lauric acid

lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.

Cross Reference

Introduction

To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with lauric acid?

lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with lauric acid

MeSH term MeSH ID Detail
Hyperlipidemias D006949 73 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Albuminuria D000419 18 associated lipids
Vasculitis D014657 14 associated lipids
Atherosclerosis D050197 85 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Thromboangiitis Obliterans D013919 4 associated lipids
Bird Diseases D001715 4 associated lipids
Obesity, Morbid D009767 8 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Per page 10 20 50 | Total 33

PubChem Associated disorders and diseases

What pathways are associated with lauric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with lauric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with lauric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with lauric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with lauric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with lauric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with lauric acid

Download all related citations
Per page 10 20 50 100 | Total 1837
Authors Title Published Journal PubMed Link
Valdes E et al. Dietary fish oil and cytochrome P-450 monooxygenase activity in rat liver and kidney. 1995 Lipids pmid:8538384
Lapshina EA et al. Effect of free fatty acids on the structure and properties of erythrocyte membrane. 1995 Scand. J. Clin. Lab. Invest. pmid:8545597
Mabrey S and Sturtevant JM Incorporation of saturated fatty acids into phosphatidylcholine bilayers. 1977 Biochim. Biophys. Acta pmid:856286
Bambal RB and Hanzlik RP Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. 1996 Biochem. Biophys. Res. Commun. pmid:8605007
Pronczuk A et al. Plasma lipids are affected similarly by dietary lauric or palmitic acid in gerbils and monkeys. 1995 Lipids pmid:8614307
Amet Y et al. Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. 1995 Biochem. Pharmacol. pmid:8615855
Temme EH et al. Comparison of the effects of diets enriched in lauric, palmitic, or oleic acids on serum lipids and lipoproteins in healthy women and men. 1996 Am. J. Clin. Nutr. pmid:8644684
Shet Ms et al. The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. 1996 Arch. Biochem. Biophys. pmid:8651697
Narayanan VS and Storch J Fatty acid transfer in taurodeoxycholate mixed micelles. 1996 Biochemistry pmid:8652524
Castle PJ et al. Human liver lauric acid hydroxylase activities. 1995 Drug Metab. Dispos. pmid:8654190
Parrish JM et al. Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. 1996 Toxicology pmid:8658551
Clementz T et al. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. 1996 J. Biol. Chem. pmid:8662613
Bekkers AC et al. Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification. 1996 Eur. J. Biochem. pmid:8665954
Charbon V et al. Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs. 1996 Pharm. Res. pmid:8668674
Sherrington EJ et al. Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. 1996 Biochem. Soc. Trans. pmid:8736816
Byard J et al. Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. 1996 Biochem. Soc. Trans. pmid:8736866
von Wichert P et al. Increased incorporation of fatty acids into phospholipids of lungs and livers of rabbits under the influence of bromhexine and ambroxol. 1977 Naunyn Schmiedebergs Arch. Pharmacol. pmid:876401
Tanaka K et al. Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. 1996 Biochim. Biophys. Acta pmid:8765103
Saito M et al. 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum. 1995 J. Chromatogr. B, Biomed. Appl. pmid:8788145
Godet MC et al. Inclusion/exclusion of fatty acids in amylose complexes as a function of the fatty acid chain length. 1995 Int. J. Biol. Macromol. pmid:8789347
Amet Y et al. Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes. 1996 J. Chromatogr. B, Biomed. Appl. pmid:8811432
Hiratsuka M et al. Effects of gonadectomy and sex hormones on the induction of hepatic CYP4A by clofibrate in rats. 1996 Biol. Pharm. Bull. pmid:8820907
Kacáni L et al. Immunomodulatory effect of some amphiphilic detergents on the human promyelocytic HL-60 cells. 1996 Folia Biol. (Praha) pmid:8831021
Petschow BW et al. Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. 1996 Antimicrob. Agents Chemother. pmid:8834870
Kemp PM et al. Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency. 1996 Am J Forensic Med Pathol pmid:8838477
Vickers AE et al. Hydroxyethyl cyclosporin A induces and decreases P4503A and P-glycoprotein levels in rat liver. 1996 Xenobiotica pmid:8851819
Hiratsuka M et al. Sex differences in constitutive level of renal lauric acid hydroxylase activities and CYP4A-related proteins in mice. 1996 Biol. Pharm. Bull. pmid:8860949
Roberts GC The other kind of biological NMR--studies of enzyme-substrate interactions. 1996 Neurochem. Res. pmid:8897475
Winkler GB et al. Fat absorption following small intestinal transplantation. 1996 Transplant. Proc. pmid:8907942
Powell PK et al. Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8914854
Constantinides PP et al. Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. 1996 Pharm. Res. pmid:8932438
George GM et al. Atomic absorption spectrophotometric determination of dibutyltin dilaurate in finished feeds: collaborative study. 1977 J Assoc Off Anal Chem pmid:893325
Kinderlerer JL et al. Effect of medium-chain fatty acids in mould ripened cheese on the growth of Listeria monocytogenes. 1996 J. Dairy Res. pmid:8933308
Murataliev MB and Feyereisen R Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. 1996 Biochemistry pmid:8942669
Ross KF et al. Comment on "Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency". 1996 Am J Forensic Med Pathol pmid:8947364
Wang MH et al. Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. 1996 Arch. Biochem. Biophys. pmid:8954571
Bookstaff RC et al. Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. 1996 Toxicol. Appl. Pharmacol. pmid:8975784
Lu P et al. Heme-coordinating analogs of lauric acid as inhibitors of fatty acid omega-hydroxylation. 1997 Arch. Biochem. Biophys. pmid:8990261
Winkler E et al. Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue. 1997 Biochemistry pmid:8993328
Helvig C et al. Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase. 1997 J. Biol. Chem. pmid:8995277
Kragh-Hansen U et al. High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. 1996 Biochem. J. pmid:9003380
Orellana M et al. Microsomal and peroxisomal fatty acid oxidation in streptozotocin diabetic rat liver. 1997 Gen. Pharmacol. pmid:9068973
Khosla P et al. Decreasing dietary lauric and myristic acids improves plasma lipids more favorably than decreasing dietary palmitic acid in rhesus monkeys fed AHA step 1 type diets. 1997 J. Nutr. pmid:9082040
Clementz T et al. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. 1997 J. Biol. Chem. pmid:9099672
Amet Y et al. Cytochrome P450 4A and 2E1 expression in human kidney microsomes. 1997 Biochem. Pharmacol. pmid:9113097
Orellana M et al. Microsomal and peroxisomal fatty acid oxidation in bile duct ligated rats: a comparative study between liver and kidney. 1997 Gen. Pharmacol. pmid:9147020
Chevalier G et al. Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol. 1997 Jan-Mar Eur J Drug Metab Pharmacokinet pmid:9179563
Murataliev MB et al. Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain. 1997 Biochemistry pmid:9204888
Crespi CL and Miller VP The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase. 1997 Pharmacogenetics pmid:9241660
Djelouah I et al. Fat embolism in orthopedic surgery: role of bone marrow fatty acid. 1997 Anesth. Analg. pmid:9249128