lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Albuminuria D000419 18 associated lipids
Vasculitis D014657 14 associated lipids
Atherosclerosis D050197 85 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Bird Diseases D001715 4 associated lipids
Obesity, Morbid D009767 8 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nephrosis, Lipoid D009402 2 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Vascular System Injuries D057772 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Magdalou J et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. 1988 Biochem. Pharmacol. pmid:2840913
Amet Y et al. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. 1995 Biochem. Pharmacol. pmid:8615855
Williams DE et al. Sex differences in cytochrome P-450 isozyme composition and activity in kidney microsomes of mature rainbow trout. 1986 Biochem. Pharmacol. pmid:3718543
Pons N et al. Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. 2003 Biochem. Pharmacol. pmid:12907239
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Sharma R et al. Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies. 1988 Biochem. Pharmacol. pmid:3355594
Past MR and Cook DE Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450. 1982 Biochem. Pharmacol. pmid:7150359
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Bains SK et al. Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid. 1985 Biochem. Pharmacol. pmid:3929789
Hornung B et al. Medium chain length fatty acids stimulate triacylglycerol synthesis in tissue culture cells. 1992 Biochem. Pharmacol. pmid:1739406
Knickle LC et al. The suppression of hepatic cytochrome P4504A mRNA mediated by the interferon inducer polyinosinic acid.polycytidylic acid. 1992 Biochem. Pharmacol. pmid:1380810
Rodríguez-Penas D et al. Aliskiren affects fatty-acid uptake and lipid-related genes in rodent and human cardiomyocytes. 2011 Biochem. Pharmacol. pmid:21640714
Sivapathasundaram S et al. A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. 2001 Biochem. Pharmacol. pmid:11585060
Amet Y et al. Cytochrome P450 4A and 2E1 expression in human kidney microsomes. 1997 Biochem. Pharmacol. pmid:9113097
Okita RT et al. Lauric acid hydroxylation in human liver and kidney cortex microsomes. 1979 Biochem. Pharmacol. pmid:533546
Hvattum E et al. Microsomal oxidation of dodecylthioacetic acid (a 3-thia fatty acid) in rat liver. 1991 Mar 15-Apr 1 Biochem. Pharmacol. pmid:1672593
Kocarek TA and Feller DR Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes. 1989 Biochem. Pharmacol. pmid:2597188
Kitagawa S et al. Effects of alkyl gallates on P-glycoprotein function. 2005 Biochem. Pharmacol. pmid:16139251
Pham MA et al. Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. 1989 Biochem. Pharmacol. pmid:2500129
Raza H and Levine WG Effect of hypolipidemic drugs on the metabolism of lauric acid and dimethylaminoazobenzene by rat liver microsomes. 1987 Biochem. Pharmacol. pmid:3103631