lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

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Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Obesity, Morbid D009767 8 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Seizures D012640 87 associated lipids
Starvation D013217 47 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Thrombosis D013927 49 associated lipids
Vasculitis D014657 14 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Brain Infarction D020520 17 associated lipids
Stroke D020521 32 associated lipids
Atherosclerosis D050197 85 associated lipids
Vascular System Injuries D057772 2 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

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Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Imamura T et al. Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. 2003 Arzneimittelforschung pmid:14650360
Idris CA and Sundram K Effect of dietary cholesterol, trans and saturated fatty acids on serum lipoproteins in non-human primates. 2002 Asia Pac J Clin Nutr pmid:12492627
Serra I et al. Effect of dietary intake on the levels of biliary unsaturated free Fatty acids having inhibitory activity on mutagens. 2009 Asian Pac. J. Cancer Prev. pmid:20104986
Hanley K et al. Development of a plant viral-vector-based gene expression assay for the screening of yeast cytochrome p450 monooxygenases. 2003 Assay Drug Dev Technol pmid:15090141
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Yoshida H et al. A phosphodiesterase 3 inhibitor, K-134, improves hindlimb skeletal muscle circulation in rat models of peripheral arterial disease. 2012 Atherosclerosis pmid:22269153
Arrol S et al. The effects of fatty acids on apolipoprotein B secretion by human hepatoma cells (HEP G2). 2000 Atherosclerosis pmid:10856517
Redgrave TG and Dunne KB Chylomicron formation and composition in unanaesthetised rabbits. 1975 Nov-Dec Atherosclerosis pmid:173354
Lagrost L et al. Variations in serum cholesteryl ester transfer and phospholipid transfer activities in healthy women and men consuming diets enriched in lauric, palmitic or oleic acids. 1999 Atherosclerosis pmid:10030391
Timbermont L et al. Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. 2010 Avian Pathol. pmid:20390546
Alves NF et al. Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. 2017 Basic Clin. Pharmacol. Toxicol. pmid:28054477
Stark K et al. Expression of CYP4F12 in gastrointestinal and urogenital epithelia. 2004 Basic Clin. Pharmacol. Toxicol. pmid:15078342
Russell VA et al. Animal models of attention-deficit hyperactivity disorder. 2005 Behav Brain Funct pmid:16022733
Bambal RB and Hanzlik RP Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. 1996 Biochem. Biophys. Res. Commun. pmid:8605007
Imaoka S and Funae Y Purification and NH2-terminal sequence of cytochrome P-450 from kidney microsomes of untreated male rats. 1986 Biochem. Biophys. Res. Commun. pmid:3801020
Leighton F et al. Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6732769
Okita R and Chance C Induction of laurate omega-hydroxylase by di (2-ethylhexyl)phthalate in rat liver microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732809
Han S et al. Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. 2017 Biochem. Biophys. Res. Commun. pmid:27890614
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Imai Y and Nakamura M Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). 1989 Biochem. Biophys. Res. Commun. pmid:2493247