lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kolattukudy PE and Rogers L | Biosynthesis of 3-hydroxy fatty acids, the pheromone components of female mallard ducks, by cell-free preparations from the uropygial gland. | 1987 | Arch. Biochem. Biophys. | pmid:3813530 |
Shet Ms et al. | The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. | 1996 | Arch. Biochem. Biophys. | pmid:8651697 |
Brodersen R et al. | Cobinding of bilirubin and sulfonamide and of two bilirubin molecules to human serum albumin: a site model. | 1987 | Arch. Biochem. Biophys. | pmid:3813550 |
Lewis DF | Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | 2003 | Arch. Biochem. Biophys. | pmid:12464242 |
Puchkaev AV et al. | Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. | 2003 | Arch. Biochem. Biophys. | pmid:12464244 |
Williams DE et al. | Regiospecific hydroxylation of lauric acid at the (omega-1) position by hepatic and kidney microsomal cytochromes P-450 from rainbow trout. | 1984 | Arch. Biochem. Biophys. | pmid:6732245 |
Salaun JP et al. | Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of the lauric acid in-chain hydroxylase from Helianthus tuberosus L. by unsaturated substrate analogs. | 1984 | Arch. Biochem. Biophys. | pmid:6742847 |
Finlayson MJ et al. | Differential expression of cytochrome P-450 1 and related forms in rabbit liver and kidney. | 1987 | Arch. Biochem. Biophys. | pmid:3492962 |
Kahn RA et al. | A conservative amino acid substitution alters the regiospecificity of CYP94A2, a fatty acid hydroxylase from the plant Vicia sativa. | 2001 | Arch. Biochem. Biophys. | pmid:11437349 |
Capdevila J et al. | Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. | 1985 | Arch. Biochem. Biophys. | pmid:3933431 |
Norman HA and Thompson GA | Effects of low-temperature stress on the metabolism of phosphatidylglycerol molecular species in Dunaliella salina. | 1985 | Arch. Biochem. Biophys. | pmid:4051499 |
Powell PK et al. | Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8914854 |
Lu P et al. | Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. | 1997 | Arch. Biochem. Biophys. | pmid:8990261 |
Okita RT and Okita JR | Characterization of a cytochrome P450 from di(2-ethylhexyl) phthalate-treated rats which hydroxylates fatty acids. | 1992 | Arch. Biochem. Biophys. | pmid:1567203 |
Girvan HM et al. | Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer. | 2011 | Arch. Biochem. Biophys. | pmid:20868649 |
Chaurasia CS et al. | Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. | 1995 | Arch. Biochem. Biophys. | pmid:7872779 |
Cowart LA et al. | Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. | 2001 | Arch. Biochem. Biophys. | pmid:11368173 |
Duncan T et al. | A glycoprotein binding retinoids and fatty acids is present in Drosophila. | 1994 | Arch. Biochem. Biophys. | pmid:8031123 |
Puchkaev AV and Ortiz de Montellano PR | The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. | 2005 | Arch. Biochem. Biophys. | pmid:15629120 |
Sato H et al. | Multiple binding of bilirubin to human serum albumin and cobinding with laurate. | 1988 | Arch. Biochem. Biophys. | pmid:2829743 |