lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Takehara K et al. | Inhibition of firefly luciferase by alkane analogues. | 2005 | Biochim. Biophys. Acta | pmid:15652187 |
Christensen E et al. | Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. | 1989 | Biochim. Biophys. Acta | pmid:2752017 |
Larsson A and Erlanson-Albertsson C | Effect of phosphatidylcholine and free fatty acids on the activity of pancreatic lipase-colipase. | 1986 | Biochim. Biophys. Acta | pmid:3707983 |
Dlasková A et al. | Certain aspects of uncoupling due to mitochondrial uncoupling proteins in vitro and in vivo. | 2006 May-Jun | Biochim. Biophys. Acta | pmid:16781660 |
Rioux V et al. | Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations. | 2011 | Biochim. Biophys. Acta | pmid:20920594 |
Mortensen PB and Gregersen N | The biological origin of ketotic dicarboxylic aciduria. In vivo and in vitro investigations of the omega-oxidation of C6-C16-monocarboxylic acids in unstarved, starved and diabetic rats. | 1981 | Biochim. Biophys. Acta | pmid:6798996 |
Stewart JM and Blakely JA | Long chain fatty acids inhibit and medium chain fatty acids activate mammalian cardiac hexokinase. | 2000 | Biochim. Biophys. Acta | pmid:10760476 |
Simonyan RA et al. | Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles. | 2001 | Biochim. Biophys. Acta | pmid:11334791 |
Ichihara K et al. | Some properties of the fatty alcohol oxidation system and reconstitution of microsomal oxidation activity in intestinal mucosa. | 1986 | Biochim. Biophys. Acta | pmid:3530336 |
Hibbs AR and Marzuki S | An assessment of the ability of yeast cells to incorporate photolabile fatty acids into their membrane phospholipids in vivo. | 1986 | Biochim. Biophys. Acta | pmid:3535894 |
Nilsson A et al. | Studies on the interrelated stimulation of microsomal omega-oxidation and peroxisomal beta-oxidation in rat liver with a partially hydrogenated fish oil diet. | 1987 | Biochim. Biophys. Acta | pmid:3607073 |
Samartsev VN et al. | Comparative study on uncoupling effects of laurate and lauryl sulfate on rat liver and skeletal muscle mitochondria. | 2000 | Biochim. Biophys. Acta | pmid:10924910 |
Terada H et al. | Heat denaturation of serum albumin monitored by 1-anilino-naphthalene-8-sulfonate. | 1980 | Biochim. Biophys. Acta | pmid:7378445 |
Fournel S et al. | Structure-dependent induction of bilirubin glucuronidation and lauric acid 12-hydroxylation by arylcarboxylic acids chemically related to clofibrate. | 1985 | Biochim. Biophys. Acta | pmid:3931693 |
Lehmler HJ and Bummer PM | Mixing of perfluorinated carboxylic acids with dipalmitoylphosphatidylcholine. | 2004 | Biochim. Biophys. Acta | pmid:15328046 |
Bugaut M et al. | An examination of the stereochemical course of acylation of 2-monoacylglycerols by rat intestinal villus cells using [2H3]palmitic acid. | 1984 | Biochim. Biophys. Acta | pmid:6696934 |
McDonough V et al. | Mutations in erg4 affect the sensitivity of Saccharomyces cerevisiae to medium-chain fatty acids. | 2002 | Biochim. Biophys. Acta | pmid:12020638 |
Miura Y et al. | omega- and (omega--1)-hydroxylation of fatty acids by frog liver microsomes. Substrate specificity and other properties. | 1978 | Biochim. Biophys. Acta | pmid:309772 |
Ramsey BL and Westphal U | Steroid-protein interactions. 40. The effect of fatty acids on progesterone binding to human serum albumin. | 1978 | Biochim. Biophys. Acta | pmid:638175 |
Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
Ryals PE et al. | Lipid modification during cytodifferentiation of Tetrahymena vorax. Whole cell phospholipids and triacylglycerols of microstomal and macrostomal phenotypes. | 1989 | Biochim. Biophys. Acta | pmid:2730920 |
Nashima K et al. | Studies on cephalopod rhodopsin. Fatty acid esters of sucrose as effective detergents. | 1978 | Biochim. Biophys. Acta | pmid:708776 |
Ryan MT and Chopra RK | The paradoxical effect of fatty acid on steroid-albumin interaction. | 1976 | Biochim. Biophys. Acta | pmid:1260006 |
Hansted JG et al. | Effect of protein-surfactant interactions on aggregation of β-lactoglobulin. | 2011 | Biochim. Biophys. Acta | pmid:21440683 |
Andersen Borge GI et al. | Fatty acid alpha-oxidation of tetradecylthioacetic acid and tetradecylthiopropionic acid in cucumber (Cucumis sativus). | 1998 | Biochim. Biophys. Acta | pmid:9795197 |
Park YJ et al. | A novel dienelactone hydrolase from the thermoacidophilic archaeon Sulfolobus solfataricus P1: purification, characterization, and expression. | 2010 | Biochim. Biophys. Acta | pmid:20655986 |
Rose RC | Solubility properties of reduced and oxidized ascorbate as determinants of membrane permeation. | 1987 | Biochim. Biophys. Acta | pmid:3103695 |
Harsfalvi J et al. | Lipids associated with tissue transglutaminase. | 1987 | Biochim. Biophys. Acta | pmid:2879570 |
Guerranti R et al. | Inhibition and regulation of rat liver L-threonine dehydrogenase by different fatty acids and their derivatives. | 2001 | Biochim. Biophys. Acta | pmid:11731084 |
Popov VN et al. | Effects of cold exposure in vivo and uncouplers and recouplers in vitro on potato tuber mitochondria. | 2002 | Biochim. Biophys. Acta | pmid:11997132 |
Fournel S et al. | Stereospecific induction of rat liver bilirubin UDPglucuronosyltransferase and lauric acid 12-hydroxylation by the isomers of 2-phenylpropionic acid. | 1986 | Biochim. Biophys. Acta | pmid:3089296 |
Dhers L et al. | Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands. | 2017 | Biochim Biophys Acta Gen Subj | pmid:27456766 |
Samartsev VN et al. | Temperature dependence of rat liver mitochondrial respiration with uncoupling of oxidative phosphorylation by fatty acids. Influence of inorganic phosphate. | 2003 | Biochemistry Mosc. | pmid:12943505 |
Krasikova IN et al. | Chemical characterization of lipid A from some marine proteobacteria. | 2001 | Biochemistry Mosc. | pmid:11703190 |
Samartsev VN et al. | Involvement of aspartate/glutamate antiporter in uncoupling effect of fatty acids in heart mitochondria. | 1998 | Biochemistry Mosc. | pmid:9632895 |
Zheng YM et al. | Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate. | 2003 | Biochemistry | pmid:12693958 |
Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
Raner GM et al. | Regioselective peroxo-dependent heme alkylation in P450(BM3)-F87G by aromatic aldehydes: effects of alkylation on cataysis. | 2002 | Biochemistry | pmid:12135382 |
Six DA et al. | Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. | 2008 | Biochemistry | pmid:18656959 |
Cheng XL et al. | The biosynthetic incorporation of short-chain linear saturated fatty acids by Acholeplasma laidlawii B may suppress cell growth by perturbing membrane lipid polar headgroup distribution. | 2002 | Biochemistry | pmid:12093284 |
Straub P et al. | Differential effects of mutations in substrate recognition site 1 of cytochrome P450 2C2 on lauric acid and progesterone hydroxylation. | 1994 | Biochemistry | pmid:8025107 |
Ost TW et al. | Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3. | 2001 | Biochemistry | pmid:11695888 |
CaJacob CA and Ortiz de Montellano PR | Mechanism-based in vivo inactivation of lauric acid hydroxylases. | 1986 | Biochemistry | pmid:3490272 |
Loughran PA et al. | Identification of unique amino acids that modulate CYP4A7 activity. | 2000 | Biochemistry | pmid:11106489 |
Hamilton SE et al. | Identification of the high-affinity lipid binding site in Escherichia coli pyruvate oxidase. | 1986 | Biochemistry | pmid:3545288 |
Modi S et al. | NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. | 1995 | Biochemistry | pmid:7619797 |
Yeom H et al. | The role of Thr268 in oxygen activation of cytochrome P450BM-3. | 1995 | Biochemistry | pmid:7578081 |
Haines DC et al. | Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel. | 2008 | Biochemistry | pmid:18298086 |
Gasymov OK et al. | Ligand binding site of tear lipocalin: contribution of a trigonal cluster of charged residues probed by 8-anilino-1-naphthalenesulfonic acid. | 2008 | Biochemistry | pmid:18179255 |
Kim D et al. | Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. | 2014 | Biochemistry | pmid:25203493 |
Murataliev MB and Feyereisen R | Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. | 1996 | Biochemistry | pmid:8942669 |
Murataliev MB et al. | Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. | 1997 | Biochemistry | pmid:9204888 |
Winkler E et al. | Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue. | 1997 | Biochemistry | pmid:8993328 |
Kantor HL and Prestegard JH | Fusion of fatty acid containing lecithin vesicles. | 1975 | Biochemistry | pmid:1125198 |
Poli-Scaife S et al. | The substrate binding site of human liver cytochrome P450 2C9: an NMR study. | 1997 | Biochemistry | pmid:9335524 |
Zheng YM et al. | Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1. | 1998 | Biochemistry | pmid:9737862 |
Davis JH | 2H nuclear magnetic resonance of exchange-labeled gramicidin in an oriented lyotropic nematic phase. | 1988 | Biochemistry | pmid:2450569 |
Haining RL et al. | Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. | 1999 | Biochemistry | pmid:10079071 |
Makovitzki A and Shai Y | pH-dependent antifungal lipopeptides and their plausible mode of action. | 2005 | Biochemistry | pmid:16008362 |
Richieri GV et al. | Binding kinetics of engineered mutants provide insight about the pathway for entering and exiting the intestinal fatty acid binding protein. | 1999 | Biochemistry | pmid:10231541 |
Noble MA et al. | Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. | 1998 | Biochemistry | pmid:9843385 |
Lawson RJ et al. | Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI. | 2004 | Biochemistry | pmid:15449930 |
Echtay KS et al. | Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1). | 2001 | Biochemistry | pmid:11318647 |
Reynolds CM and Raetz CR | Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. | 2009 | Biochemistry | pmid:19754149 |
Sanghani PC et al. | Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. | 2002 | Biochemistry | pmid:12196016 |
Orlowski M et al. | Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. | 1993 | Biochemistry | pmid:8431436 |
Byard J et al. | Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. | 1996 | Biochem. Soc. Trans. | pmid:8736866 |
Gibson GG and Bains SK | Cytochrome P-450 isoenzymes involved in fatty acid metabolism. | 1985 | Biochem. Soc. Trans. | pmid:4065418 |
Makowska JM et al. | Species differences in the hepatic response to a potent peroxisome proliferator. | 1989 | Biochem. Soc. Trans. | pmid:2628085 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Abigor RD et al. | Lipase-catalysed production of biodiesel fuel from some Nigerian lauric oils. | 2000 | Biochem. Soc. Trans. | pmid:11171279 |
Magdalou J et al. | Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. | 1988 | Biochem. Pharmacol. | pmid:2840913 |
Amet Y et al. | Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. | 1995 | Biochem. Pharmacol. | pmid:8615855 |
Williams DE et al. | Sex differences in cytochrome P-450 isozyme composition and activity in kidney microsomes of mature rainbow trout. | 1986 | Biochem. Pharmacol. | pmid:3718543 |
Pons N et al. | Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. | 2003 | Biochem. Pharmacol. | pmid:12907239 |
Ronis MJ et al. | Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs). | 1994 | Biochem. Pharmacol. | pmid:7986207 |
Sharma R et al. | Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies. | 1988 | Biochem. Pharmacol. | pmid:3355594 |
Kikuta Y et al. | Expression and induction of cytochrome P450s in rabbit parotid glands. | 2001 | Biochem. Pharmacol. | pmid:11389885 |
Past MR and Cook DE | Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450. | 1982 | Biochem. Pharmacol. | pmid:7150359 |
Kocarek TA and Feller DR | Induction of peroxisomal fatty acyl-CoA oxidase and microsomal laurate hydroxylase activities by beclobric acid and two metabolites in primary cultures of rat hepatocytes. | 1987 | Biochem. Pharmacol. | pmid:3632723 |
De Matteis F et al. | Peroxidase-like activity of uncoupled cytochrome P450: studies with bilirubin and toxicological implications of uncoupling. | 2012 | Biochem. Pharmacol. | pmid:22564776 |
Bains SK et al. | Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3929789 |
Hornung B et al. | Medium chain length fatty acids stimulate triacylglycerol synthesis in tissue culture cells. | 1992 | Biochem. Pharmacol. | pmid:1739406 |
Knickle LC et al. | The suppression of hepatic cytochrome P4504A mRNA mediated by the interferon inducer polyinosinic acid.polycytidylic acid. | 1992 | Biochem. Pharmacol. | pmid:1380810 |
RodrÃguez-Penas D et al. | Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes. | 2011 | Biochem. Pharmacol. | pmid:21640714 |
Sivapathasundaram S et al. | A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. | 2001 | Biochem. Pharmacol. | pmid:11585060 |
Amet Y et al. | Cytochrome P450 4A and 2E1 expression in human kidney microsomes. | 1997 | Biochem. Pharmacol. | pmid:9113097 |
Okita RT et al. | Lauric acid hydroxylation in human liver and kidney cortex microsomes. | 1979 | Biochem. Pharmacol. | pmid:533546 |
Imaoka S et al. | Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. | 1997 | Biochem. Pharmacol. | pmid:9310344 |
Hvattum E et al. | Microsomal oxidation of dodecylthioacetic acid (a 3-thia fatty acid) in rat liver. | 1991 Mar 15-Apr 1 | Biochem. Pharmacol. | pmid:1672593 |
Sharma RK et al. | Role of hepatic and renal cytochrome P-450 IVA1 in the metabolism of lipid substrates. | 1989 | Biochem. Pharmacol. | pmid:2554928 |
Kocarek TA and Feller DR | Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes. | 1989 | Biochem. Pharmacol. | pmid:2597188 |
Kitagawa S et al. | Effects of alkyl gallates on P-glycoprotein function. | 2005 | Biochem. Pharmacol. | pmid:16139251 |
Pham MA et al. | Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. | 1989 | Biochem. Pharmacol. | pmid:2500129 |
Swinney DC et al. | A novel rat hepatic clofibrate-inducible cytochrome P450 that is not a lauric acid hydroxylase. | 1991 | Biochem. Pharmacol. | pmid:1662512 |
Lundgren B et al. | Effects of dietary treatment with 11 dicarboxylic acids, diethylcarboxylic esters and fatty acids on peroxisomal fatty acid beta-oxidation, epoxide hydrolases and lauric acid omega-hydroxylation in mouse liver. | 1992 | Biochem. Pharmacol. | pmid:1540233 |
Thomas H et al. | Effect of hypolipidemic compounds on lauric acid hydroxylation and phase II enzymes. | 1989 | Biochem. Pharmacol. | pmid:2500933 |
Raza H and Levine WG | Effect of hypolipidemic drugs on the metabolism of lauric acid and dimethylaminoazobenzene by rat liver microsomes. | 1987 | Biochem. Pharmacol. | pmid:3103631 |
Nakamura M et al. | Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A. | 1994 | Biochem. Pharmacol. | pmid:7980643 |
Muller DN et al. | Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. | 2007 | Biochem. J. | pmid:17112342 |