. 2011 PLoS ONE pmid:21698128
Lee SY et al. Polyoxygenated ergostane-type sterols from the liquid culture of Ganoderma applanatum. 2011 Nat. Prod. Res. pmid:21678159
Carbajo V et al. Enhancement of late successional plants on ex-arable land by soil inoculations. 2011 PLoS ONE pmid:21760929
Perkowski J et al. Concentration of fungal biomass and trichothecenes in different parts of einkorn. 2011 Ann Agric Environ Med pmid:21736274
Liu J et al. Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalysed by Trypanosoma brucei sterol C-24-methyltransferase. 2011 Biochem. J. pmid:21736559
Kim H and Woloshuk CP Functional characterization of fst1 in Fusarium verticillioides during colonization of maize kernels. 2011 Mol. Plant Microbe Interact. pmid:20854112
Tsuyuki R et al. Enhancement of trichothecene production in Fusarium graminearum by cobalt chloride. 2011 J. Agric. Food Chem. pmid:21299216
Schmidtchen A et al. Membrane selectivity by W-tagging of antimicrobial peptides. 2011 Biochim. Biophys. Acta pmid:21192916
Skládanka J et al. Forage as a primary source of mycotoxins in animal diets. 2011 Int J Environ Res Public Health pmid:21318013
Parker JE et al. Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals. 2011 Appl. Environ. Microbiol. pmid:21169436
Foglia F et al. Small-angle neutron scattering studies of the effects of amphotericin B on phospholipid and phospholipid-sterol membrane structure. 2011 Biochim. Biophys. Acta pmid:21334304