lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Uchida T et al. | Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers. | 2001 | Chem. Pharm. Bull. | pmid:11605651 |
Jabůrek M et al. | Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling. | 2001 | J. Biol. Chem. | pmid:11468281 |
Sivapathasundaram S et al. | A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. | 2001 | Biochem. Pharmacol. | pmid:11585060 |
Fomuso LB and Akoh CC | Enzymatic modification of high-laurate canola to produce margarine fat. | 2001 | J. Agric. Food Chem. | pmid:11559158 |
Aoki T et al. | Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. | 2001 | Arzneimittelforschung | pmid:11304935 |
Echtay KS et al. | Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1). | 2001 | Biochemistry | pmid:11318647 |
Lee JY et al. | Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | 2001 | J. Biol. Chem. | pmid:11278967 |
Park SJ et al. | Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. | 2001 | Biotechnol. Bioeng. | pmid:11353413 |
Gross V et al. | Inhibition of pressure natriuresis in mice lacking the AT2 receptor. | 2000 | Kidney Int. | pmid:10620200 |
Hoch U et al. | Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases. | 2000 | Arch. Biochem. Biophys. | pmid:10620324 |
Aussel L et al. | Novel variation of lipid A structures in strains of different Yersinia species. | 2000 | FEBS Lett. | pmid:10620712 |
Nakagawa T et al. | Peroxisomal membrane protein Pmp47 is essential in the metabolism of middle-chain fatty acid in yeast peroxisomes and Is associated with peroxisome proliferation. | 2000 | J. Biol. Chem. | pmid:10652339 |
Lee SH et al. | Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high-cell-density cultivation of Aeromonas hydrophila. | 2000 | Biotechnol. Bioeng. | pmid:10592522 |
Casolo V et al. | The role of mild uncoupling and non-coupled respiration in the regulation of hydrogen peroxide generation by plant mitochondria. | 2000 | FEBS Lett. | pmid:10828450 |
Sinninghe Damsté JS et al. | Structural identification of the diester preen-gland waxes of the red knot (Calidris canutus). | 2000 | J. Nat. Prod. | pmid:10757724 |
Song B et al. | Description of strain 3CB-1, a genomovar of Thauera aromatica, capable of degrading 3-chlorobenzoate coupled to nitrate reduction. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758860 |
van der Bijl P et al. | Permeation of sumatriptan through human vaginal and buccal mucosa. | 2000 | Headache | pmid:10759913 |
Stewart JM and Blakely JA | Long chain fatty acids inhibit and medium chain fatty acids activate mammalian cardiac hexokinase. | 2000 | Biochim. Biophys. Acta | pmid:10760476 |
Sheffield C | The new laureate speaks. | 2000 | Nature | pmid:10766219 |
Ayorinde FO et al. | Determination of the fatty acid composition of saponified vegetable oils using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | 2000 | Rapid Commun. Mass Spectrom. | pmid:10775096 |
Sulikowski GA et al. | Investigations into a biomimetic approach toward CP-225,917 and CP-263,114. | 2000 | J. Org. Chem. | pmid:10813939 |
Hsu AF et al. | Immobilization of Pseudomonas cepacia lipase in a phyllosilicate sol-gel matrix: effectiveness as a biocatalyst. | 2000 | Biotechnol. Appl. Biochem. | pmid:10814587 |
Dong GC et al. | Preparation and characterization of surface-modified calcium hydrogenphosphate by hexamethylene diisocyanates. | 2000 | Biomed Sci Instrum | pmid:10834217 |
Hong JT and Glauert HP | Effect of extracellular matrix on the expression of peroxisome proliferation associated genes in cultured rat hepatocytes. | 2000 | Toxicol In Vitro | pmid:10793296 |
Govender T et al. | Defining the drug incorporation properties of PLA-PEG nanoparticles. | 2000 | Int J Pharm | pmid:10794931 |
Pereira JR et al. | Inversion in the change of the refractive index and memory effect near the nematic-isotropic phase transition in a lyotropic liquid crystal. | 2000 | Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics | pmid:11031592 |
Buhler DR et al. | Effects of 17beta-estradiol and testosterone on hepatic mRNA/protein levels and catalytic activities of CYP2M1, CYP2K1, and CYP3A27 in rainbow trout (Oncorhynchus mykiss). | 2000 | Toxicol. Appl. Pharmacol. | pmid:11032764 |
Pantaler E et al. | Acceleration of phospholipid flip-flop in the erythrocyte membrane by detergents differing in polar head group and alkyl chain length. | 2000 | Biochim. Biophys. Acta | pmid:11118549 |
Soetanto K and Chan M | Study on the lifetime and attenuation properties of microbubbles coated with carboxylic acid salts. | 2000 | Ultrasonics | pmid:11106009 |
Loughran PA et al. | Identification of unique amino acids that modulate CYP4A7 activity. | 2000 | Biochemistry | pmid:11106489 |
Yang YH et al. | Heterologous expression of CYP2K1 and identification of the expressed protein (BV-CYP2K1) as lauric acid (omega-1)-hydroxylase and aflatoxin B1 exo-epoxidase. | 2000 | Drug Metab. Dispos. | pmid:11038153 |
Hashemi E et al. | Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices. | 2000 | Toxicology | pmid:10967402 |
Giorgi M et al. | Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10986015 |
Imaishi H et al. | CYP78A1 preferentially expressed in developing inflorescences of Zea mays encoded a cytochrome P450-dependent lauric acid 12-monooxygenase. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10993158 |
Nielsen AD et al. | Thermochemistry of the specific binding of C12 surfactants to bovine serum albumin. | 2000 | Biochim. Biophys. Acta | pmid:11004550 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Saffert A et al. | A dual function alpha-dioxygenase-peroxidase and NAD(+) oxidoreductase active enzyme from germinating pea rationalizing alpha-oxidation of fatty acids in plants. | 2000 | Plant Physiol. | pmid:10938370 |
Toshima Y et al. | A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor. | 2000 | Stroke | pmid:10978059 |
Santoyo S and Ygartua P | Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application. | 2000 | Eur J Pharm Biopharm | pmid:10962234 |
Ohk SH and Kuramitsu HK | A novel antibacterial agent derived from the C-terminal domain of streptococcus mutans GTP-binding protein. | 2000 | J. Antimicrob. Chemother. | pmid:10882696 |
Kawashima H et al. | Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. | 2000 | Arch. Biochem. Biophys. | pmid:10860550 |
Hoch U et al. | Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases. | 2000 | J. Biol. Chem. | pmid:10869363 |
Imai Y et al. | Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis (peroxygenase P450(SPalpha). | 2000 | J. Biochem. | pmid:10920253 |
Samartsev VN et al. | Comparative study on uncoupling effects of laurate and lauryl sulfate on rat liver and skeletal muscle mitochondria. | 2000 | Biochim. Biophys. Acta | pmid:10924910 |
Arrol S et al. | The effects of fatty acids on apolipoprotein B secretion by human hepatoma cells (HEP G2). | 2000 | Atherosclerosis | pmid:10856517 |
Tang L et al. | A kinetic study of the synthesis of ascorbate fatty acid esters catalysed by immobilized lipase in organic media. | 2000 | Biotechnol. Appl. Biochem. | pmid:10918036 |
Ogiso T et al. | Percutaneous penetration of ozagrel and the enhancement produced by saturated fatty acids. | 2000 | Biol. Pharm. Bull. | pmid:10919364 |
Buszello K et al. | The influence of alkali fatty acids on the properties and the stability of parenteral O/W emulsions modified with solutol HS 15. | 2000 | Eur J Pharm Biopharm | pmid:10704897 |
Lake BG et al. | Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig. | 2000 | Mutat. Res. | pmid:10725474 |
Saito A et al. | Effects of capsaicin on biliary free fatty acids in rats. | 2000 | Int J Vitam Nutr Res | pmid:10683757 |
Tsuge T et al. | Molecular cloning of two (R)-specific enoyl-CoA hydratase genes from Pseudomonas aeruginosa and their use for polyhydroxyalkanoate synthesis. | 2000 | FEMS Microbiol. Lett. | pmid:10713420 |
Soetanto K and Chan M | Fundamental studies on contrast images from different-sized microbubbles: analytical and experimental studies. | 2000 | Ultrasound Med Biol | pmid:10687796 |
Kamm W et al. | Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2). | 2000 | Eur J Pharm Sci | pmid:10767598 |
Betts KS | Laureate extols genetic engineering's value for aiding hungry developing nations. | 2000 | Environ. Sci. Technol. | pmid:21657573 |
Sidhu SS et al. | Fatty acid-induced cholecystokinin secretion and changes in intracellular Ca2+ in two enteroendocrine cell lines, STC-1 and GLUTag. | 2000 | J. Physiol. (Lond.) | pmid:11018115 |
Wiberg E et al. | The distribution of caprylate, caprate and laurate in lipids from developing and mature seeds of transgenic Brassica napus L. | 2000 | Planta | pmid:11219581 |
Abigor RD et al. | Lipase-catalysed production of biodiesel fuel from some Nigerian lauric oils. | 2000 | Biochem. Soc. Trans. | pmid:11171279 |
Ngo S et al. | Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver. | 2000 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11246504 |
Kwok CS et al. | Surface modification of polymers with self-assembled molecular structures: multitechnique surface characterization. | 2000 | Biomacromolecules | pmid:11709836 |
Reginster JY et al. | Estradiol pharmacokinetics after transdermal application of patches to postmenopausal women: matrix versus reservoir patches. | 2000 | Climacteric | pmid:11910618 |
Cunha MT et al. | Effect of salts and surfactants on the partitioning of Fusarium solani pisi cutinase in aqueous two-phase systems of thermoseparating ethylene oxide/propylene oxide random copolymer and hydroxypropyl starch. | 2000 | Bioseparation | pmid:11321518 |
Amet Y et al. | Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes. | 2000 | Eur J Nutr | pmid:11395987 |
Kikuta Y et al. | Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. | 2000 | Arch. Biochem. Biophys. | pmid:11185557 |
Goodfriend TL et al. | Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans. | 1999 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10471129 |
Bardi L et al. | Saccharomyces cerevisiae cell fatty acid composition and release during fermentation without aeration and in absence of exogenous lipids. | 1999 | Int. J. Food Microbiol. | pmid:10357281 |
NTP Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS NO. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies). | 1999 | Natl Toxicol Program Tech Rep Ser | pmid:12571683 | |
Tsai YH et al. | Mechanisms mediating lipoprotein responses to diets with medium-chain triglyceride and lauric acid. | 1999 | Lipids | pmid:10574653 |
Cazeils JL et al. | Lipid composition of hepatocyte plasma membranes from geese overfed with corn. | 1999 | Lipids | pmid:10574658 |
Imaishi H et al. | Encoding of a cytochrome P450-dependent lauric acid monooxygenase by CYP703A1 specifically expressed in the floral buds of petunia hybrida. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10664841 |
Glasgow BJ et al. | Tear lipocalins: potential lipid scavengers for the corneal surface. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10586930 |
Sabourault C et al. | Tissue-specific induction and inactivation of cytochrome P450 catalysing lauric acid hydroxylation in the sea bass, Dicentrarchus labrax. | 1999 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10327614 |
Yamazaki H and Shimada T | Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. | 1999 | Xenobiotica | pmid:10219964 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Temme EH et al. | Effects of diets enriched in lauric, palmitic or oleic acids on blood coagulation and fibrinolysis. | 1999 | Thromb. Haemost. | pmid:10064003 |
Robinson MK et al. | A two-center study of the development of acute irritation responses to fatty acids. | 1999 | Am. J. Contact Dermatitis | pmid:10444106 |
Crawford TO et al. | Abnormal fatty acid metabolism in childhood spinal muscular atrophy. | 1999 | Ann. Neurol. | pmid:10072048 |
Haining RL et al. | Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding. | 1999 | Biochemistry | pmid:10079071 |
Chang YT and Loew GH | Homology modeling and substrate binding study of human CYP4A11 enzyme. | 1999 | Proteins | pmid:10024026 |
Lagrost L et al. | Variations in serum cholesteryl ester transfer and phospholipid transfer activities in healthy women and men consuming diets enriched in lauric, palmitic or oleic acids. | 1999 | Atherosclerosis | pmid:10030391 |
Richieri GV et al. | Binding kinetics of engineered mutants provide insight about the pathway for entering and exiting the intestinal fatty acid binding protein. | 1999 | Biochemistry | pmid:10231541 |
Bardi L et al. | Esterase activity and release of ethyl esters of medium-chain fatty acids by Saccharomyces cerevisiae during anaerobic growth. | 1998 | Can. J. Microbiol. | pmid:10347863 |
Lindmark T et al. | Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435199 |
Sawaguchi T and Nishida H | Fatty liver in sudden infant death autopsies. | 1998 | Am J Forensic Med Pathol | pmid:9760100 |
Crespi CL et al. | Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection. | 1998 | Methods Mol. Biol. | pmid:14577226 |
Meyer JH et al. | Length of intestinal contact on nutrient-driven satiety. | 1998 | Am. J. Physiol. | pmid:9756564 |
Miura Y and Oda S | Oxidation of fatty acids by kidney microsomes of musk shrew (Suncus murinus). | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9530812 |
Amet Y et al. | P-450-dependent metabolism of lauric acid in alcoholic liver disease: comparison between rat liver and kidney microsomes. | 1998 | Alcohol. Clin. Exp. Res. | pmid:9581653 |
Oszi Z and Pethö G | Quantitative determination of polysorbate 20 in nasal pharmaceutical preparations by high-performance liquid chromatography. | 1998 | J Pharm Biomed Anal | pmid:9919973 |
Andersen Borge GI et al. | Fatty acid alpha-oxidation of tetradecylthioacetic acid and tetradecylthiopropionic acid in cucumber (Cucumis sativus). | 1998 | Biochim. Biophys. Acta | pmid:9795197 |
Orellana M et al. | Peroxisomal and microsomal fatty acid oxidation in liver of rats after chronic ethanol consumption. | 1998 | Gen. Pharmacol. | pmid:9809485 |
Kroetz DL et al. | Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. | 1998 | J. Biol. Chem. | pmid:9813074 |
Zheng YM et al. | Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1. | 1998 | Biochemistry | pmid:9737862 |
Tappenden KA et al. | Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats. | 1998 | Am. J. Clin. Nutr. | pmid:9665105 |
Ueda I and Suzuki A | Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferase. | 1998 | Biophys. J. | pmid:9675206 |
Samartsev VN et al. | Involvement of aspartate/glutamate antiporter in uncoupling effect of fatty acids in heart mitochondria. | 1998 | Biochemistry Mosc. | pmid:9632895 |
Macdonald ID et al. | Fatty acid-induced alteration of the porphyrin macrocycle of cytochrome P450 BM3. | 1998 | Biophys. J. | pmid:9635777 |
Lee Y et al. | Preparation of slightly hydrophobic heparin derivatives which can be used for solvent casting in polymeric formulation. | 1998 | Thromb. Res. | pmid:9840023 |
Noble MA et al. | Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. | 1998 | Biochemistry | pmid:9843385 |
Orellana M et al. | Modulation of peroxisomal and microsomal fatty acid oxidation by acetone. A comparative study between liver and kidney. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9972312 |
Amichot M et al. | Induction of cytochrome P450 activities in Drosophila melanogaster strains susceptible or resistant to insecticides. | 1998 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9972473 |