MeSH term | MeSH ID | Detail |
---|---|---|
Atherosclerosis | D050197 | 85 associated lipids |
Vascular System Injuries | D057772 | 2 associated lipids |
Peripheral Arterial Disease | D058729 | 7 associated lipids |
lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Alves NF et al. | Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. | 2017 | Basic Clin. Pharmacol. Toxicol. | pmid:28054477 |
Stark K et al. | Expression of CYP4F12 in gastrointestinal and urogenital epithelia. | 2004 | Basic Clin. Pharmacol. Toxicol. | pmid:15078342 |
Russell VA et al. | Animal models of attention-deficit hyperactivity disorder. | 2005 | Behav Brain Funct | pmid:16022733 |
Bambal RB and Hanzlik RP | Active site structure and substrate specificity of cytochrome P450 4A1: steric control of ligand approach perpendicular to heme plane. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8605007 |
Imaoka S and Funae Y | Purification and NH2-terminal sequence of cytochrome P-450 from kidney microsomes of untreated male rats. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3801020 |
Leighton F et al. | Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732769 |
Okita R and Chance C | Induction of laurate omega-hydroxylase by di (2-ethylhexyl)phthalate in rat liver microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732809 |
Han S et al. | Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27890614 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Imai Y and Nakamura M | Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase). | 1989 | Biochem. Biophys. Res. Commun. | pmid:2493247 |