lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Mohan S and Raetz CR Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate. 1994 J. Bacteriol. pmid:7961456
Lee CK et al. Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system. 1994 Biol. Pharm. Bull. pmid:7874070
Preobrazhenskaia TA et al. [Comparative effect of polymyxin B on lipid bilayer membranes with different lipid composition]. 1994 Nov-Dec Biofizika pmid:7873621
Clarke SE et al. Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. 1994 Nov-Dec Chem. Res. Toxicol. pmid:7696540
Motoyama Y et al. Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on a peripheral arterial occlusive disease model in rats. 1995 Prostaglandins pmid:7652186
Smith SW and Anderson BD Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions. 1995 J Pharm Sci pmid:7658343
Kromhout D et al. Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. 1995 Prev Med pmid:7644455
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Pronczuk A et al. Plasma lipids are affected similarly by dietary lauric or palmitic acid in gerbils and monkeys. 1995 Lipids pmid:8614307
Amet Y et al. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. 1995 Biochem. Pharmacol. pmid:8615855
Saito M et al. 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum. 1995 J. Chromatogr. B, Biomed. Appl. pmid:8788145
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Lee SK et al. Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. 1995 Pancreas pmid:7479681
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Redondo O et al. Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. 1995 Biochim. Biophys. Acta pmid:7827103
Ramarao MK et al. Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1. 1995 J. Biol. Chem. pmid:7829524
Hermansen JE Prediction of milk fatty acid profile in dairy cows fed dietary fat differing in fatty acid composition. 1995 J. Dairy Sci. pmid:7790578
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Godet MC et al. Inclusion/exclusion of fatty acids in amylose complexes as a function of the fatty acid chain length. 1995 Int. J. Biol. Macromol. pmid:8789347
Geissdörfer W et al. Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1. 1995 Microbiology (Reading, Engl.) pmid:7670642
Chaurasia CS et al. Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. 1995 Arch. Biochem. Biophys. pmid:7872779
Schwab US et al. Lauric and palmitic acid-enriched diets have minimal impact on serum lipid and lipoprotein concentrations and glucose metabolism in healthy young women. 1995 J. Nutr. pmid:7876922
Lee CK et al. Transdermal delivery of theophylline using an ethanol/panasate 800-ethylcellulose gel preparation. 1995 Biol. Pharm. Bull. pmid:7735237
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Constantinides PP et al. Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. 1996 Pharm. Res. pmid:8932438
Kemp PM et al. Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency. 1996 Am J Forensic Med Pathol pmid:8838477
Murataliev MB and Feyereisen R Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. 1996 Biochemistry pmid:8942669
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Hiratsuka M et al. Sex differences in constitutive level of renal lauric acid hydroxylase activities and CYP4A-related proteins in mice. 1996 Biol. Pharm. Bull. pmid:8860949
Wang MH et al. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. 1996 Arch. Biochem. Biophys. pmid:8954571
Charbon V et al. Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs. 1996 Pharm. Res. pmid:8668674
Kinderlerer JL et al. Effect of medium-chain fatty acids in mould ripened cheese on the growth of Listeria monocytogenes. 1996 J. Dairy Res. pmid:8933308
Kragh-Hansen U et al. High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. 1996 Biochem. J. pmid:9003380
Powell PK et al. Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8914854
Bookstaff RC et al. Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. 1996 Toxicol. Appl. Pharmacol. pmid:8975784
Petschow BW et al. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. 1996 Antimicrob. Agents Chemother. pmid:8834870
Sherrington EJ et al. Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. 1996 Biochem. Soc. Trans. pmid:8736816