MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mukherjee S et al. | Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. | 1998 | Biophys. J. | pmid:9746532 |
De Lucca AJ et al. | Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1. | 1998 | Can. J. Microbiol. | pmid:9734302 |
Fournier I et al. | The structuring effects of amphotericin B on pure and ergosterol- or cholesterol-containing dipalmitoylphosphatidylcholine bilayers: a differential scanning calorimetry study. | 1998 | Biochim. Biophys. Acta | pmid:9733926 |
Urbina JA et al. | A carbon-13 nuclear magnetic resonance spectroscopic study of inter-proton pair order parameters: a new approach to study order and dynamics in phospholipid membrane systems. | 1998 | Biophys. J. | pmid:9726938 |
Crowley JH et al. | A calcium-dependent ergosterol mutant of Saccharomyces cerevisiae. | 1998 | Curr. Genet. | pmid:9724410 |
Wang MM et al. | Role of the sterol superlattice in the partitioning of the antifungal drug nystatin into lipid membranes. | 1998 | Biochemistry | pmid:9718302 |
Launhardt H et al. | Drug-induced phenotypes provide a tool for the functional analysis of yeast genes. | 1998 | Yeast | pmid:9717239 |
Tejada-Simon MV and Pestka JJ | Production of polyclonal antibody against ergosterol hemisuccinate using Freund's and Titermax adjuvants. | 1998 | J. Food Prot. | pmid:9713773 |
Vazquez JA et al. | Stable phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azoles. | 1998 | J. Clin. Microbiol. | pmid:9705415 |
Atta-ur-Rahman A et al. | Two new ergostane-type steroidal lactones from Withania coagulans. | 1998 | J. Nat. Prod. | pmid:9644072 |