MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of Ergosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ergosterol is suspected in Infection, Mycoses, Candidiasis, Chagas Disease, Cyst, Dermatophytosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ergosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Leishmaniasis | D007896 | 19 associated lipids |
Tinea | D014005 | 5 associated lipids |
Mycoses | D009181 | 18 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Ergosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.' (Pasrija R et al., 2008) and Knock-out are used in the study 'UPC2A is required for high-level azole antifungal resistance in Candida glabrata.' (Whaley SG et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhuang Z et al. | The Master Transcription Factor mtfA Governs Aflatoxin Production, Morphological Development and Pathogenicity in the Fungus Aspergillus flavus. | 2016 | Toxins (Basel) | pmid:26805883 |
Song J et al. | The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. | 2016 | MBio | pmid:26908577 |
Bojsen R et al. | A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations. | 2016 | Sci Rep | pmid:26903175 |
Han B et al. | Antifungal activity of Rubus chingii extract combined with fluconazole against fluconazole-resistant Candida albicans. | 2016 | Microbiol. Immunol. | pmid:26891940 |
Sugiura S and Mima J | Physiological lipid composition is vital for homotypic ER membrane fusion mediated by the dynamin-related GTPase Sey1p. | 2016 | Sci Rep | pmid:26838333 |
Bui DC et al. | The FgNot3 Subunit of the Ccr4-Not Complex Regulates Vegetative Growth, Sporulation, and Virulence in Fusarium graminearum. | 2016 | PLoS ONE | pmid:26799401 |
Zielińska J et al. | Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail. | 2016 | Sci Rep | pmid:26742886 |
Song XS et al. | An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. | 2016 | New Phytol. | pmid:26720747 |
Nakagawa Y et al. | The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores. | 2016 | Biochemistry | pmid:27227740 |
Nóbrega RO et al. | Investigation of the antifungal activity of carvacrol against strains of Cryptococcus neoformans. | 2016 | Pharm Biol | pmid:27225838 |