| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hargrove TY et al. | Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. | 2016 | J. Lipid Res. | pmid:27313059 |
| Herchi W et al. | Phytosterols accumulation in the seeds of Linum usitatissimum L. | 2009 | Plant Physiol. Biochem. | pmid:19616960 |
| Kim HB et al. | Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity. | 2005 | Plant Physiol. | pmid:16040657 |
| O'Brien M et al. | Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity. | 2005 | Plant Physiol. | pmid:16169959 |
| Lepesheva GI et al. | CYP51 from Trypanosoma brucei is obtusifoliol-specific. | 2004 | Biochemistry | pmid:15311940 |
| Kushiro M et al. | Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11437378 |
| Lamb DC et al. | Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans. | 1998 | FEBS Lett. | pmid:9559662 |
| Cabello-Hurtado F et al. | Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14alpha-demethylase (CYP51) in wheat. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9016788 |
| Kahn RA et al. | Isolation and reconstitution of the heme-thiolate protein obtusifoliol 14alpha-demethylase from Sorghum bicolor (L.) Moench. | 1996 | J. Biol. Chem. | pmid:8955137 |
| Grausem B et al. | Functional expression of Saccharomyces cerevisiae CYP51A1 encoding lanosterol-14-demethylase in tobacco results in bypass of endogenous sterol biosynthetic pathway and resistance to an obtusifoliol-14-demethylase herbicide inhibitor. | 1995 | Plant J. | pmid:7773307 |
Obtusifoliol
Obtusifoliol is a lipid of Sterol Lipids (ST) class. Obtusifoliol is associated with abnormalities such as abnormal fragmented structure and Hereditary Diseases. The involved functions are known as Anabolism, Process, Gas retention, physiological aspects and enzyme biosynthesis. Obtusifoliol often locates in Microsomes, Tissue membrane, microsomal membrane, Clone and Body tissue. The associated genes with Obtusifoliol are MBD2 gene, GTF2I gene, PFDN5 gene, CYP51A1 gene and Gene Family. The related lipids are obtusifoliol, Sterols, Micelles, campesterol and ebericol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Obtusifoliol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Obtusifoliol?
Obtusifoliol is suspected in Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Obtusifoliol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Obtusifoliol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Obtusifoliol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Obtusifoliol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Obtusifoliol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Obtusifoliol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Obtusifoliol?
Knock-out
Knock-out are used in the study 'Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity.' (Kim HB et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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