lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Demarne Y et al. | Effects of two different medium-chain triglycerides (tri C8:O and tri C12:O) on liver lipids in the growing rat. | 1978 | Arch. Int. Physiol. Biochim. | pmid:80984 |
Que Hee SS and Zainal H | Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves. | 2010 | Arch. Environ. Contam. Toxicol. | pmid:19855916 |
Stodtmeister W et al. | [Fatty acid composition of lipids from the hair in psoriasis vulgaris (author's transl)]. | 1979 | Arch. Dermatol. Res. | pmid:464651 |
Honoré B et al. | Cobinding of bilirubin and laurate to human serum albumin: spectroscopic characterization of stoichiometric complexes. | 1988 | Arch. Biochem. Biophys. | pmid:3178221 |
Shet Ms et al. | The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. | 1996 | Arch. Biochem. Biophys. | pmid:8651697 |
Lewis DF | Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | 2003 | Arch. Biochem. Biophys. | pmid:12464242 |
Puchkaev AV et al. | Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. | 2003 | Arch. Biochem. Biophys. | pmid:12464244 |
Salaün JP et al. | Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. | 1988 | Arch. Biochem. Biophys. | pmid:3341756 |
Finlayson MJ et al. | Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. | 1987 | Arch. Biochem. Biophys. | pmid:3492962 |
Kahn RA et al. | A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. | 2001 | Arch. Biochem. Biophys. | pmid:11437349 |
Capdevila J et al. | Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. | 1985 | Arch. Biochem. Biophys. | pmid:3933431 |
Norman HA and Thompson GA | Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. | 1985 | Arch. Biochem. Biophys. | pmid:4051499 |
Powell PK et al. | Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8914854 |
Lu P et al. | Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. | 1997 | Arch. Biochem. Biophys. | pmid:8990261 |
Girvan HM et al. | Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. | 2011 | Arch. Biochem. Biophys. | pmid:20868649 |
Cowart LA et al. | Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. | 2001 | Arch. Biochem. Biophys. | pmid:11368173 |
Duncan T et al. | A glycoprotein binding retinoids and fatty acids is present in Drosophila. | 1994 | Arch. Biochem. Biophys. | pmid:8031123 |
Gilep AA et al. | Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments. | 2001 | Arch. Biochem. Biophys. | pmid:11396924 |
Puchkaev AV and Ortiz de Montellano PR | The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. | 2005 | Arch. Biochem. Biophys. | pmid:15629120 |
Straub P et al. | Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. | 1993 | Arch. Biochem. Biophys. | pmid:8215458 |