| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kushiro M et al. | Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11437378 |
| Lepesheva GI et al. | CYP51 from Trypanosoma brucei is obtusifoliol-specific. | 2004 | Biochemistry | pmid:15311940 |
| Aoyama Y and Yoshida Y | The 4 beta-methyl group of substrate does not affect the activity of lanosterol 14 alpha-demethylase (P-450(14)DM) of yeast: difference between the substrate recognition by yeast and plant sterol 14 alpha-demethylases. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1567403 |
| Rahier A and Taton M | Plant sterol biosynthesis: 7-oxo-obtusifoliol analogues as potential selective inhibitors of cytochrome P-450 dependent obtusifoliol 14 alpha-demethylase. | 1992 | Biochim. Biophys. Acta | pmid:1571366 |
| Kim HB et al. | Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity. | 2005 | Plant Physiol. | pmid:16040657 |
| O'Brien M et al. | Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity. | 2005 | Plant Physiol. | pmid:16169959 |
| Taton M and Rahier A | Properties and structural requirements for substrate specificity of cytochrome P-450-dependent obtusifoliol 14 alpha-demethylase from maize (Zea mays) seedlings. | 1991 | Biochem. J. | pmid:1859375 |
| Herchi W et al. | Phytosterols accumulation in the seeds of Linum usitatissimum L. | 2009 | Plant Physiol. Biochem. | pmid:19616960 |
| Hargrove TY et al. | Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. | 2016 | J. Lipid Res. | pmid:27313059 |
Obtusifoliol
Obtusifoliol is a lipid of Sterol Lipids (ST) class. Obtusifoliol is associated with abnormalities such as abnormal fragmented structure and Hereditary Diseases. The involved functions are known as Anabolism, Process, Gas retention, physiological aspects and enzyme biosynthesis. Obtusifoliol often locates in Microsomes, Tissue membrane, microsomal membrane, Clone and Body tissue. The associated genes with Obtusifoliol are MBD2 gene, GTF2I gene, PFDN5 gene, CYP51A1 gene and Gene Family. The related lipids are obtusifoliol, Sterols, Micelles, campesterol and ebericol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Obtusifoliol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Obtusifoliol?
Obtusifoliol is suspected in Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Obtusifoliol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Obtusifoliol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Obtusifoliol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Obtusifoliol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Obtusifoliol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Obtusifoliol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Obtusifoliol?
Knock-out
Knock-out are used in the study 'Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity.' (Kim HB et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.