MeSH term | MeSH ID | Detail |
---|---|---|
Nephrosis, Lipoid | D009402 | 2 associated lipids |
Carotid Artery Injuries | D020212 | 8 associated lipids |
Vascular System Injuries | D057772 | 2 associated lipids |
lauric acid is a lipid of Fatty Acyls (FA) class. Lauric acid is associated with abnormalities such as Infection, Renal tubular disorder, Hypertensive disease, Obesity and Mycoses. The involved functions are known as Transcription, Genetic, Signal Transduction, Mutation, metaplastic cell transformation and Anabolism. Lauric acid often locates in Skin, Plasma membrane, Cytoplasmic matrix, Body tissue and Palmar surface. The associated genes with lauric acid are Gene Family, SLC33A1 gene, Homologous Gene, Open Reading Frames and P4HTM gene. The related lipids are Fatty Acids, Oleic Acids, Palmitates, Stearates and 9,11-linoleic acid.
To understand associated biological information of lauric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lauric acid is suspected in Renal tubular disorder, Hypertensive disease, Infection, Renal vascular disorder, Obesity, Mycoses and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with lauric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Christiansen A et al. | Effects of non-ionic surfactants on in vitro triglyceride digestion and their susceptibility to digestion by pancreatic enzymes. | 2010 | Eur J Pharm Sci | pmid:20633646 |
Pabla D et al. | Intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in MDCK epithelial cell line. | 2010 | Eur J Pharm Sci | pmid:20580671 |
El-Laithy HM | Novel transdermal delivery of Timolol maleate using sugar esters: preclinical and clinical studies. | 2009 | Eur J Pharm Biopharm | pmid:19126429 |
Santoyo S and Ygartua P | Effect of skin pretreatment with fatty acids on percutaneous absorption and skin retention of piroxicam after its topical application. | 2000 | Eur J Pharm Biopharm | pmid:10962234 |
Buszello K et al. | The influence of alkali fatty acids on the properties and the stability of parenteral O/W emulsions modified with solutol HS 15. | 2000 | Eur J Pharm Biopharm | pmid:10704897 |
Schwab M et al. | Studies on the lipase-induced degradation of lipid-based drug delivery systems. Part II - Investigations on the mechanisms leading to collapse of the lipid structure. | 2013 | Eur J Pharm Biopharm | pmid:23385286 |
Padula C et al. | Single-layer transdermal film containing lidocaine: modulation of drug release. | 2007 | Eur J Pharm Biopharm | pmid:17196804 |
Lippacher A et al. | Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties. | 2002 | Eur J Pharm Biopharm | pmid:11879997 |
Amet Y et al. | Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes. | 2000 | Eur J Nutr | pmid:11395987 |
Ishii Y et al. | Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells. | 2009 | Eur J Med Chem | pmid:19632009 |
Chevalier G et al. | Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract of Serenoa repens (Permixon) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-beta-sitosterol. | 1997 Jan-Mar | Eur J Drug Metab Pharmacokinet | pmid:9179563 |
Borges BC et al. | Update on nonsurgical, ultraconservative approaches to treat effectively non-cavitated caries lesions in permanent teeth. | 2011 | Eur J Dent | pmid:21494394 |
Temme EH et al. | Individual saturated fatty acids and effects on whole blood aggregation in vitro. | 1998 | Eur J Clin Nutr | pmid:9805214 |
Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
Idnurm A and Howlett BJ | Isocitrate lyase is essential for pathogenicity of the fungus Leptosphaeria maculans to canola (Brassica napus). | 2002 | Eukaryotic Cell | pmid:12455691 |
Mpharm KD et al. | Preparation and evaluation of transdermal plasters containing norfloxacin: a novel treatment for burn wound healing. | 2010 | Eplasty | pmid:20596234 |
Axarli I et al. | Cytochrome P450 102A2 Catalyzes Efficient Oxidation of Sodium Dodecyl Sulphate: A Molecular Tool for Remediation. | 2010 | Enzyme Res | pmid:21048857 |
de Souza RL et al. | Protic ionic liquid as additive on lipase immobilization using silica sol-gel. | 2013 | Enzyme Microb. Technol. | pmid:23410924 |
Grant C et al. | Whole-cell bio-oxidation of n-dodecane using the alkane hydroxylase system of P. putida GPo1 expressed in E. coli. | 2011 | Enzyme Microb. Technol. | pmid:22113020 |
Mustranta A et al. | Applications of immobilized lipases to transesterification and esterification reactions in nonaqueous systems. | 1993 | Enzyme Microb. Technol. | pmid:7763454 |
Takahashi K et al. | Modified lipoprotein lipase catalyzes ester synthesis in benzene. Substrate specificity. | 1984 | Enzyme | pmid:6526000 |
Brown JN and Smith TM | Inhibition of key glycolytic enzymes from rabbit kidney medulla by free fatty acids in vitro. | 1977 | Enzyme | pmid:142634 |
Katchamart S et al. | Effect of xenoestrogen exposure on the expression of cytochrome P450 isoforms in rainbow trout liver. | 2002 | Environ. Toxicol. Chem. | pmid:12389925 |
King SM et al. | Investigating primary marine aerosol properties: CCN activity of sea salt and mixed inorganic-organic particles. | 2012 | Environ. Sci. Technol. | pmid:22809370 |
Ayala-Luis KB et al. | Efficient dechlorination of carbon tetrachloride by hydrophobic green rust intercalated with dodecanoate anions. | 2012 | Environ. Sci. Technol. | pmid:22360442 |
Betts KS | Laureate extols genetic engineering's value for aiding hungry developing nations. | 2000 | Environ. Sci. Technol. | pmid:21657573 |
Kastner PE et al. | Specific accumulation of CYP94A1 transcripts after exposure to gaseous benzaldehyde: induction of lauric acid ω-hydroxylase activity in Vicia sativa exposed to atmospheric pollutants. | 2011 | Environ. Res. | pmid:21035797 |
Lake BG et al. | Hepatic effects of phthalate esters and related compounds--in vivo and in vitro correlations. | 1986 | Environ. Health Perspect. | pmid:3757955 |
Caldwell JC and Keshava N | Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis. | 2006 | Environ. Health Perspect. | pmid:16966105 |
Tilton SC et al. | Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. | 2008 | Environ. Health Perspect. | pmid:18709148 |
Elcombe CR and Mitchell AM | Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms. | 1986 | Environ. Health Perspect. | pmid:3104023 |
Ayoub SR et al. | Effects of several surfactants and high-molecular-weight organic compounds on decomposition of trichloroethylene with zerovalent iron powder. | 2008 | Environ Technol | pmid:18619141 |
Wang X et al. | Determination of thermodynamic and transport parameters of naphthenic acids and organic process chemicals in oil sand tailings pond water. | 2013 | Environ Sci Process Impacts | pmid:23736740 |
Külling DR et al. | Methane emissions of differently fed dairy cows and corresponding methane and nitrogen emissions from their manure during storage. | 2002 | Environ Monit Assess | pmid:12413300 |
Nishi Y et al. | Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. | 2005 | Endocrinology | pmid:15677766 |
Wan R et al. | Sex difference in urocortin production is contributory to the gender disparity in a rat model of vasculitis induced by sodium laurate. | 2013 | Endocrinology | pmid:24064363 |
Lear PV et al. | Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes. | 2010 | Endocrinology | pmid:20410201 |
Kopp A et al. | C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue. | 2010 | Endocrinology | pmid:20739398 |
The Endocrine Society 2009 Laureate Awards. | 2009 | Endocr. Rev. | pmid:19663077 | |
The Endocrine Society Laureate Awards. | 2009 | Endocr. Rev. | pmid:19663075 | |
The Endocrine Society 2012 Laureate Awards. | 2012 | Endocr. Rev. | pmid:23038815 | |
The Endocrine Society Laureate Awards. | 2012 | Endocr. Rev. | pmid:23038814 | |
The Endocrine Society 2007 Laureate Awards. | 2007 | Endocr. Rev. | pmid:17722366 | |
The Endocrine Society Laureate Awards. | 2007 | Endocr. Rev. | pmid:17722365 | |
The Endocrine Society 2011 Laureate Awards. | 2011 | Endocr. Rev. | pmid:21932463 | |
The Endocrine Society Laureate Awards. | 2011 | Endocr. Rev. | pmid:21932462 | |
Cao J et al. | Evaluation of the addition of various surfactant-suspended carbon nanotubes in MEEKC with an in situ-synthesized surfactant system. | 2011 | Electrophoresis | pmid:21254135 |
Petersson P et al. | Direct coupling of micellar electrokinetic chromatography to mass spectrometry using a volatile buffer system based on perfluorooctanoic acid and ammonia. | 2003 | Electrophoresis | pmid:12658688 |
Wikström M | [Nobel prize laureate in chemistry]. | 1978 | Duodecim | pmid:729494 |
Otomo S et al. | Prostaglandin E1 incorporated in lipid microspheres (lipo PGE1). | 1985 | Drugs Exp Clin Res | pmid:3880049 |
Goto J et al. | A comparison of the effect of Lipo PGE1 and other related compounds on experimental peripheral arterial occlusive disease in rats. | 1986 | Drugs Exp Clin Res | pmid:3816509 |
Miko M and DevÃnsky F | Biochemical basis of cytotoxic activity of some new N'-oxides of N',N'-dimethylaminoalkylamides of dodecanoic acid. | 1992 | Drug Metabol Drug Interact | pmid:1424644 |
Parkinson A et al. | On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice. | 2006 | Drug Metab. Rev. | pmid:16684660 |
Imai Y et al. | Structure-function relationships of cytochrome P-450 laurate (omega-1)-hydroxylase. | 1989 | Drug Metab. Rev. | pmid:2680391 |
Noble MA et al. | Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains. | 2007 | Drug Metab. Rev. | pmid:17786641 |
Yamaura Y et al. | Predicting oxidation sites with order of occurrence among multiple sites for CYP4A-mediated reactions. | 2011 | Drug Metab. Pharmacokinet. | pmid:21422671 |
Hayashi S et al. | Essential role of singlet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes. | 2005 | Drug Metab. Pharmacokinet. | pmid:15770071 |
Yasui H et al. | Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations. | 2002 | Drug Metab. Pharmacokinet. | pmid:15618693 |
Yamazaki H et al. | Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. | 2002 | Drug Metab. Pharmacokinet. | pmid:15618652 |
Minn AL et al. | Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa. | 2005 | Drug Metab. Dispos. | pmid:15879494 |
Pan J et al. | Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice. | 2003 | Drug Metab. Dispos. | pmid:12642464 |
Ozalp C et al. | Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells. | 2005 | Drug Metab. Dispos. | pmid:15980100 |
Graham RA et al. | In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs. | 2002 | Drug Metab. Dispos. | pmid:12386126 |
Castle PJ et al. | Human liver lauric acid hydroxylase activities. | 1995 | Drug Metab. Dispos. | pmid:8654190 |
Yang YH et al. | Heterologous expression of CYP2K1 and identification of the expressed protein (BV-CYP2K1) as lauric acid (omega-1)-hydroxylase and aflatoxin B1 exo-epoxidase. | 2000 | Drug Metab. Dispos. | pmid:11038153 |
Poloyac SM et al. | The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. | 2004 | Drug Metab. Dispos. | pmid:15205388 |
Buhler DR et al. | The regiospecific hydroxylation of lauric acid by rainbow trout (Oncorhynchus mykiss) cytochrome P450s. | 1997 | Drug Metab. Dispos. | pmid:9321521 |
Grillo MP and Lohr MT | Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes. | 2009 | Drug Metab. Dispos. | pmid:19196839 |
Grillo MP et al. | Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. | 2010 | Drug Metab. Dispos. | pmid:19786506 |
Li C et al. | Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. | 2003 | Drug Metab. Dispos. | pmid:12756204 |
Albro PW et al. | In vitro metabolism of mono-2-ethylhexyl phthalate by microsomal enzymes. Similarity to omega- and (omega-1) oxidation of fatty acids. | 1984 Nov-Dec | Drug Metab. Dispos. | pmid:6150824 |
Okita RT and Masters BS | Effect of phenobarbital treatment and cytochrome P-450 inhibitors on the laurate omega- and (omega - 1)-hydroxylase activities of rat liver microsomes. | 1980 May-Jun | Drug Metab. Dispos. | pmid:6104577 |
Dell HD et al. | Etofenamate fatty acid asters. An example of a new route of drug metabolism. | 1982 Jan-Feb | Drug Metab. Dispos. | pmid:6124384 |
Orton TC and Parker GL | The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid. | 1982 Mar-Apr | Drug Metab. Dispos. | pmid:6124394 |
Raza H and Levine WG | Azoreduction of N,N-dimethyl-4-aminoazobenzene (DAB) by rat hepatic microsomes. Selective induction by clofibrate. | 1986 Jan-Feb | Drug Metab. Dispos. | pmid:2868860 |
Levine WG and Raza H | Mechanism of azoreduction of dimethylaminoazobenzene by rat liver NADPH-cytochrome P-450 reductase and partially purified cytochrome P-450. Oxygen and carbon monoxide sensitivity and stimulation by FAD and FMN. | 1988 May-Jun | Drug Metab. Dispos. | pmid:2900738 |
Funke AP et al. | Development of matrix patches for transdermal delivery of a highly lipophilic antiestrogen. | 2003 | Drug Dev Ind Pharm | pmid:12906336 |
An NM et al. | Development of a novel soft hydrogel for the transdermal delivery of testosterone. | 2003 | Drug Dev Ind Pharm | pmid:12602497 |
Jung SY et al. | Formulation and evaluation of ubidecarenone transdermal delivery systems. | 2009 | Drug Dev Ind Pharm | pmid:19365779 |
Soler LI et al. | Transdermal delivery of alprazolam from a monolithic patch: formulation based on in vitro characterization. | 2012 | Drug Dev Ind Pharm | pmid:22204649 |
Hossain MA et al. | Effect of vehicle systems, pH and enhancers on the permeation of highly lipophilic aripiprazole from Carbopol 971P gel systems across human cadaver skin. | 2012 | Drug Dev Ind Pharm | pmid:22067044 |
Chisty MN et al. | In vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranes. | 2002 | Drug Dev Ind Pharm | pmid:12476868 |
Abu-Huwaij R et al. | Potential mucoadhesive dosage form of lidocaine hydrochloride: II. In vitro and in vivo evaluation. | 2007 | Drug Dev Ind Pharm | pmid:17523008 |
Pattnaik S et al. | Influence of chemical permeation enhancers on transdermal permeation of alfuzosin: an investigation using response surface modeling. | 2011 | Drug Dev Ind Pharm | pmid:21446831 |
Cho YA and Gwak HS | Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers. | 2004 | Drug Dev Ind Pharm | pmid:15285328 |
Hickey AJ and Byron PR | Effect of a non-hygroscopic surfactant coating upon fluorescein absorption from the respiratory tract. | 1987 | Drug Des. Deliv. | pmid:3509343 |
Mahdi ES et al. | Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. | 2011 | Drug Des Devel Ther | pmid:21792294 |
Joo HH et al. | In vitro permeation study of hinokitiol: effects of vehicles and enhancers. | 2008 | Drug Deliv | pmid:18197519 |
Kemper RA and Nabb DL | In vitro studies in microsomes from rat and human liver, kidney, and intestine suggest that perfluorooctanoic acid is not a substrate for microsomal UDP-glucuronosyltransferases. | 2005 | Drug Chem Toxicol | pmid:16051554 |
Hirata-Koizumi M et al. | Gender-related difference in the toxicity of 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole in rats: relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity. | 2009 | Drug Chem Toxicol | pmid:19538016 |
Mushtaq M et al. | Toxicological studies of a leachable stabilizer di-n-butyltin dilaurate(DBTL): effects on hepatic drug metabolizing enzyme activities. | 1981 | Drug Chem Toxicol | pmid:7261948 |
Pazo JA and Parafita MA | Synergism of ethanol and clofibrate in the lauric acid hydroxylation. | 1988 | Drug Alcohol Depend | pmid:3416732 |
Bogdanova LR et al. | Micellar catalytic effect as a factor of lipase activity regulation. | 2012 Sep-Oct | Dokl. Biochem. Biophys. | pmid:23132718 |
Fernandes R et al. | Relationship between acute phase proteins and serum fatty acid composition in morbidly obese patients. | 2013 | Dis. Markers | pmid:24167354 |
Vessey DA | Isolation and preliminary characterization of the medium-chain fatty acid:CoA ligase responsible for activation of short- and medium-chain fatty acids in colonic mucosa from swine. | 2001 | Dig. Dis. Sci. | pmid:11281196 |
Ma J et al. | A randomised trial of enteric-coated nutrient pellets to stimulate gastrointestinal peptide release and lower glycaemia in type 2 diabetes. | 2013 | Diabetologia | pmid:23471488 |
Iaconelli A et al. | Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes. | 2010 | Diabetes Care | pmid:20724647 |
Tan CP et al. | Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. | 2008 | Diabetes | pmid:18477808 |
Yeop Han C et al. | Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. | 2010 | Diabetes | pmid:19934003 |
Tabatabai LB and Deyoe BL | Biochemical and biological properties of soluble protein preparations from Brucella abortus. | 1984 | Dev. Biol. Stand. | pmid:6436094 |