lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kroetz DL et al. | Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. | 1997 | Mol. Pharmacol. | pmid:9281597 |
Sunshine MG et al. | Mutation of the htrB gene in a virulent Salmonella typhimurium strain by intergeneric transduction: strain construction and phenotypic characterization. | 1997 | J. Bacteriol. | pmid:9287009 |
Winkelaar GB et al. | Fat absorption after small intestinal transplantation in the rat. | 1997 | Transplantation | pmid:9293866 |
Imaoka S et al. | Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. | 1997 | Biochem. Pharmacol. | pmid:9310344 |
Maves SA et al. | Decreased substrate affinity upon alteration of the substrate-docking region in cytochrome P450(BM-3). | 1997 | FEBS Lett. | pmid:9315688 |
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Buhler DR et al. | The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450s. | 1997 | Drug Metab. Dispos. | pmid:9321521 |
Westergaard H and Dietschy JM | The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell. | 1976 | J. Clin. Invest. | pmid:932213 |
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Green PR and Geer BW | Changes in the fatty acid composition of Drosophila melanogaster during development and ageing. | 1979 | Arch. Int. Physiol. Biochim. | pmid:93438 |
Wiberg E et al. | Fatty acid distribution and lipid metabolism in developing seeds of laurate-producing rape (Brassica napus L.). | 1997 | Planta | pmid:9431681 |
Lindmark T et al. | Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435199 |
Lind KE and Moller JV | Ligand-apomyoglobin interactions. Configurational adaptability of the haem-binding site. | 1976 | Biochem. J. | pmid:949328 |
Björkhem I and Kallner A | Hepatic 7alpha-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs. | 1976 | J. Lipid Res. | pmid:950498 |
Miura Y and Oda S | Oxidation of fatty acids by kidney microsomes of musk shrew (Suncus murinus). | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9530812 |
Guan X et al. | Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid. | 1998 | Chem. Biol. Interact. | pmid:9566728 |
Amet Y et al. | P-450-dependent metabolism of lauric acid in alcoholic liver disease: comparison between rat liver and kidney microsomes. | 1998 | Alcohol. Clin. Exp. Res. | pmid:9581653 |
Samartsev VN et al. | Involvement of aspartate/glutamate antiporter in uncoupling effect of fatty acids in heart mitochondria. | 1998 | Biochemistry Mosc. | pmid:9632895 |
Macdonald ID et al. | Fatty acid-induced alteration of the porphyrin macrocycle of cytochrome P450 BM3. | 1998 | Biophys. J. | pmid:9635777 |