MeSH term | MeSH ID | Detail |
---|---|---|
Atherosclerosis | D050197 | 85 associated lipids |
Vascular System Injuries | D057772 | 2 associated lipids |
Peripheral Arterial Disease | D058729 | 7 associated lipids |
lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hiratsuka M et al. | Effects of gonadectomy and sex hormones on the induction of hepatic CYP4A by clofibrate in rats. | 1996 | Biol. Pharm. Bull. | pmid:8820907 |
Kacáni L et al. | Immunomodulatory effect of some amphiphilic detergents on the human promyelocytic HL-60 cells. | 1996 | Folia Biol. (Praha) | pmid:8831021 |
Amet Y et al. | Simultaneous radiometric and fluorimetric detection of lauric acid metabolites using high-performance liquid chromatography following esterification with 4-bromomethyl-6,7-dimethoxycoumarin in human and rat liver microsomes. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8811432 |
Tanaka K et al. | Enhancement of intestinal transport of thyrotropin-releasing hormone via a carrier-mediated transport system by chemical modification with lauric acid. | 1996 | Biochim. Biophys. Acta | pmid:8765103 |
Shet Ms et al. | The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase. | 1996 | Arch. Biochem. Biophys. | pmid:8651697 |
Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
Parrish JM et al. | Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. | 1996 | Toxicology | pmid:8658551 |
Clementz T et al. | Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. | 1996 | J. Biol. Chem. | pmid:8662613 |
Byard J et al. | Novel approaches to the purification and identification of cytochrome P450 enzymes in the equine. | 1996 | Biochem. Soc. Trans. | pmid:8736866 |
Bekkers AC et al. | Targeting of porcine pancreatic phospholipase A2 to human platelets. Introduction of an RGD sequence and acyl-group by chemical modification. | 1996 | Eur. J. Biochem. | pmid:8665954 |
Roberts GC | The other kind of biological NMR--studies of enzyme-substrate interactions. | 1996 | Neurochem. Res. | pmid:8897475 |
Winkler GB et al. | Fat absorption following small intestinal transplantation. | 1996 | Transplant. Proc. | pmid:8907942 |
Constantinides PP et al. | Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation. | 1996 | Pharm. Res. | pmid:8932438 |
Kemp PM et al. | Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency. | 1996 | Am J Forensic Med Pathol | pmid:8838477 |
Murataliev MB and Feyereisen R | Functional interactions in cytochrome P450BM3. Fatty acid substrate binding alters electron-transfer properties of the flavoprotein domain. | 1996 | Biochemistry | pmid:8942669 |
Ross KF et al. | Comment on "Whole blood levels of dodecanoic acid, a routinely detectable forensic marker for a genetic disease often misdiagnosed as sudden infant death syndrome (SIDS): MCAD deficiency". | 1996 | Am J Forensic Med Pathol | pmid:8947364 |
Hiratsuka M et al. | Sex differences in constitutive level of renal lauric acid hydroxylase activities and CYP4A-related proteins in mice. | 1996 | Biol. Pharm. Bull. | pmid:8860949 |
Wang MH et al. | Cloning, sequencing, and cDNA-directed expression of the rat renal CYP4A2: arachidonic acid omega-hydroxylation and 11,12-epoxidation by CYP4A2 protein. | 1996 | Arch. Biochem. Biophys. | pmid:8954571 |
Charbon V et al. | Targeting of drug to the hepatocytes by fatty acids. Influence of the carrier (albumin or galactosylated albumin) on the fate of the fatty acids and their analogs. | 1996 | Pharm. Res. | pmid:8668674 |
Kinderlerer JL et al. | Effect of medium-chain fatty acids in mould ripened cheese on the growth of Listeria monocytogenes. | 1996 | J. Dairy Res. | pmid:8933308 |
Kragh-Hansen U et al. | High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin. | 1996 | Biochem. J. | pmid:9003380 |
Powell PK et al. | Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8914854 |
Vickers AE et al. | Hydroxyethyl cyclosporin A induces and decreases P4503A and P-glycoprotein levels in rat liver. | 1996 | Xenobiotica | pmid:8851819 |
Bookstaff RC et al. | Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8975784 |
Petschow BW et al. | Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids. | 1996 | Antimicrob. Agents Chemother. | pmid:8834870 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Motoyama Y et al. | Effect of TFC-612, a 7-thia prostaglandin E1 derivative, on a peripheral arterial occlusive disease model in rats. | 1995 | Prostaglandins | pmid:7652186 |
Smith SW and Anderson BD | Human skin permeability enhancement by lauric acid under equilibrium aqueous conditions. | 1995 | J Pharm Sci | pmid:7658343 |
Kromhout D et al. | Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. | 1995 | Prev Med | pmid:7644455 |
Faulkner KM et al. | Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7644480 |
Pronczuk A et al. | Plasma lipids are affected similarly by dietary lauric or palmitic acid in gerbils and monkeys. | 1995 | Lipids | pmid:8614307 |
Amet Y et al. | Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. | 1995 | Biochem. Pharmacol. | pmid:8615855 |
Saito M et al. | 2-(5-hydrazinocarbonyl-2-oxazolyl)-5,6-dimethoxybenzothiazole as a precolumn fluorescence derivatization reagent for carboxylic acids in high-performance liquid chromatography and its application to the assay of fatty acids in human serum. | 1995 | J. Chromatogr. B, Biomed. Appl. | pmid:8788145 |
Castle PJ et al. | Human liver lauric acid hydroxylase activities. | 1995 | Drug Metab. Dispos. | pmid:8654190 |
Valdes E et al. | Dietary fish oil and cytochrome P-450 monooxygenase activity in rat liver and kidney. | 1995 | Lipids | pmid:8538384 |
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Lee SK et al. | Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. | 1995 | Pancreas | pmid:7479681 |
Komata Y et al. | Accumulation of lauric acid in skin as an enhancer for the percutaneous absorption of thiamine disulfide. | 1995 | Biol. Pharm. Bull. | pmid:7493004 |
Modi S et al. | NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam. | 1995 | Biochemistry | pmid:7619797 |
Alterman MA et al. | Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575514 |
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Iwami Y et al. | Effect of sucrose monolaurate on acid production, levels of glycolytic intermediates, and enzyme activities of Streptococcus mutans NCTC 10449. | 1995 | J. Dent. Res. | pmid:7560425 |
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Ramarao MK et al. | Identification by in vitro mutagenesis of the interaction of two segments of C2MstC1, a chimera of cytochromes P450 2C2 and P450 2C1. | 1995 | J. Biol. Chem. | pmid:7829524 |
Hermansen JE | Prediction of milk fatty acid profile in dairy cows fed dietary fat differing in fatty acid composition. | 1995 | J. Dairy Sci. | pmid:7790578 |
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Godet MC et al. | Inclusion/exclusion of fatty acids in amylose complexes as a function of the fatty acid chain length. | 1995 | Int. J. Biol. Macromol. | pmid:8789347 |
Geissdörfer W et al. | Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1. | 1995 | Microbiology (Reading, Engl.) | pmid:7670642 |
Chaurasia CS et al. | Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. | 1995 | Arch. Biochem. Biophys. | pmid:7872779 |
Schwab US et al. | Lauric and palmitic acid-enriched diets have minimal impact on serum lipid and lipoprotein concentrations and glucose metabolism in healthy young women. | 1995 | J. Nutr. | pmid:7876922 |
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Preobrazhenskaia TA et al. | [Comparative effect of polymyxin B on lipid bilayer membranes with different lipid composition]. | 1994 Nov-Dec | Biofizika | pmid:7873621 |
Clarke SE et al. | Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. | 1994 Nov-Dec | Chem. Res. Toxicol. | pmid:7696540 |
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Mohan S and Raetz CR | Endotoxin biosynthesis in Pseudomonas aeruginosa: enzymatic incorporation of laurate before 3-deoxy-D-manno-octulosonate. | 1994 | J. Bacteriol. | pmid:7961456 |
Lee CK et al. | Relationship between lipophilicity and skin permeability of various drugs from an ethanol/water/lauric acid system. | 1994 | Biol. Pharm. Bull. | pmid:7874070 |
Komata Y et al. | Effect of fatty acid on the accumulation of thiamine disulfide in rat skin. | 1994 | Biol. Pharm. Bull. | pmid:7920438 |
Amet Y et al. | Evidence that cytochrome P450 2E1 is involved in the (omega-1)-hydroxylation of lauric acid in rat liver microsomes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8093035 |
Duncan T et al. | A glycoprotein binding retinoids and fatty acids is present in Drosophila. | 1994 | Arch. Biochem. Biophys. | pmid:8031123 |
Mirsky VM | Effect of the lipid hydrolysis products on the phospholipase A2 action towards lipid monolayer. | 1994 | Chem. Phys. Lipids | pmid:8013058 |
Grundy SM | Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977157 |
Nakamura M et al. | Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A. | 1994 | Biochem. Pharmacol. | pmid:7980643 |
Hornung B et al. | Lauric acid inhibits the maturation of vesicular stomatitis virus. | 1994 | J. Gen. Virol. | pmid:8113756 |
Hayes ML | Reduction in acid tolerance of Streptococcus downeii by fluoride and potassium laurate. | 1994 | Caries Res. | pmid:8156568 |
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Pinot F et al. | New cytochrome P450-dependent reactions from wheat: terminal and sub-terminal hydroxylation of oleic acid by microsomes from naphthalic acid anhydride and phenobarbital induced wheat seedlings. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8297392 |
Tholstrup T et al. | Fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison with fats high in palmitic acid or high in myristic and lauric acids. | 1994 | Am. J. Clin. Nutr. | pmid:8310987 |
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