lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Authors Title Published Journal PubMed Link
Shaffer KK et al. Allergenicity and cross-reactivity of coconut oil derivatives: A double-blind randomized controlled pilot study. 2006 Dermatitis pmid:16956456
Fibach E et al. Flow cytofluorometric analysis of the uptake of the fluorescent fatty acid pyrene-dodecanoic acid by human peripheral blood cells. 1988 Cytometry pmid:3208618
Malin-Berdel J and Valet G Flow cytometric determination of esterase and phosphatase activities and kinetics in hematopoietic cells with fluorogenic substrates. 1980 Cytometry pmid:6266787
Hu F et al. Site-directed mutagenesis of Aeromonas hydrophila enoyl coenzyme A hydratase enhancing 3-hydroxyhexanoate fractions of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). 2007 Curr. Microbiol. pmid:17534562
Albers-Jackson B et al. Incorporation of 14C acetate into the phospholipids and fatty acids of rabbit lens in organ culture. 1982-1983 Curr. Eye Res. pmid:7184702
Mo SL et al. Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6. 2009 Curr. Drug Metab. pmid:19702527
Slabu I et al. Investigation of superparamagnetic iron oxide nanoparticles for MR-visualization of surgical implants. 2012 Curr Pharm Biotechnol pmid:22214499
Shacklett BL and Anton PA HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention. 2010 Curr Infect Dis Rep pmid:20174448
Degorce F et al. HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications. 2009 Curr Chem Genomics pmid:20161833
Siri-Tarino PW et al. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. 2010 Curr Atheroscler Rep pmid:20711693
Bosnjak Z Personal narrative of prof. Zeljko Bosnjak, Laureate of Croatian National Decoration for Humanitarian Work. 2006 Croat. Med. J. pmid:17175606
Eldar R Personal narrative of prof. Reuben Eldar, Laureate of Croatian National Decoration for Humanitarian Work. 2006 Croat. Med. J. pmid:17175605
Graham SA Cuphea: a new plant source of medium-chain fatty acids. 1989 Crit Rev Food Sci Nutr pmid:2653730
Hirata-Koizumi M et al. Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats. 2009 Congenit Anom (Kyoto) pmid:20021483
Sharma A and Chauhan RS In silico identification and comparative genomics of candidate genes involved in biosynthesis and accumulation of seed oil in plants. 2012 Comp. Funct. Genomics pmid:22312320
Katoh K et al. Saturated fatty acids suppress adrenocorticotropic hormone (ACTH) release from rat anterior pituitary cells in vitro. 2004 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:15123208
Takahashi N et al. Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. 1995 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:7599976
Amichot M et al. Induction of cytochrome P450 activities in Drosophila melanogaster strains susceptible or resistant to insecticides. 1998 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:9972473
Miura Y Seasonal change and sex difference in laurate hydroxylase activity in frog liver microsomes. 1985 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2865076
Orellana B M et al. Oxidative stress, microsomal and peroxisomal fatty acid oxidation in the liver of rats treated with acetone. 2001 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11301292
Wang-Buhler JL et al. CYP2K6 from zebrafish (Danio rerio): cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme. 2005 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:15907766
Ngo S et al. Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver. 2000 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11246504
Miller RR et al. Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. 2001 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11574286
Orellana M et al. Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption. 2002 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11879783
Orellana M et al. Modulation of cytochrome P450 activity in the kidney of rats following long-term red wine exposure. 2002 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:12161174
Ngo SN et al. The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARalpha) in the common brush tail possum (Trichosurus vulpecula). 2003 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:14559298
Osthoff G et al. Milk composition of three free-ranging African elephant (Loxodonta africana africana) cows during mid lactation. 2007 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:17618152
Takaichi S et al. Fatty acids of astaxanthin esters in krill determined by mild mass spectrometry. 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:14529757
Miura Y and Oda S Oxidation of fatty acids by kidney microsomes of musk shrew (Suncus murinus). 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9530812
Sabourault C et al. Tissue-specific induction and inactivation of cytochrome P450 catalysing lauric acid hydroxylation in the sea bass, Dicentrarchus labrax. 1999 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:10327614
Orellana M et al. Modulation of peroxisomal and microsomal fatty acid oxidation by acetone. A comparative study between liver and kidney. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9972312
Yamasaki M et al. A kinetic and thermodynamic study on hydrolysis of sodium laurate in aqueous phase accompanied by transfer into oil phases containing different organic additives (I). 2005 Colloids Surf B Biointerfaces pmid:16202572
Kim YJ et al. Combination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugs. 2015 Colloids Surf B Biointerfaces pmid:26277712
Krzan M et al. Effect of products of PLA2 catalyzed hydrolysis of DLPC on motion of rising bubbles. 2015 Colloids Surf B Biointerfaces pmid:25724770
Zhao L et al. Surface functionalization of titanium substrates with chitosan-lauric acid conjugate to enhance osteoblasts functions and inhibit bacteria adhesion. 2014 Colloids Surf B Biointerfaces pmid:24880988
Shelma R and Sharma CP Development of lauroyl sulfated chitosan for enhancing hemocompatibility of chitosan. 2011 Colloids Surf B Biointerfaces pmid:21367586
James-Smith MA et al. Effect of chain length on binding of fatty acids to Pluronics in microemulsions. 2008 Colloids Surf B Biointerfaces pmid:18155450
Marciello M et al. Full enzymatic hydrolysis of commercial sucrose laurate by immobilized-stabilized derivatives of lipase from Thermomyces lanuginosa. 2011 Colloids Surf B Biointerfaces pmid:21382701
Marie SK and Shinjo SM Metabolism and brain cancer. 2011 Clinics (Sao Paulo) pmid:21779721
Edirisinghe I et al. Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. 2006 Clin. Sci. pmid:16524362
Haim A et al. Patellofemoral pain syndrome: validity of clinical and radiological features. 2006 Clin. Orthop. Relat. Res. pmid:16788411
Pandey SK et al. A tribute to Charles David Kelman MD: ophthalmologist, inventor and pioneer of phacoemulsification surgery. 2004 Clin. Experiment. Ophthalmol. pmid:15498067
Poudrier J et al. Influence of dendritic cells on B-cell responses during HIV infection. 2012 Clin. Dev. Immunol. pmid:22461837
Campagnoli M et al. Structural analysis, fatty acid and thyroxine binding properties of Vancouver and Naskapi variants of human serum albumin. 2003 Clin. Biochem. pmid:14636873
Chan J et al. Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits. 2008 Clin Ophthalmol pmid:19668396
Jicha GA and Markesbery WR Omega-3 fatty acids: potential role in the management of early Alzheimer's disease. 2010 Clin Interv Aging pmid:20396634
Payne CM et al. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. 2011 Clin Exp Gastroenterol pmid:21753893
Reginster JY et al. Estradiol pharmacokinetics after transdermal application of patches to postmenopausal women: matrix versus reservoir patches. 2000 Climacteric pmid:11910618
Fleming I Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. 2005 Circulation pmid:15630035
Gainer JV et al. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. 2005 Circulation pmid:15611369
Jiang M et al. Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels. 2004 Circ. Res. pmid:14670847
Scholl J Traditional dietary recommendations for the prevention of cardiovascular disease: do they meet the needs of our patients? 2012 Cholesterol pmid:22482040
Chen Y et al. [A new rat model of cerebral infarction based on the injury of vascular endothelial cell]. 2005 Chin J Integr Med pmid:16181534
Fu J et al. Hydrothermal decarboxylation and hydrogenation of fatty acids over Pt/C. 2011 ChemSusChem pmid:21275064
Fauser JK et al. Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress. 2013 Chemotherapy pmid:24356281
Wu B et al. Broad hexagonal columnar mesophases formation in bioinspired transition-metal complexes of simple fatty acid meta-octaester derivatives of meso-tetraphenyl porphyrins. 2015 Chemistry pmid:25619819
Si S et al. In situ synthesis of gold and silver nanoparticles by using redox-active amphiphiles and their phase transfer to organic solvents. 2007 Chemistry pmid:17960550
Coll C et al. Fatty acid carboxylate- and anionic surfactant-controlled delivery systems that use mesoporous silica supports. 2010 Chemistry pmid:20645326
Su Z et al. Rates of fatty acid oxidations by P450 compound I are pH dependent. 2012 Chembiochem pmid:22890798
Mattes RD Oral thresholds and suprathreshold intensity ratings for free fatty acids on 3 tongue sites in humans: implications for transduction mechanisms. 2009 Chem. Senses pmid:19357229
Barham P et al. Molecular gastronomy: a new emerging scientific discipline. 2010 Chem. Rev. pmid:20170128
Grillo MP and Hua F Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes. 2008 Chem. Res. Toxicol. pmid:18680316
Clarke SE et al. Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. 1994 Nov-Dec Chem. Res. Toxicol. pmid:7696540
Iwahashi M et al. Dynamical dimer structure and liquid structure of fatty acids in their binary liquid mixture: dodecanoic and 3-phenylpropionic acids system. 2004 Chem. Phys. Lipids pmid:15081860
Inoue T et al. Solid-liquid phase behavior of binary fatty acid mixtures. 2. Mixtures of oleic acid with lauric acid, myristic acid, and palmitic acid. 2004 Chem. Phys. Lipids pmid:14725999
Fauconnot L et al. Chemical synthesis and NMR characterization of structured polyunsaturated triacylglycerols. 2006 Chem. Phys. Lipids pmid:16405879
Costa MC et al. The solid-liquid phase diagrams of binary mixtures of consecutive, even saturated fatty acids. 2009 Chem. Phys. Lipids pmid:19520067
Chaleepa K et al. Effect of additives on isothermal crystallization kinetics and physical characteristics of coconut oil. 2010 Chem. Phys. Lipids pmid:20346930
Mirsky VM Effect of the lipid hydrolysis products on the phospholipase A2 action towards lipid monolayer. 1994 Chem. Phys. Lipids pmid:8013058
Iwahashi M et al. Dynamical dimer structure and liquid structure of fatty acids in their binary liquid mixture: decanoic/octadecanoic acid and decanoic/dodecanoic acid systems. 2005 Chem. Phys. Lipids pmid:15642581
Uchida T et al. Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers. 2001 Chem. Pharm. Bull. pmid:11605651
de Regil-Hernández R et al. New green synthesis and formulations of acyclovir prodrugs. 2011 Chem. Pharm. Bull. pmid:21881250
Liu CH and Huang HY In vitro anti-propionibacterium activity by curcumin containing vesicle system. 2013 Chem. Pharm. Bull. pmid:23546001
Kamachi S et al. Spectrophotometric assay for lipase in serum using a chromogenic substrate, Orange I laurate. 1983 Chem. Pharm. Bull. pmid:6652817
Ogiso T et al. Enhancement effect of lauric acid on the rectal absorption of propranolol from suppository in rats. 1991 Chem. Pharm. Bull. pmid:1806286
Watanabe T et al. Co-suppression by nicardipine, a calcium antagonist, of induction of microsomal lauric acid hydroxylation with peroxisome proliferation in clofibrate-treated rat liver. 1991 Chem. Pharm. Bull. pmid:1914008
Tran NH et al. Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes. 2011 Chem. Commun. (Camb.) pmid:21975564
Weissenborn MJ et al. Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s. 2016 Chem. Commun. (Camb.) pmid:27074906
Ribot F et al. In situ evaluation of interfacial affinity in CeO2 based hybrid nanoparticles by pulsed field gradient NMR. 2005 Chem. Commun. (Camb.) pmid:15719102
Sun CQ et al. The antimicrobial properties of milkfat after partial hydrolysis by calf pregastric lipase. 2002 Chem. Biol. Interact. pmid:12076524
Bacher MA and Gibson GG Chlorophenoxyacid herbicides induce microsomal cytochrome P-450 IVA1 (P-452) in rat liver. 1988 Chem. Biol. Interact. pmid:3365825
Charest-Boule L et al. Influence of free fatty acid anion on the binding of warfarin to cytoplasmic proteins from rat liver. 1980 Chem. Biol. Interact. pmid:7356538
Weinkam RJ et al. Protein mediated chemical reactions of chloroethylnitrosoureas. 1980 Chem. Biol. Interact. pmid:7389008
Guan X et al. Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid. 1998 Chem. Biol. Interact. pmid:9566728
Staab CA et al. Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3. 2009 Chem. Biol. Interact. pmid:19428350
Mo S et al. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. 2008 Chem. Biol. pmid:18291318
Marynka K et al. In vitro discriminative antipseudomonal properties resulting from acyl substitution of N-terminal sequence of dermaseptin s4 derivatives. 2007 Chem. Biol. pmid:17254954
Liu J et al. Anti-androgenic activity of fatty acids. 2009 Chem. Biodivers. pmid:19353546
El Ayeb-Zakhama A et al. Chemical composition and allelopathic potential of essential oils obtained from Acacia cyanophylla Lindl. Cultivated in Tunisia. 2015 Chem. Biodivers. pmid:25879505
Cecotti R et al. Determination of the volatile fraction of Polygonum bistorta L. at different growing stages and evaluation of its antimicrobial activity against two major honeybee (Apis mellifera) pathogens. 2012 Chem. Biodivers. pmid:22344911
Salles HC et al. The venomous secrets of the web droplets from the viscid spiral of the orb-weaver spider Nephila clavipes (Araneae, Tetragnatidae). 2006 Chem. Biodivers. pmid:17193305
Blazević I et al. Hedge mustard (Sisymbrium officinale): chemical diversity of volatiles and their antimicrobial activity. 2010 Chem. Biodivers. pmid:20730965
Lv GP et al. Comparison of sterols and fatty acids in two species of Ganoderma. 2012 Chem Cent J pmid:22293530
Siano A et al. Interaction of acylated and substituted antimicrobial peptide analogs with phospholipid-polydiacetylene vesicles. Correlation with their biological properties. 2011 Chem Biol Drug Des pmid:21496212
Starha L and Chalabala M [Oral long-acting drugs. 8. Effects of palmitic and lauric acid and their glycerine esters on the slowing of the drug release]. 1972 Cesk Farm pmid:5075740
Bainbridge BW et al. Expression of a Porphyromonas gingivalis lipid A palmitylacyltransferase in Escherichia coli yields a chimeric lipid A with altered ability to stimulate interleukin-8 secretion. 2006 Cell. Microbiol. pmid:16367871
Ramírez-Agudelo ME et al. Fatty acid profile during the differentiation and infection with Mycobacterium tuberculosis of mononuclear phagocytes of patients with TB and healthy individuals. 2011 Cell. Immunol. pmid:21571261
Nordström T et al. Inhibition of CD3-induced Ca2+ signals in Jurkat T-cells by myristic acid. 1991 Cell Calcium pmid:1834341
Thibaut R et al. Assessment of metabolic capabilities of PLHC-1 and RTL-W1 fish liver cell lines. 2009 Cell Biol. Toxicol. pmid:19142739
Hayes ML Reduction in acid tolerance of Streptococcus downeii by fluoride and potassium laurate. 1994 Caries Res. pmid:8156568