| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Tinea | D014005 | 5 associated lipids |
| Mycoses | D009181 | 18 associated lipids |
Total
4
Ergosterol
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ergosterol?
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ergosterol
PubChem Associated disorders and diseases
What pathways are associated with Ergosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ergosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ergosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ergosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ergosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ergosterol?
Knock-out
Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ergosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu QP et al. | Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance. | 2012 | PLoS ONE | pmid:22952996 |
| Bui DC et al. | The FgNot3 Subunit of the Ccr4-Not Complex Regulates Vegetative Growth, Sporulation, and Virulence in Fusarium graminearum. | 2016 | PLoS ONE | pmid:26799401 |
| Gutiérrez MS et al. | Molecular Characterization and Functional Analysis of Cytochrome b5 Reductase (CBR) Encoding Genes from the Carotenogenic Yeast Xanthophyllomyces dendrorhous. | 2015 | PLoS ONE | pmid:26466337 |
| Kodedová M and Sychrová H | Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae. | 2015 | PLoS ONE | pmid:26418026 |
| Ano Y et al. | Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum. | 2015 | PLoS ONE | pmid:25760331 |
| Tao X et al. | A novel strategy to construct yeast Saccharomyces cerevisiae strains for very high gravity fermentation. | 2012 | PLoS ONE | pmid:22363590 |
| Filipiak M and Weiner J | How to make a beetle out of wood: multi-elemental stoichiometry of wood decay, xylophagy and fungivory. | 2014 | PLoS ONE | pmid:25536334 |
| Lieu MH et al. | Mechanisms underlying stage-1 TRPL channel translocation in Drosophila photoreceptors. | 2012 | PLoS ONE | pmid:22363689 |
| Zhao YY et al. | A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS. | 2014 | PLoS ONE | pmid:25535749 |
| Chen YL et al. | Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. | 2013 | PLoS ONE | pmid:23472097 |
| Brumfield KM et al. | Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. | 2010 | PLoS ONE | pmid:20084111 |
| Ma B et al. | Interference and Mechanism of Dill Seed Essential Oil and Contribution of Carvone and Limonene in Preventing Sclerotinia Rot of Rapeseed. | 2015 | PLoS ONE | pmid:26133771 |
| Wang Y et al. | Investigating migration inhibition and apoptotic effects of Fomitopsis pinicola chloroform extract on human colorectal cancer SW-480 cells. | 2014 | PLoS ONE | pmid:24992193 |
| Alvarez-Rueda N et al. | Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. | 2011 | PLoS ONE | pmid:21698128 |
| Campos-Bermudez VA et al. | Transcriptional and metabolic changes associated to the infection by Fusarium verticillioides in maize inbreds with contrasting ear rot resistance. | 2013 | PLoS ONE | pmid:23637860 |
| Iwaki A et al. | Vanillin inhibits translation and induces messenger ribonucleoprotein (mRNP) granule formation in saccharomyces cerevisiae: application and validation of high-content, image-based profiling. | 2013 | PLoS ONE | pmid:23637899 |
| Carbajo V et al. | Enhancement of late successional plants on ex-arable land by soil inoculations. | 2011 | PLoS ONE | pmid:21760929 |
| Tesnière C et al. | Impact of nutrient imbalance on wine alcoholic fermentations: nitrogen excess enhances yeast cell death in lipid-limited must. | 2013 | PLoS ONE | pmid:23658613 |
| Pacheco A et al. | C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. | 2013 | PLoS ONE | pmid:24040213 |
| Cantu D et al. | Next generation sequencing provides rapid access to the genome of Puccinia striiformis f. sp. tritici, the causal agent of wheat stripe rust. | 2011 | PLoS ONE | pmid:21909385 |
| Crabbé A et al. | Spaceflight enhances cell aggregation and random budding in Candida albicans. | 2013 | PLoS ONE | pmid:24324620 |
| Takami T et al. | A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. | 2012 | PLoS ONE | pmid:23145048 |
| Verma S et al. | CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani. | 2011 | PLoS ONE | pmid:21966477 |
| Tian J et al. | The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus. | 2012 | PLoS ONE | pmid:22272289 |
| Kamthan A et al. | Expression of C-5 sterol desaturase from an edible mushroom in fisson yeast enhances its ethanol and thermotolerance. | 2017 | PLoS ONE | pmid:28278249 |
| Deak E et al. | Aspergillus terreus accessory conidia are unique in surface architecture, cell wall composition and germination kinetics. | 2009 | PLoS ONE | pmid:19888344 |
| DuBois JC and Smulian AG | Sterol Regulatory Element Binding Protein (Srb1) Is Required for Hypoxic Adaptation and Virulence in the Dimorphic Fungus Histoplasma capsulatum. | 2016 | PLoS ONE | pmid:27711233 |
| Choi JN et al. | Influence of iron regulation on the metabolome of Cryptococcus neoformans. | 2012 | PLoS ONE | pmid:22911836 |
| Zhang YQ et al. | Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. | 2010 | PLoS Pathog. | pmid:20532216 |
| Xu W et al. | Sterol biosynthesis is required for heat resistance but not extracellular survival in leishmania. | 2014 | PLoS Pathog. | pmid:25340392 |
| Rydengård V et al. | Histidine-rich glycoprotein protects from systemic Candida infection. | 2008 | PLoS Pathog. | pmid:18797515 |
| Koziróg A et al. | Influence of N,N-bis(3-aminopropyl)dodecylamine on the mycelium growth and the cell wall composition of resistance and sensitive strains belonging to the genus Aspergillus. | 2005 | Pol. J. Microbiol. | pmid:16599297 |
| Zimowski JJ | [Metabolites of vitamin D and their biological function (author's transl)]. | 1976 | Postepy Biochem. | pmid:129768 |
| Szablewski T et al. | Ergosterol as an indicator of the presence of microscopic fungi in eggs for human consumption produced in different husbandry systems. | 2010 | Poult. Sci. | pmid:20952713 |
| Linck LM et al. | Fetal demise with Smith-Lemli-Opitz syndrome confirmed by tissue sterol analysis and the absence of measurable 7-dehydrocholesterol Delta(7)-reductase activity in chorionic villi. | 2000 | Prenat. Diagn. | pmid:10719329 |
| Dikanskaia EM and Robysheva ZN | [Formation of ergosterol by yeasts of Candida genus]. | 1975 Jan-Feb | Prikl. Biokhim. Mikrobiol. | pmid:1168902 |
| MikhaÄlova NP et al. | [Sterol level in Saccharomyces cerevisiae mutants with altered ergosterol biosynthesis]. | 1990 May-Jun | Prikl. Biokhim. Mikrobiol. | pmid:2202986 |
| Klimashina MM et al. | [Analysis of the products of ergosta-7,22-dien-3-beta-ol biotransformation by a Nocardia erythropolis culture]. | 1988 Sep-Oct | Prikl. Biokhim. Mikrobiol. | pmid:3072561 |
| Govseeva NN | [The effect of lumisterol-3 on intestinal calcium absorption and the calcification of osseous tissue]. | 1974 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:4375282 |
| MikhaÄlova NP et al. | [Evaluation of the vitamin D activity of yeasts with altered sterol metabolism]. | 1988 Jan-Feb | Prikl. Biokhim. Mikrobiol. | pmid:3285341 |
| Sinitskaia NA et al. | [Microbiological synthesis of sterols]. | 1993 Sep-Oct | Prikl. Biokhim. Mikrobiol. | pmid:8234220 |
| FREEMAN S et al. | Toxic manifestations following large doses of ertron. | 1945 | Proc Annu Meet Cent Soc Clin Res U S | pmid:21021601 |
| MartÃn J and López P | Vitamin D supplementation increases the attractiveness of males' scent for female Iberian rock lizards. | 2006 | Proc. Biol. Sci. | pmid:17002947 |
| McConnell H and Radhakrishnan A | Theory of the deuterium NMR of sterol-phospholipid membranes. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16432189 |
| te Welscher YM et al. | Polyene antibiotic that inhibits membrane transport proteins. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22733749 |
| Aguilar PS et al. | Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20150508 |
| Fraser HB et al. | Evidence for widespread adaptive evolution of gene expression in budding yeast. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133628 |
| Becker JM et al. | Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21135205 |
| Palacios DS et al. | Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21368185 |
| Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106303 |
| Dahl C et al. | A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterol. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2438691 |
| South PF et al. | H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23382196 |
| Kořený L et al. | Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22355128 |
| Chong PL | Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937839 |
| Kawasaki S et al. | Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3898069 |
| Ramgopal M and Bloch K | Sterol synergism in yeast. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6338497 |
| Bagnat M et al. | Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10716729 |
| Proszynski TJ et al. | A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16330752 |
| Gray KC et al. | Amphotericin primarily kills yeast by simply binding ergosterol. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22308411 |
| Brennan PJ et al. | The lipids of fungi. | 1974 | Prog Chem Fats Other Lipids | pmid:4610639 |
| Schroeder F | Fluorescent sterols: probe molecules of membrane structure and function. | 1984 | Prog. Lipid Res. | pmid:6387716 |
| Boissy G et al. | The 2.1 A structure of an elicitin-ergosterol complex: a recent addition to the Sterol Carrier Protein family. | 1999 | Protein Sci. | pmid:10386869 |
| Sumathi JC et al. | Molecular evidence of fungal signatures in the marine protist Corallochytrium limacisporum and its implications in the evolution of animals and fungi. | 2006 | Protist | pmid:16899404 |
| Trinci AP and Collinge AJ | Occlusion of the septal pores of damaged hyphae of Neurospora crassa by hexagonal crystals. | 1974 | Protoplasma | pmid:4275239 |
| Leefmann T et al. | Spectral characterization of ten cyclic lipids using time-of-flight secondary ion mass spectrometry. | 2013 | Rapid Commun. Mass Spectrom. | pmid:23413216 |
| Kontro MH and Vauramo S | Silylation can be omitted in gas-liquid chromatographic/mass spectrometric analysis of ergosterol. | 2009 | Rapid Commun. Mass Spectrom. | pmid:19191255 |
| Huang L et al. | Identification of beta-sitosterol, stigmasterol and ergosterin in A. roxburghii using supercritical fluid extraction followed by liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17705339 |
| Duschak VG and Couto AS | An insight on targets and patented drugs for chemotherapy of Chagas disease. | 2007 | Recent Pat Antiinfect Drug Discov | pmid:18221162 |
| Zanatta L et al. | Regulation of aromatase expression by 1α,25(OH)2 vitamin D3 in rat testicular cells. | 2011 | Reprod. Fertil. Dev. | pmid:21635821 |
| Khan A et al. | Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. | 2010 | Res. Microbiol. | pmid:20868749 |
| Bahmed K et al. | Relation between cell wall chitin content and susceptibility to amphotericin B in Kluyveromyces, Candida and Schizosaccharomyces species. | 2003 | Res. Microbiol. | pmid:12706511 |
| Liu JY et al. | Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. | 2015 | Res. Microbiol. | pmid:25748216 |
| Andrade-Pavón D et al. | The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: a proposal as a therapeutic target and as a study model. | 2014 Jan-Mar | Rev Iberoam Micol | pmid:24270073 |
| Gomez-Lopez A et al. | In vitro antifungal susceptibility pattern and ergosterol content in clinical yeast strains. | 2011 Apr-Jun | Rev Iberoam Micol | pmid:21251996 |
| Cabral ME et al. | Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification. | 2013 | Rev Iberoam Micol | pmid:23069981 |
| Belaunzarán ML | [Chagas disease: Globalization and new hope for its cure]. | 2015 Apr-Jun | Rev. Argent. Microbiol. | pmid:26028584 |
| Feitosa AO et al. | Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | 2016 Jul - Sep | Rev. Argent. Microbiol. | pmid:27567521 |
| Ryley JF et al. | Azole resistance in Candida albicans. | 1984 | Sabouraudia | pmid:6322363 |
| Voigt WH | On the mode of action of antimycotics, especially of clotrimazole (Canesten), on the ultrastructural level of human pathogenic fungi. | 1978 | Scand J Infect Dis Suppl | pmid:285460 |
| Bojsen R et al. | A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations. | 2016 | Sci Rep | pmid:26903175 |
| Sugiura S and Mima J | Physiological lipid composition is vital for homotypic ER membrane fusion mediated by the dynamin-related GTPase Sey1p. | 2016 | Sci Rep | pmid:26838333 |
| Zielińska J et al. | Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail. | 2016 | Sci Rep | pmid:26742886 |
| Foglia F et al. | Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes. | 2012 | Sci Rep | pmid:23110248 |
| Markowicz P et al. | A study on particles and some microbial markers in waterpipe tobacco smoke. | 2014 | Sci. Total Environ. | pmid:25181042 |
| Szponar B et al. | Bacterial and fungal markers in tobacco smoke. | 2012 | Sci. Total Environ. | pmid:23026151 |
| Zhang X et al. | A longitudinal study of sick building syndrome among pupils in relation to microbial components in dust in schools in China. | 2011 | Sci. Total Environ. | pmid:21943723 |
| Martins CC et al. | Multi-molecular markers and metals as tracers of organic matter inputs and contamination status from an Environmental Protection Area in the SW Atlantic (Laranjeiras Bay, Brazil). | 2012 | Sci. Total Environ. | pmid:22244354 |
| Berriman M et al. | The genome of the African trypanosome Trypanosoma brucei. | 2005 | Science | pmid:16020726 |
| Ferber D | Infectious disease. New weapons in the battle of the bugs. | 2002 | Science | pmid:11799221 |
| Suzuki G et al. | A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress. | 2012 | Science | pmid:22517861 |
| SAVARD K and GRANT GA | Ergosterol from the mycelium of Penicillium notatum (submerged culture). | 1946 | Science | pmid:21002755 |
| Selmecki A et al. | Aneuploidy and isochromosome formation in drug-resistant Candida albicans. | 2006 | Science | pmid:16857942 |
| Clemmensen KE et al. | Roots and associated fungi drive long-term carbon sequestration in boreal forest. | 2013 | Science | pmid:23539604 |
| Heitman J | Cell biology. A fungal Achilles' heel. | 2005 | Science | pmid:16195450 |
| Cowen LE and Lindquist S | Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. | 2005 | Science | pmid:16195452 |
| Caspeta L et al. | Biofuels. Altered sterol composition renders yeast thermotolerant. | 2014 | Science | pmid:25278608 |
| Cheng C and Kao KC | Microbiology. How to survive being hot and inebriated. | 2014 | Science | pmid:25278598 |
| Yang H et al. | Sterol esterification in yeast: a two-gene process. | 1996 | Science | pmid:8650549 |
| Holick MF et al. | Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. | 1981 | Science | pmid:6256855 |
| MacLaughlin JA et al. | Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. | 1982 | Science | pmid:6281884 |