lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Albuminuria D000419 18 associated lipids
Bird Diseases D001715 4 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Cerebral Infarction D002544 6 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Hemolysis D006461 131 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nephrosis, Lipoid D009402 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Demarne Y et al. Effects of two different medium-chain triglycerides (tri C8:O and tri C12:O) on liver lipids in the growing rat. 1978 Arch. Int. Physiol. Biochim. pmid:80984
Que Hee SS and Zainal H Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves. 2010 Arch. Environ. Contam. Toxicol. pmid:19855916
Stodtmeister W et al. [Fatty acid composition of lipids from the hair in psoriasis vulgaris (author's transl)]. 1979 Arch. Dermatol. Res. pmid:464651
Honoré B et al. Cobinding of bilirubin and laurate to human serum albumin: spectroscopic characterization of stoichiometric complexes. 1988 Arch. Biochem. Biophys. pmid:3178221
Shet Ms et al. The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. 1996 Arch. Biochem. Biophys. pmid:8651697
Lewis DF Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. 2003 Arch. Biochem. Biophys. pmid:12464242
Puchkaev AV et al. Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. 2003 Arch. Biochem. Biophys. pmid:12464244
Salaün JP et al. Differential inactivation of plant lauric acid omega- and in-chain-hydroxylases by terminally unsaturated fatty acids. 1988 Arch. Biochem. Biophys. pmid:3341756
Finlayson MJ et al. Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. 1987 Arch. Biochem. Biophys. pmid:3492962
Kahn RA et al. A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. 2001 Arch. Biochem. Biophys. pmid:11437349
Capdevila J et al. Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. 1985 Arch. Biochem. Biophys. pmid:3933431
Norman HA and Thompson GA Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. 1985 Arch. Biochem. Biophys. pmid:4051499
Powell PK et al. Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8914854
Lu P et al. Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. 1997 Arch. Biochem. Biophys. pmid:8990261
Girvan HM et al. Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. 2011 Arch. Biochem. Biophys. pmid:20868649
Cowart LA et al. Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. 2001 Arch. Biochem. Biophys. pmid:11368173
Duncan T et al. A glycoprotein binding retinoids and fatty acids is present in Drosophila. 1994 Arch. Biochem. Biophys. pmid:8031123
Gilep AA et al. Reconstitution of the enzymatic activities of cytochrome P450s using recombinant flavocytochromes containing rat cytochrome b(5) fused to NADPH--cytochrome P450 reductase with various membrane-binding segments. 2001 Arch. Biochem. Biophys. pmid:11396924
Puchkaev AV and Ortiz de Montellano PR The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. 2005 Arch. Biochem. Biophys. pmid:15629120
Straub P et al. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity. 1993 Arch. Biochem. Biophys. pmid:8215458