| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipidemias | D006949 | 73 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Vasculitis | D014657 | 14 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Thromboangiitis Obliterans | D013919 | 4 associated lipids |
| Bird Diseases | D001715 | 4 associated lipids |
| Obesity, Morbid | D009767 | 8 associated lipids |
| Cell Transformation, Viral | D002472 | 26 associated lipids |
lauric acid
lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
Cross Reference
Introduction
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lauric acid?
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lauric acid
PubChem Associated disorders and diseases
What pathways are associated with lauric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lauric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with lauric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lauric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with lauric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lauric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with lauric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bardi L et al. | Esterase activity and release of ethyl esters of medium-chain fatty acids by Saccharomyces cerevisiae during anaerobic growth. | 1998 | Can. J. Microbiol. | pmid:10347863 |
| Lindmark T et al. | Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435199 |
| Kroetz DL et al. | Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. | 1998 | J. Biol. Chem. | pmid:9813074 |
| Zheng YM et al. | Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1. | 1998 | Biochemistry | pmid:9737862 |
| Sigalet DL et al. | Determination of the route of medium-chain and long-chain fatty acid absorption by direct measurement in the rat. | 1997 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:9323689 |
| Chevalier G et al. | Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol. | 1997 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:9179563 |
| Maves SA et al. | Decreased substrate affinity upon alteration of the substrate-docking region in cytochrome P450(BM-3). | 1997 | FEBS Lett. | pmid:9315688 |
| Buhler DR et al. | The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450s. | 1997 | Drug Metab. Dispos. | pmid:9321521 |
| Wiberg E et al. | Fatty acid distribution and lipid metabolism in developing seeds of laurate-producing rape (Brassica napus L.). | 1997 | Planta | pmid:9431681 |
| Kroetz DL et al. | Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. | 1997 | Mol. Pharmacol. | pmid:9281597 |
| Winkelaar GB et al. | Fat absorption after small intestinal transplantation in the rat. | 1997 | Transplantation | pmid:9293866 |
| Murataliev MB et al. | Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. | 1997 | Biochemistry | pmid:9204888 |
| Orellana M et al. | Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver. | 1997 | Gen. Pharmacol. | pmid:9068973 |
| Amet Y et al. | Cytochrome P450 4A and 2E1 expression in human kidney microsomes. | 1997 | Biochem. Pharmacol. | pmid:9113097 |
| Khosla P et al. | Decreasing dietary lauric and myristic acids improves plasma lipids more favorably than decreasing dietary palmitic acid in rhesus monkeys fed AHA step 1 type diets. | 1997 | J. Nutr. | pmid:9082040 |
| Orellana M et al. | Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: a comparative study between liver and kidney. | 1997 | Gen. Pharmacol. | pmid:9147020 |
| Clementz T et al. | Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. | 1997 | J. Biol. Chem. | pmid:9099672 |
| Lu P et al. | Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. | 1997 | Arch. Biochem. Biophys. | pmid:8990261 |
| Winkler E et al. | Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue. | 1997 | Biochemistry | pmid:8993328 |
| Helvig C et al. | Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase. | 1997 | J. Biol. Chem. | pmid:8995277 |
| Imaoka S et al. | Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. | 1997 | Biochem. Pharmacol. | pmid:9310344 |
| Crespi CL and Miller VP | The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase. | 1997 | Pharmacogenetics | pmid:9241660 |
| Djelouah I et al. | Fat embolism in orthopedic surgery: role of bone marrow fatty acid. | 1997 | Anesth. Analg. | pmid:9249128 |
| Poli-Scaife S et al. | The substrate binding site of human liver cytochrome P450 2C9: an NMR study. | 1997 | Biochemistry | pmid:9335524 |
| Sunshine MG et al. | Mutation of the htrB gene in a virulent Salmonella typhimurium strain by intergeneric transduction: strain construction and phenotypic characterization. | 1997 | J. Bacteriol. | pmid:9287009 |
| Temme EH et al. | Comparison of the effects of diets enriched in lauric, palmitic, or oleic acids on serum lipids and lipoproteins in healthy women and men. | 1996 | Am. J. Clin. Nutr. | pmid:8644684 |
| Bambal RB and Hanzlik RP | Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8605007 |
| Hiratsuka M et al. | Effects of gonadectomy and sex hormones on the induction of hepatic CYP4A by clofibrate in rats. | 1996 | Biol. Pharm. Bull. | pmid:8820907 |
| Kacáni L et al. | Immunomodulatory effect of some amphiphilic detergents on the human promyelocytic HL-60 cells. | 1996 | Folia Biol. (Praha) | pmid:8831021 |
| Amet Y et al. | Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8811432 |
| Tanaka K et al. | Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. | 1996 | Biochim. Biophys. Acta | pmid:8765103 |
| Shet Ms et al. | The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. | 1996 | Arch. Biochem. Biophys. | pmid:8651697 |
| Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
| Parrish JM et al. | Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. | 1996 | Toxicology | pmid:8658551 |
| Clementz T et al. | Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. | 1996 | J. Biol. Chem. | pmid:8662613 |
| Byard J et al. | Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. | 1996 | Biochem. Soc. Trans. | pmid:8736866 |
| Bekkers AC et al. | Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification. | 1996 | Eur. J. Biochem. | pmid:8665954 |
| Roberts GC | The other kind of biological NMR--studies of enzyme-substrate interactions. | 1996 | Neurochem. Res. | pmid:8897475 |
| Winkler GB et al. | Fat absorption following small intestinal transplantation. | 1996 | Transplant. Proc. | pmid:8907942 |
| Constantinides PP et al. | Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. | 1996 | Pharm. Res. | pmid:8932438 |
| Kemp PM et al. | Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency. | 1996 | Am J Forensic Med Pathol | pmid:8838477 |
| Murataliev MB and Feyereisen R | Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. | 1996 | Biochemistry | pmid:8942669 |
| Ross KF et al. | Comment on "Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency". | 1996 | Am J Forensic Med Pathol | pmid:8947364 |
| Hiratsuka M et al. | Sex differences in constitutive level of renal lauric acid hydroxylase activities and CYP4A-related proteins in mice. | 1996 | Biol. Pharm. Bull. | pmid:8860949 |
| Wang MH et al. | Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. | 1996 | Arch. Biochem. Biophys. | pmid:8954571 |
| Charbon V et al. | Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs. | 1996 | Pharm. Res. | pmid:8668674 |
| Kinderlerer JL et al. | Effect of medium-chain fatty acids in mould ripened cheese on the growth of Listeria monocytogenes. | 1996 | J. Dairy Res. | pmid:8933308 |
| Kragh-Hansen U et al. | High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. | 1996 | Biochem. J. | pmid:9003380 |
| Powell PK et al. | Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8914854 |
| Vickers AE et al. | Hydroxyethyl cyclosporin A induces and decreases P4503A and P-glycoprotein levels in rat liver. | 1996 | Xenobiotica | pmid:8851819 |
| Bookstaff RC et al. | Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8975784 |
| Petschow BW et al. | Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. | 1996 | Antimicrob. Agents Chemother. | pmid:8834870 |
| Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
| Motoyama Y et al. | Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on a peripheral arterial occlusive disease model in rats. | 1995 | Prostaglandins | pmid:7652186 |
| Smith SW and Anderson BD | Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions. | 1995 | J Pharm Sci | pmid:7658343 |
| Kromhout D et al. | Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. | 1995 | Prev Med | pmid:7644455 |
| Faulkner KM et al. | Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7644480 |
| Pronczuk A et al. | Plasma lipids are affected similarly by dietary lauric or palmitic acid in gerbils and monkeys. | 1995 | Lipids | pmid:8614307 |
| Amet Y et al. | Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. | 1995 | Biochem. Pharmacol. | pmid:8615855 |
| Saito M et al. | 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8788145 |
| Castle PJ et al. | Human liver lauric acid hydroxylase activities. | 1995 | Drug Metab. Dispos. | pmid:8654190 |
| Valdes E et al. | Dietary fish oil and cytochrome P-450 monooxygenase activity in rat liver and kidney. | 1995 | Lipids | pmid:8538384 |
| Lapshina EA et al. | Effect of free fatty acids on the structure and properties of erythrocyte membrane. | 1995 | Scand. J. Clin. Lab. Invest. | pmid:8545597 |
| Niederprüm HJ et al. | Inhibition of steroid 5 alpha-reductase activity by aliphatic fatty acids. Candidates for chemoprevention of prostate cancer. | 1995 | Ann. N. Y. Acad. Sci. | pmid:8526353 |
| Lee SK et al. | Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. | 1995 | Pancreas | pmid:7479681 |
| Komata Y et al. | Accumulation of lauric acid in skin as an enhancer for the percutaneous absorption of thiamine disulfide. | 1995 | Biol. Pharm. Bull. | pmid:7493004 |
| Modi S et al. | NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. | 1995 | Biochemistry | pmid:7619797 |
| Alterman MA et al. | Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575514 |
| Yeom H et al. | The role of Thr268 in oxygen activation of cytochrome P450BM-3. | 1995 | Biochemistry | pmid:7578081 |
| Iwami Y et al. | Effect of sucrose monolaurate on acid production, levels of glycolytic intermediates, and enzyme activities of Streptococcus mutans NCTC 10449. | 1995 | J. Dent. Res. | pmid:7560425 |
| Tholstrup T et al. | Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men. | 1995 | J. Lipid Res. | pmid:7595068 |
| Knauf VC and Facciotti D | Genetic engineering of foods to reduce the risk of heart disease and cancer. | 1995 | Adv. Exp. Med. Biol. | pmid:7598011 |
| Takahashi N et al. | Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:7599976 |
| Pedersen AO et al. | Effects of ionic strength and pH on the binding of medium-chain fatty acids to human serum albumin. | 1995 | Eur. J. Biochem. | pmid:7588780 |
| Redondo O et al. | Comparative kinetic study of lipases A and B from Candida rugosa in the hydrolysis of lipid p-nitrophenyl esters in mixed micelles with Triton X-100. | 1995 | Biochim. Biophys. Acta | pmid:7827103 |
| Ramarao MK et al. | Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1. | 1995 | J. Biol. Chem. | pmid:7829524 |
| Hermansen JE | Prediction of milk fatty acid profile in dairy cows fed dietary fat differing in fatty acid composition. | 1995 | J. Dairy Sci. | pmid:7790578 |
| Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
| Godet MC et al. | Inclusion/exclusion of fatty acids in amylose complexes as a function of the fatty acid chain length. | 1995 | Int. J. Biol. Macromol. | pmid:8789347 |
| Geissdörfer W et al. | Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1. | 1995 | Microbiology (Reading, Engl.) | pmid:7670642 |
| Chaurasia CS et al. | Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. | 1995 | Arch. Biochem. Biophys. | pmid:7872779 |
| Schwab US et al. | Lauric and palmitic acid-enriched diets have minimal impact on serum lipid and lipoprotein concentrations and glucose metabolism in healthy young women. | 1995 | J. Nutr. | pmid:7876922 |
| Lee CK et al. | Transdermal delivery of theophylline using an ethanol/panasate 800-ethylcellulose gel preparation. | 1995 | Biol. Pharm. Bull. | pmid:7735237 |
| Preobrazhenskaia TA et al. | [Comparative effect of polymyxin B on lipid bilayer membranes with different lipid composition]. | 1994 Nov-Dec | Biofizika | pmid:7873621 |
| Clarke SE et al. | Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. | 1994 Nov-Dec | Chem. Res. Toxicol. | pmid:7696540 |
| Shirakura S et al. | Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs. | 1994 | Jpn. J. Pharmacol. | pmid:7967232 |
| Mohan S and Raetz CR | Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate. | 1994 | J. Bacteriol. | pmid:7961456 |
| Lee CK et al. | Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system. | 1994 | Biol. Pharm. Bull. | pmid:7874070 |
| Komata Y et al. | Effect of fatty acid on the accumulation of thiamine disulfide in rat skin. | 1994 | Biol. Pharm. Bull. | pmid:7920438 |
| Amet Y et al. | Evidence that cytochrome P450 2E1 is involved in the (omega-1)-hydroxylation of lauric acid in rat liver microsomes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8093035 |
| Duncan T et al. | A glycoprotein binding retinoids and fatty acids is present in Drosophila. | 1994 | Arch. Biochem. Biophys. | pmid:8031123 |
| Mirsky VM | Effect of the lipid hydrolysis products on the phospholipase A2 action towards lipid monolayer. | 1994 | Chem. Phys. Lipids | pmid:8013058 |
| Grundy SM | Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977157 |
| Nakamura M et al. | Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A. | 1994 | Biochem. Pharmacol. | pmid:7980643 |
| Hornung B et al. | Lauric acid inhibits the maturation of vesicular stomatitis virus. | 1994 | J. Gen. Virol. | pmid:8113756 |
| Hayes ML | Reduction in acid tolerance of Streptococcus downeii by fluoride and potassium laurate. | 1994 | Caries Res. | pmid:8156568 |
| Kubo I et al. | Naturally occurring antiacne agents. | 1994 | J. Nat. Prod. | pmid:8158169 |
| Pinot F et al. | New cytochrome P450-dependent reactions from wheat: terminal and sub-terminal hydroxylation of oleic acid by microsomes from naphthalic acid anhydride and phenobarbital induced wheat seedlings. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297392 |
| Tholstrup T et al. | Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. | 1994 | Am. J. Clin. Nutr. | pmid:8310987 |
| Mensink RP et al. | Dietary saturated and trans fatty acids and lipoprotein metabolism. | 1994 | Ann. Med. | pmid:7695873 |