lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Acne Vulgaris D000152 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Albuminuria D000419 18 associated lipids
Vasculitis D014657 14 associated lipids
Atherosclerosis D050197 85 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Bird Diseases D001715 4 associated lipids
Obesity, Morbid D009767 8 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nephrosis, Lipoid D009402 2 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Vascular System Injuries D057772 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Authors Title Published Journal PubMed Link
Yamasaki M et al. A kinetic and thermodynamic study on hydrolysis of sodium laurate in aqueous phase accompanied by transfer into oil phases containing different organic additives (I). 2005 Colloids Surf B Biointerfaces pmid:16202572
Krzan M et al. Effect of products of PLA2 catalyzed hydrolysis of DLPC on motion of rising bubbles. 2015 Colloids Surf B Biointerfaces pmid:25724770
Zhao L et al. Surface functionalization of titanium substrates with chitosan-lauric acid conjugate to enhance osteoblasts functions and inhibit bacteria adhesion. 2014 Colloids Surf B Biointerfaces pmid:24880988
Shelma R and Sharma CP Development of lauroyl sulfated chitosan for enhancing hemocompatibility of chitosan. 2011 Colloids Surf B Biointerfaces pmid:21367586
James-Smith MA et al. Effect of chain length on binding of fatty acids to Pluronics in microemulsions. 2008 Colloids Surf B Biointerfaces pmid:18155450
Marciello M et al. Full enzymatic hydrolysis of commercial sucrose laurate by immobilized-stabilized derivatives of lipase from Thermomyces lanuginosa. 2011 Colloids Surf B Biointerfaces pmid:21382701
Osthoff G et al. Milk composition of three free-ranging African elephant (Loxodonta africana africana) cows during mid lactation. 2007 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:17618152
Takaichi S et al. Fatty acids of astaxanthin esters in krill determined by mild mass spectrometry. 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:14529757
Miura Y and Oda S Oxidation of fatty acids by kidney microsomes of musk shrew (Suncus murinus). 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9530812
Sabourault C et al. Tissue-specific induction and inactivation of cytochrome P450 catalysing lauric acid hydroxylation in the sea bass, Dicentrarchus labrax. 1999 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:10327614
Orellana M et al. Modulation of peroxisomal and microsomal fatty acid oxidation by acetone. A comparative study between liver and kidney. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9972312
Orellana B M et al. Oxidative stress, microsomal and peroxisomal fatty acid oxidation in the liver of rats treated with acetone. 2001 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11301292
Wang-Buhler JL et al. CYP2K6 from zebrafish (Danio rerio): cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme. 2005 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:15907766
Ngo S et al. Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver. 2000 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11246504
Miller RR et al. Ethanol- and nicotine-induced membrane changes in embryonic and neonatal chick brains. 2001 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11574286
Orellana M et al. Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption. 2002 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:11879783
Orellana M et al. Modulation of cytochrome P450 activity in the kidney of rats following long-term red wine exposure. 2002 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:12161174
Ngo SN et al. The effects of Eucalyptus terpenes on hepatic cytochrome P450 CYP4A, peroxisomal Acyl CoA oxidase (AOX) and peroxisome proliferator activated receptor alpha (PPARalpha) in the common brush tail possum (Trichosurus vulpecula). 2003 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:14559298
Miura Y Seasonal change and sex difference in laurate hydroxylase activity in frog liver microsomes. 1985 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2865076
Takahashi N et al. Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. 1995 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:7599976
Amichot M et al. Induction of cytochrome P450 activities in Drosophila melanogaster strains susceptible or resistant to insecticides. 1998 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:9972473
Katoh K et al. Saturated fatty acids suppress adrenocorticotropic hormone (ACTH) release from rat anterior pituitary cells in vitro. 2004 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:15123208
Sharma A and Chauhan RS In silico identification and comparative genomics of candidate genes involved in biosynthesis and accumulation of seed oil in plants. 2012 Comp. Funct. Genomics pmid:22312320
Hirata-Koizumi M et al. Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats. 2009 Congenit Anom (Kyoto) pmid:20021483
Graham SA Cuphea: a new plant source of medium-chain fatty acids. 1989 Crit Rev Food Sci Nutr pmid:2653730
Bosnjak Z Personal narrative of prof. Zeljko Bosnjak, Laureate of Croatian National Decoration for Humanitarian Work. 2006 Croat. Med. J. pmid:17175606
Eldar R Personal narrative of prof. Reuben Eldar, Laureate of Croatian National Decoration for Humanitarian Work. 2006 Croat. Med. J. pmid:17175605
Siri-Tarino PW et al. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. 2010 Curr Atheroscler Rep pmid:20711693
Degorce F et al. HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications. 2009 Curr Chem Genomics pmid:20161833
Shacklett BL and Anton PA HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention. 2010 Curr Infect Dis Rep pmid:20174448
Slabu I et al. Investigation of superparamagnetic iron oxide nanoparticles for MR-visualization of surgical implants. 2012 Curr Pharm Biotechnol pmid:22214499
Mo SL et al. Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6. 2009 Curr. Drug Metab. pmid:19702527
Albers-Jackson B et al. Incorporation of 14C acetate into the phospholipids and fatty acids of rabbit lens in organ culture. 1982-1983 Curr. Eye Res. pmid:7184702
Hu F et al. Site-directed mutagenesis of Aeromonas hydrophila enoyl coenzyme A hydratase enhancing 3-hydroxyhexanoate fractions of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). 2007 Curr. Microbiol. pmid:17534562
Fibach E et al. Flow cytofluorometric analysis of the uptake of the fluorescent fatty acid pyrene-dodecanoic acid by human peripheral blood cells. 1988 Cytometry pmid:3208618
Malin-Berdel J and Valet G Flow cytometric determination of esterase and phosphatase activities and kinetics in hematopoietic cells with fluorogenic substrates. 1980 Cytometry pmid:6266787
Shaffer KK et al. Allergenicity and cross-reactivity of coconut oil derivatives: A double-blind randomized controlled pilot study. 2006 Dermatitis pmid:16956456
Tabatabai LB and Deyoe BL Biochemical and biological properties of soluble protein preparations from Brucella abortus. 1984 Dev. Biol. Stand. pmid:6436094
Tan CP et al. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. 2008 Diabetes pmid:18477808
Yeop Han C et al. Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. 2010 Diabetes pmid:19934003
Iaconelli A et al. Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes. 2010 Diabetes Care pmid:20724647
Ma J et al. A randomised trial of enteric-coated nutrient pellets to stimulate gastrointestinal peptide release and lower glycaemia in type 2 diabetes. 2013 Diabetologia pmid:23471488
Vessey DA Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine. 2001 Dig. Dis. Sci. pmid:11281196
Fernandes R et al. Relationship between acute phase proteins and serum fatty acid composition in morbidly obese patients. 2013 Dis. Markers pmid:24167354
Bogdanova LR et al. Micellar catalytic effect as a factor of lipase activity regulation. 2012 Sep-Oct Dokl. Biochem. Biophys. pmid:23132718
Pazo JA and Parafita MA Synergism of ethanol and clofibrate in the lauric acid hydroxylation. 1988 Drug Alcohol Depend pmid:3416732
Kemper RA and Nabb DL In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases. 2005 Drug Chem Toxicol pmid:16051554
Hirata-Koizumi M et al. Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity. 2009 Drug Chem Toxicol pmid:19538016
Mushtaq M et al. Toxicological studies of a leachable stabilizer di-n-butyltin dilaurate(DBTL): effects on hepatic drug metabolizing enzyme activities. 1981 Drug Chem Toxicol pmid:7261948
Joo HH et al. In vitro permeation study of hinokitiol: effects of vehicles and enhancers. 2008 Drug Deliv pmid:18197519
Mahdi ES et al. Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. 2011 Drug Des Devel Ther pmid:21792294
Hickey AJ and Byron PR Effect of a non-hygroscopic surfactant coating upon fluorescein absorption from the respiratory tract. 1987 Drug Des. Deliv. pmid:3509343
Funke AP et al. Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen. 2003 Drug Dev Ind Pharm pmid:12906336
An NM et al. Development of a novel soft hydrogel for the transdermal delivery of testosterone. 2003 Drug Dev Ind Pharm pmid:12602497
Jung SY et al. Formulation and evaluation of ubidecarenone transdermal delivery systems. 2009 Drug Dev Ind Pharm pmid:19365779
Soler LI et al. Transdermal delivery of alprazolam from a monolithic patch: formulation based on in vitro characterization. 2012 Drug Dev Ind Pharm pmid:22204649
Hossain MA et al. Effect of vehicle systems, pH and enhancers on the permeation of highly lipophilic aripiprazole from Carbopol 971P gel systems across human cadaver skin. 2012 Drug Dev Ind Pharm pmid:22067044
Chisty MN et al. In vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranes. 2002 Drug Dev Ind Pharm pmid:12476868
Abu-Huwaij R et al. Potential mucoadhesive dosage form of lidocaine hydrochloride: II. In vitro and in vivo evaluation. 2007 Drug Dev Ind Pharm pmid:17523008
Pattnaik S et al. Influence of chemical permeation enhancers on transdermal permeation of alfuzosin: an investigation using response surface modeling. 2011 Drug Dev Ind Pharm pmid:21446831
Cho YA and Gwak HS Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. 2004 Drug Dev Ind Pharm pmid:15285328
Minn AL et al. Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. 2005 Drug Metab. Dispos. pmid:15879494
Pan J et al. Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice. 2003 Drug Metab. Dispos. pmid:12642464
Ozalp C et al. Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells. 2005 Drug Metab. Dispos. pmid:15980100
Graham RA et al. In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs. 2002 Drug Metab. Dispos. pmid:12386126
Castle PJ et al. Human liver lauric acid hydroxylase activities. 1995 Drug Metab. Dispos. pmid:8654190
Yang YH et al. Heterologous expression of CYP2K1 and identification of the expressed protein (BV-CYP2K1) as lauric acid (omega-1)-hydroxylase and aflatoxin B1 exo-epoxidase. 2000 Drug Metab. Dispos. pmid:11038153
Poloyac SM et al. The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. 2004 Drug Metab. Dispos. pmid:15205388
Buhler DR et al. The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450s. 1997 Drug Metab. Dispos. pmid:9321521
Grillo MP and Lohr MT Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes. 2009 Drug Metab. Dispos. pmid:19196839
Grillo MP et al. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. 2010 Drug Metab. Dispos. pmid:19786506
Li C et al. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. 2003 Drug Metab. Dispos. pmid:12756204
Albro PW et al. In vitro metabolism of mono-2-ethylhexyl phthalate by microsomal enzymes. Similarity to omega- and (omega-1) oxidation of fatty acids. 1984 Nov-Dec Drug Metab. Dispos. pmid:6150824
Okita RT and Masters BS Effect of phenobarbital treatment and cytochrome P-450 inhibitors on the laurate omega- and (omega - 1)-hydroxylase activities of rat liver microsomes. 1980 May-Jun Drug Metab. Dispos. pmid:6104577
Dell HD et al. Etofenamate fatty acid asters. An example of a new route of drug metabolism. 1982 Jan-Feb Drug Metab. Dispos. pmid:6124384
Orton TC and Parker GL The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid. 1982 Mar-Apr Drug Metab. Dispos. pmid:6124394
Raza H and Levine WG Azoreduction of N,N-dimethyl-4-aminoazobenzene (DAB) by rat hepatic microsomes. Selective induction by clofibrate. 1986 Jan-Feb Drug Metab. Dispos. pmid:2868860
Levine WG and Raza H Mechanism of azoreduction of dimethylaminoazobenzene by rat liver NADPH-cytochrome P-450 reductase and partially purified cytochrome P-450. Oxygen and carbon monoxide sensitivity and stimulation by FAD and FMN. 1988 May-Jun Drug Metab. Dispos. pmid:2900738
Yamaura Y et al. Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions. 2011 Drug Metab. Pharmacokinet. pmid:21422671
Hayashi S et al. Essential role of singlet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes. 2005 Drug Metab. Pharmacokinet. pmid:15770071
Yasui H et al. Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations. 2002 Drug Metab. Pharmacokinet. pmid:15618693
Yamazaki H et al. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. 2002 Drug Metab. Pharmacokinet. pmid:15618652
Parkinson A et al. On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice. 2006 Drug Metab. Rev. pmid:16684660
Imai Y et al. Structure-function relationships of cytochrome P-450 laurate (omega-1)-hydroxylase. 1989 Drug Metab. Rev. pmid:2680391
Noble MA et al. Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains. 2007 Drug Metab. Rev. pmid:17786641
Miko M and Devínsky F Biochemical basis of cytotoxic activity of some new N'-oxides of N',N'-dimethylaminoalkylamides of dodecanoic acid. 1992 Drug Metabol Drug Interact pmid:1424644
Otomo S et al. Prostaglandin E1 incorporated in lipid microspheres (lipo PGE1). 1985 Drugs Exp Clin Res pmid:3880049
Goto J et al. A comparison of the effect of Lipo PGE1 and other related compounds on experimental peripheral arterial occlusive disease in rats. 1986 Drugs Exp Clin Res pmid:3816509
Wikström M [Nobel prize laureate in chemistry]. 1978 Duodecim pmid:729494
Cao J et al. Evaluation of the addition of various surfactant-suspended carbon nanotubes in MEEKC with an in situ-synthesized surfactant system. 2011 Electrophoresis pmid:21254135
Petersson P et al. Direct coupling of micellar electrokinetic chromatography to mass spectrometry using a volatile buffer system based on perfluorooctanoic acid and ammonia. 2003 Electrophoresis pmid:12658688
The Endocrine Society 2009 Laureate Awards. 2009 Endocr. Rev. pmid:19663077
The Endocrine Society Laureate Awards. 2009 Endocr. Rev. pmid:19663075
The Endocrine Society 2012 Laureate Awards. 2012 Endocr. Rev. pmid:23038815
The Endocrine Society Laureate Awards. 2012 Endocr. Rev. pmid:23038814
The Endocrine Society 2007 Laureate Awards. 2007 Endocr. Rev. pmid:17722366
The Endocrine Society Laureate Awards. 2007 Endocr. Rev. pmid:17722365
The Endocrine Society 2011 Laureate Awards. 2011 Endocr. Rev. pmid:21932463
The Endocrine Society Laureate Awards. 2011 Endocr. Rev. pmid:21932462
Kopp A et al. C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue. 2010 Endocrinology pmid:20739398