| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Tinea | D014005 | 5 associated lipids |
| Mycoses | D009181 | 18 associated lipids |
Total
4
Ergosterol
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ergosterol?
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ergosterol
PubChem Associated disorders and diseases
What pathways are associated with Ergosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ergosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ergosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ergosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ergosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ergosterol?
Knock-out
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ergosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dick JD et al. | Incidence of polyene-resistant yeasts recovered from clinical specimens. | 1980 | Antimicrob. Agents Chemother. | pmid:7416742 |
| Kuchta T et al. | Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent. | 1995 | Antimicrob. Agents Chemother. | pmid:7492100 |
| Parker JE et al. | Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. | 2008 | Antimicrob. Agents Chemother. | pmid:18694951 |
| Mukhopadhyay K et al. | Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans. | 2004 | Antimicrob. Agents Chemother. | pmid:15105135 |
| Urbina JA et al. | Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi. | 1991 | Antimicrob. Agents Chemother. | pmid:2069379 |
| Burger-Kentischer A et al. | A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives. | 2011 | Antimicrob. Agents Chemother. | pmid:21746957 |
| Matsumoto M et al. | Strong antifungal activity of SS750, a new triazole derivative, is based on its selective binding affinity to cytochrome P450 of fungi. | 2002 | Antimicrob. Agents Chemother. | pmid:11796335 |
| MacPherson S et al. | Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. | 2005 | Antimicrob. Agents Chemother. | pmid:15855491 |
| Luna-Tapia A et al. | Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals. | 2015 | Antimicrob. Agents Chemother. | pmid:25666149 |
| Gamarra S et al. | Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans. | 2010 | Antimicrob. Agents Chemother. | pmid:20194694 |
| Hoehamer CF et al. | Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents. | 2010 | Antimicrob. Agents Chemother. | pmid:20145080 |
| Van den Bossche H et al. | In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. | 1980 | Antimicrob. Agents Chemother. | pmid:6250469 |
| Vannini GL et al. | Fungal toxicity of phosfon D and its reversion by lipids. | 1978 | Antimicrob. Agents Chemother. | pmid:666296 |
| Warrilow AG et al. | The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. | 2016 | Antimicrob. Agents Chemother. | pmid:27161631 |
| Kaneko Y et al. | Real-time microscopic observation of Candida biofilm development and effects due to micafungin and fluconazole. | 2013 | Antimicrob. Agents Chemother. | pmid:23459484 |
| Tatsumi Y et al. | Mechanism of action of efinaconazole, a novel triazole antifungal agent. | 2013 | Antimicrob. Agents Chemother. | pmid:23459486 |
| Whaley SG et al. | UPC2A is required for high-level azole antifungal resistance in Candida glabrata. | 2014 | Antimicrob. Agents Chemother. | pmid:24867980 |
| Arthington-Skaggs BA et al. | Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Candida isolates. | 2002 | Antimicrob. Agents Chemother. | pmid:12121921 |
| Ghelardi E et al. | Potential of Ergosterol synthesis inhibitors to cause resistance or cross-resistance in Trichophyton rubrum. | 2014 | Antimicrob. Agents Chemother. | pmid:24614379 |
| Eddouzi J et al. | Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. | 2013 | Antimicrob. Agents Chemother. | pmid:23629718 |
| Lafleur MD et al. | Potentiation of azole antifungals by 2-adamantanamine. | 2013 | Antimicrob. Agents Chemother. | pmid:23689724 |
| Hammond SM and Kliger BN | Mode of action of the polyene antibiotic candicidin: binding factors in the wall of Candida albicans. | 1976 | Antimicrob. Agents Chemother. | pmid:773298 |
| Onyewu C et al. | Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. | 2007 | Antimicrob. Agents Chemother. | pmid:17664323 |
| Vanden Bossche H et al. | The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. | 2004 | Antimicrob. Agents Chemother. | pmid:15328084 |
| Hsuchen CC and Feingold DS | Selective membrane toxicity of the polyene antibiotics: studies on natural membranes. | 1973 | Antimicrob. Agents Chemother. | pmid:4586145 |
| Onyewu C et al. | Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. | 2003 | Antimicrob. Agents Chemother. | pmid:12604527 |
| te Welscher YM et al. | Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. | 2010 | Antimicrob. Agents Chemother. | pmid:20385867 |
| Ramos H et al. | Enhanced action of amphotericin B on Leishmania mexicana resulting from heat transformation. | 1990 | Antimicrob. Agents Chemother. | pmid:2221868 |
| Lamb DC et al. | Stereoselective interaction of the azole antifungal agent SCH39304 with the cytochrome P-450 monooxygenase system isolated from Cryptococcus neoformans. | 1997 | Antimicrob. Agents Chemother. | pmid:9210667 |
| Thomas E et al. | Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans. | 2013 | Antimicrob. Agents Chemother. | pmid:23979757 |
| Yamaguchi H and Iwata K | Effect of fatty acyl group and sterol composition on sensitivity of lecithin liposomes to imidazole antimycotics. | 1979 | Antimicrob. Agents Chemother. | pmid:525988 |
| DeLucca AJ et al. | Fungicidal activity of cecropin A. | 1997 | Antimicrob. Agents Chemother. | pmid:9021214 |
| Ryder NS | Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. | 1985 | Antimicrob. Agents Chemother. | pmid:4039119 |
| Osborne CS et al. | Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. | 2006 | Antimicrob. Agents Chemother. | pmid:16723593 |
| Wheat J et al. | Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum. | 1997 | Antimicrob. Agents Chemother. | pmid:9021199 |
| Goldman RC et al. | Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors. | 1996 | Antimicrob. Agents Chemother. | pmid:8849227 |
| Mukhopadhyay K et al. | Drug susceptibilities of yeast cells are affected by membrane lipid composition. | 2002 | Antimicrob. Agents Chemother. | pmid:12435664 |
| Ghannoum MA et al. | Sterol composition of Cryptococcus neoformans in the presence and absence of fluconazole. | 1994 | Antimicrob. Agents Chemother. | pmid:7811014 |
| Sanglard D et al. | Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. | 2003 | Antimicrob. Agents Chemother. | pmid:12878497 |
| Young LY et al. | Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. | 2003 | Antimicrob. Agents Chemother. | pmid:12936965 |
| Benaim G et al. | Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy. | 2014 | Antimicrob. Agents Chemother. | pmid:24492373 |
| Georgopapadakou NH et al. | Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans. | 1987 | Antimicrob. Agents Chemother. | pmid:3551826 |
| Sokol-Anderson M et al. | Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B. | 1988 | Antimicrob. Agents Chemother. | pmid:3293525 |
| Siddiqui R et al. | Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity. | 2007 | Antimicrob. Agents Chemother. | pmid:17875991 |
| Beggs WH | Physicochemical cell damage in relation to lethal amphotericin B action. | 1994 | Antimicrob. Agents Chemother. | pmid:8192466 |
| Bammert GF and Fostel JM | Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. | 2000 | Antimicrob. Agents Chemother. | pmid:10770760 |
| Maldonado RA et al. | Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease. | 1993 | Antimicrob. Agents Chemother. | pmid:8328786 |
| Henry KW et al. | Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. | 2000 | Antimicrob. Agents Chemother. | pmid:10991846 |
| Fillinger S et al. | Genetic analysis of fenhexamid-resistant field isolates of the phytopathogenic fungus Botrytis cinerea. | 2008 | Antimicrob. Agents Chemother. | pmid:18779358 |
| Corrales M et al. | Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. | 2005 | Antimicrob. Agents Chemother. | pmid:15793138 |
| Vandeputte P et al. | A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. | 2008 | Antimicrob. Agents Chemother. | pmid:18694952 |
| Venkateswarlu K et al. | Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. | 1996 | Antimicrob. Agents Chemother. | pmid:8726005 |
| Bartlett MS et al. | Pneumocystis carinii is resistant to imidazole antifungal agents. | 1994 | Antimicrob. Agents Chemother. | pmid:7986021 |
| Vandeputte P et al. | Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. | 2009 | Antimicrob. Agents Chemother. | pmid:19380598 |
| Marr KA et al. | Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. | 1998 | Antimicrob. Agents Chemother. | pmid:9756759 |
| Orozco AS et al. | Mechanism of fluconazole resistance in Candida krusei. | 1998 | Antimicrob. Agents Chemother. | pmid:9756770 |
| Sud IJ and Feingold DS | Effect of ketoconazole on the fungicidal action of amphotericin B in Candida albicans. | 1983 | Antimicrob. Agents Chemother. | pmid:6299182 |
| Gruda I et al. | Structure-activity study of inhibition of amphotericin B (Fungizone) binding to sterols, toxicity to cells, and lethality to mice by esters of sucrose. | 1991 | Antimicrob. Agents Chemother. | pmid:2014979 |
| Hays PR et al. | Physiological effects of an antimycotic azasterol on cultures of Saccharomyces cerevisiae. | 1977 | Antimicrob. Agents Chemother. | pmid:332071 |
| Song JL et al. | The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs. | 2004 | Antimicrob. Agents Chemother. | pmid:15047513 |
| Dhamgaye S et al. | In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2. | 2012 | Antimicrob. Agents Chemother. | pmid:22006003 |
| Blosser SJ and Cramer RA | SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A). | 2012 | Antimicrob. Agents Chemother. | pmid:22006005 |
| vanden Bossche H et al. | Characterization of an azole-resistant Candida glabrata isolate. | 1992 | Antimicrob. Agents Chemother. | pmid:1482129 |
| Fang Y et al. | A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis. | 2012 | Antimicrob. Agents Chemother. | pmid:22252817 |
| Chmel' IaV et al. | [Screening of natural compounds with hypolipidemic activity]. | 2004 | Antibiot. Khimioter. | pmid:15727139 |
| Baranova NA et al. | [Micromycetes metabolites--inhibitors of growth and sterol biosynthesis in yeasts]. | 2002 | Antibiot. Khimioter. | pmid:12077938 |
| Avtonomova AV et al. | [Submerged cultivation and chemical composition of Hericium erinaceus mycelium]. | 2012 | Antibiot. Khimioter. | pmid:23350189 |
| Baranova NA et al. | [The growth of Rhodotorula rubra yeasts and their synthesis of ergosterol on media with lovastatin]. | 1996 | Antibiot. Khimioter. | pmid:9214284 |
| KreÄner VG et al. | [The effect of lovastatin on sterol synthesis and yeast resistance to polyene antibiotics]. | 1993 Oct-Nov | Antibiot. Khimioter. | pmid:8085886 |
| Navashin PS | [Antifungal chemotherapy. Progress and problems]. | 1998 | Antibiot. Khimioter. | pmid:9777098 |
| Bibikova MV et al. | [Lovastatin effect on ergosterol production and growth of Tolypocladium inflatum 106]. | 2004 | Antibiot. Khimioter. | pmid:15460015 |
| Medoff G et al. | Antifungal agents useful in therapy of systemic fungal infections. | 1983 | Annu. Rev. Pharmacol. Toxicol. | pmid:6307124 |
| Parks LW and Casey WM | Physiological implications of sterol biosynthesis in yeast. | 1995 | Annu. Rev. Microbiol. | pmid:8561481 |
| Cooper AB et al. | Synthesis and antifungal properties of 14-aminomethyl-substituted lanosterol derivatives. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3214062 |
| Shin KH et al. | Antioxidant and immunostimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp. | 2001 | Ann. N. Y. Acad. Sci. | pmid:11795517 |
| Holz RW | The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes. | 1974 | Ann. N. Y. Acad. Sci. | pmid:4528030 |
| Vanden Bossche H et al. | Mode of action studies. Basis for the search of new antifungal drugs. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2850749 |
| Ryder NS | Mechanism of action and biochemical selectivity of allylamine antimycotic agents. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3063168 |
| Juliano RL et al. | Selective toxicity and enhanced therapeutic index of liposomal polyene antibiotics in systemic fungal infections. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3860162 |
| Mpona-Minga M et al. | [Effect of a subinhibitory dose of amphotericin B on cellular fatty acid and sterol composition of Candida albicans]. | 1988 Sep-Oct | Ann. Inst. Pasteur Microbiol. | pmid:3075500 |
| Regerat F et al. | [Investigation on ergosterol occurence in fruit bodies of some macromycetes]. | 1976 May-Jun | Ann Pharm Fr | pmid:999160 |
| Regerat F et al. | [Presence of ergosterol and portensterol in mycelial cultures of Tricholoma portentosum and Rhodopaxillus nudus]. | 1976 Sep-Oct | Ann Pharm Fr | pmid:1035071 |
| Szponar B and Larsson L | Use of mass spectrometry for characterising microbial communities in bioaerosols. | 2001 | Ann Agric Environ Med | pmid:11748866 |
| Szwajkowska-Michalek L et al. | Contents of microscopic fungi in dusts coming from cereal analysis laboratories. | 2010 | Ann Agric Environ Med | pmid:20684486 |
| Stuper-Szablewska K and Perkowski J | Contamination of wheat grain with microscopic fungi and their metabolites in Poland in 2006-2009. | 2014 | Ann Agric Environ Med | pmid:25292118 |
| Perkowski J et al. | Concentration of fungal biomass and trichothecenes in different parts of einkorn. | 2011 | Ann Agric Environ Med | pmid:21736274 |
| Perkowski J et al. | The effect of environmental conditions on ergosterol and trichothecene content of naturally contaminated oat grain. | 2008 | Ann Agric Environ Med | pmid:19061262 |
| Piecková E and Jesenská Z | Microscopic fungi in dwellings and their health implications in humans. | 1999 | Ann Agric Environ Med | pmid:10384209 |
| Stuper-Szablewska K and Perkowski J | Level of contamination with mycobiota and contents of mycotoxins from the group of trichothecenes in grain of wheat , oats, barley, rye and triticale harvested in Poland in 2006- 2008. | 2017 | Ann Agric Environ Med | pmid:28378974 |
| Mohan R et al. | Withaferin A is a potent inhibitor of angiogenesis. | 2004 | Angiogenesis | pmid:15516832 |
| Sashidhar RB et al. | Enhanced fluorescence of ergosterol by iodination and determination of ergosterol by fluorodensitometry. | 1988 | Analyst | pmid:3414969 |
| Parkinson DR et al. | Analysis of ergosterol for the detection of mold in soils by automated on-fiber derivatization headspace extraction-SPME-GC/MS. | 2010 | Anal. Chim. Acta | pmid:20113733 |
| Mermet-Bouvier R | Analysis of the photochemical isomers of ergosterol by column chromatography. | 1973 | Anal. Chem. | pmid:4357647 |
| Wiltschi B et al. | Sterol binding assay using surface plasmon fluorescence spectroscopy. | 2006 | Anal. Chem. | pmid:16408938 |
| Hagerman RA et al. | Solid-phase extraction of lipid from Saccharomyces cerevisiae followed by high-performance liquid chromatography analysis of coenzyme Q content. | 2001 | Anal. Biochem. | pmid:11520043 |
| Olsher M and Chong PL | Sterol superlattice affects antioxidant potency and can be used to assess adverse effects of antioxidants. | 2008 | Anal. Biochem. | pmid:18694720 |
| Toh TH et al. | Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry. | 2001 | Anal. Biochem. | pmid:11141305 |
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
| Liu X et al. | Characterization of ganoderma spore lipid by stable carbon isotope analysis: implications for authentication. | 2007 | Anal Bioanal Chem | pmid:17447054 |
| Dohnal V et al. | Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process. | 2010 | Anal Bioanal Chem | pmid:20225055 |